Testing Status of alpha-Methylstyrene 98839

CASRN: 98-83-9

Formula: C9-H10

Synonyms/Common Names

• Benzene, (1-methylethenyl)- (9CI)
• Isopropenylbenzene

Short-Term Toxicity

• 2 weeks (Inhalation)  (C88006)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13 weeks (Inhalation)  (C88006B)  Completed 
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R&M: 0, 75, 150, 300, 600 OR 1000 PPM; R: 20/SEX M: 10/SEX.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C88006B)  Completed 
  • TR-543 (NIH Number: 08-4474)  (Peer Review Approval 06/12/2006A )
    Toxicology and Carcinogenesis Studies of alpha-Methylstyrene (CASRN 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1/N
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats No Evidence 
    • Male Mice Equivocal Evidence 
    • Female Mice Clear Evidence 
  • Dose: R: 0, 100, 300, OR 1000 PPM M: 0, 100, 300, OR 600 PPM; 50/SEX/SPECIES.

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Inhalation)  (S0632)  Completed 
  • Male Rats: F344/N
  • Dose: iv: 10 mg/kg gavage: 1000 mg/kg inhalation: 300 and 900 ppm.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (235924)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Negative 
• Micronucleus  (A36497)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Positive 
• Salmonella  (338665)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative