Testing Status of Decalin 91178

CASRN: 91-17-8

Related: TETRALIN (CAS: 119-64-2)

Formula: C10-H18

Synonyms/Common Names

• Naphthalene, decahydro-

Short-Term Toxicity

• 2 weeks (Inhalation)  (C93026)  Completed 
  • Rats: F344/N; Rats: NCI Black Reiter (NBR); Mice: B6C3F1
  • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM; 5/SEX/SPECIES/GROUP.
• 13 weeks (Inhalation)  (C93026)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM R: 20/SEX/GROUP M: 10/SEX/GROUP MR: 5/GROUP RENAL TOX.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C93026)  Completed 
  • TR-513 (NIH Number: 05-4447)  (Peer Review Approval 09/05/2002A )
    Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Clear Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice Equivocal Evidence 
  • Dose: M&F MICE AND FEMALE RATS: 0, 25, 100, OR 400 PPM MALE RATS: 0, 25, 50, 100, OR 400 PPM (20 MALES); 50/SEX/SPECIES/GROUP.

Special Studies

• Toxicokinetic Study (Inhalation)  (K93026)   
  • Rats: Fischer 344; Mice: B6C3F1

Genetic Toxicology

• Micronucleus  (A40482)  Completed 
  • Mice: B6C3F1
  • Male Weakly Positive 
  • Female Negative 
• Salmonella  (A08124)  Completed 
  •  Negative 

Organ Systems Toxicity

• 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0037)  Completed 
  • Citation: Screening of Priority Chemicals for Reproductive Hazards
  • Female Mice: Swiss
  • Dose: 2700 MG/KG BODY WEIGHT.