Testing Status of alpha-Methylstyrene 98839
CASRN: 98-83-9
Formula: C9-H10
Synonyms/Common Names
- Benzene, (1-methylethenyl)- (9CI)
- Isopropenylbenzene
Short-Term Toxicity
- 2 weeks (Inhalation)
(C88006)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13 weeks (Inhalation)
(C88006B)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 75, 150, 300, 600 OR 1000 PPM; R: 20/SEX M: 10/SEX.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C88006B)
Completed
- TR-543 (NIH Number: 08-4474)
(Peer Review Approval 06/12/2006A )
Toxicology and Carcinogenesis Studies of alpha-Methylstyrene (CASRN 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Equivocal Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 100, 300, OR 1000 PPM M: 0, 100, 300, OR 600 PPM; 50/SEX/SPECIES.
- TR-543 (NIH Number: 08-4474)
(Peer Review Approval 06/12/2006A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Inhalation)
(S0632)
Completed
- Male Rats: F344/N
- Dose: iv: 10 mg/kg gavage: 1000 mg/kg inhalation: 300 and 900 ppm.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(235924)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(A36497)
Completed
- Mice: B6C3F1
- Male Negative
- Female Positive
- Salmonella
(338665)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative