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Testing Status of alpha-Methylstyrene 98839

 

CASRN: 98-83-9

Formula: C9-H10

Synonyms/Common Names

  • Benzene, (1-methylethenyl)- (9CI)
  • Isopropenylbenzene

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C88006)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Inhalation)  (C88006B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 75, 150, 300, 600 OR 1000 PPM; R: 20/SEX M: 10/SEX.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C88006B)  Completed 
    • TR-543 (NIH Number: 08-4474)  (Peer Review Approval 06/12/2006A )
      Toxicology and Carcinogenesis Studies of α-Methylstyrene (CASRN 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 100, 300, OR 1000 PPM M: 0, 100, 300, OR 600 PPM; 50/SEX/SPECIES.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Inhalation)  (S0632)  Completed 
    • Male Rats: F344/N
    • Dose: iv: 10 mg/kg gavage: 1000 mg/kg inhalation: 300 and 900 ppm.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (235924)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A36497)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (338665)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative