Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Pentachlorophenol, purified 11616-H


CASRN: 87-86-5

Formula: C6-H-Cl5-O

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C54933)  Completed 
    • Mice: B6C3F1
  • 4 weeks (Dosed-Feed)  (C89002)  Completed 
    • Rats: F344/N
    • Dose: R: 0, 200, 400, 800, 1600, OR 3200 PPM; 10/SEX/GROUP.
  • 26 weeks (Dosed-Feed)  (C54933)  Completed 
    • Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C89002)  Completed 
    • TR-483 (NIH Number: 99-3973)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Pentachlorophenol in F344/N Rats (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
    • Dose: R: 0, 200, 400, OR 600 PPM; 50/SEX/GROUP - 1000 PPM STOP STUDY (60/SEX).

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0328)  Completed 
    • Citation: Yuan JH, Goehl TJ, Murrill E, Moore R, Clark J, Hong HL, Irwin RD. Toxicokinetics of pentachlorophenol in the F344 rat. Gavage and dosed feed studies. Xenobiotica. 1994 Jun;24(6):553-60.Pubmed Abstract
    • Male and Female Rats: F344/N
    • Dose: 18.75, 75, & 150 mg/kg bwt. 5 mg/kg bwt.
  • Toxicokinetic Study (Dosed-Feed)  (S0579)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 200, 400 or 600 ppm (1000 ppm stop study).