Testing Status of Acrylonitrile 11128-X
CASRN: 107-13-1
Formula: C3-H3-N
Synonyms/Common Names
- AN
- 2-Propenenitrile
Short-Term Toxicity
- 13 weeks (Gavage)
(C50215B)
Completed
- Mice: B6C3F1
- Dose: MICE: 0, 5, 10, 20, 40, OR 60 MG/KG; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C50215B)
Completed
- TR-506 (NIH Number: 02-4440)
(Peer Review Approval 05/03/2001A )
Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE.
- TR-506 (NIH Number: 02-4440)
(Peer Review Approval 05/03/2001A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage)
(S0712)
Completed
- Citation: Burka LT, Sanchez IM, Ahmed AE, Ghanayem BI. Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch Toxicol. 1994;68(10):611-8.Pubmed Abstract
- Male Rats: F344/N
- Other (Gavage)
(S0711)
Completed
- Citation: Farooqui MY, Mumtaz MM, Ghanayem BI, Ahmed AE. Hemoglobin degradation, lipid peroxidation, and inhibition of Na /K( )-ATPase in rat erythrocytes exposed to acrylonitrile. J Biochem Toxicol. 1990 Winter;5(4):221-7.Pubmed Abstract
- Male Rats: Sprague Dawley
Genetic Toxicology
- Drosophila
(701238)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
- Sex-Linked Recessive Lethal Negative
- Reciprocal Translocation Negative
- In Vitro Cytogenetics (CA/SCE)
(269328)
Completed
- Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A56933)
Completed
- Mice: B6C3F1
- Female Negative
- Micronucleus
(A69991)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(A92525)
Completed
- Mice: B6C3F1
- Female Negative
- Mouse Lymphoma
(189387)
Completed
- Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
- Mice
- Positive
- Salmonella
(198018)
Completed
- Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
- Positive