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Testing Status of 4-Methylcyclohexanemethanol (MCHM) 14001

 

CASRN: 34885-03-5

Formula: C8-H16-O

Synonyms/Common Names

  • Cyclohexanemethanol, 4-methyl-
  • MCHM

Short-Term Toxicity

  • 5 days (Gavage)  (C14001)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: Male: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 8 rats in 0 mg/kg group, 6 rats in each treated group.

Special Studies

  • C. elegans  (W14001)  Completed 
    • C. elegans: N2
    • Dose: Feeding: 0, 200, 100, 75 uM; Repro: 0, 200, 100, 75, 50 uM.
  • 5 days Zebrafish  (Z14001)  Completed 
    • Exposure: 0, 0.3, 2.3. 4.5, 6.5, 8.5, 10.8, 12.8 ppm.
    • Zebrafish: Danio rerio

Genetic Toxicology

  • Micronucleus  (G14001)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
  • Salmonella  (G14001B)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 7 days Immunotoxicity (Topical Application)  (I14001)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP immunotoxicity technical report on the dermal hypersensitivity and irritancy studies of 4-methylcyclohexanemethanol (CASRN 34885-03-5) and crude 4-methylcyclohexanemethanol administered topically to female BALB/c mice. Research Triangle Park, NC: National Toxicology Program. Immunotoxicity Report 01.
    • Female Mice: BALB/c
    • Dose: 0, 2, 20 or 100/50%.
  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R14001B)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of 4 methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 02. https://doi.org/10.22427/NTP-DART-02
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 50, 100, 200, or 400 mg/kg.
  • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R14001)  Completed 
    •   (Peer Review Approval 10/18/2019A ) Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of 4 methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 02. https://doi.org/10.22427/NTP-DART-02
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 150, 300, 600, or 900 mg/kg.

Toxicogenomics

  • Microarray Analysis (Gavage)  (T14001)  Completed 
    • Short Term Toxicogenomic Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 6 rats/dose group.