Testing Status of Sodium nitrite C02084

CASRN: 7632-00-0

Formula: H-N-O2.Na

Synonyms/Common Names

• Diazotizing salts
• Nitrous acid, sodium salt

Short-Term Toxicity

• 13 weeks (Dosed-Water)  (C88007)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 375 - 5000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Dosed-Water)  (C88007B)  Completed 
  • TR-495 (NIH Number: 01-3954)  (Peer Review Approval 05/18/2000A )
    Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice Equivocal Evidence 
  • Dose: R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE.

Special Studies

• Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0548)  Completed 
  • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Dose: 20 mg/kg [R,M]. 40 or 80 mg/kg. 62.5 or 125 mg/kg.

Genetic Toxicology

• Micronucleus  (A10342)  Completed 
  • Rats: Fischer 344
  • Male Negative 
• Micronucleus  (A17282)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A52858)  Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (359703)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Positive 

Organ Systems Toxicity

• Continuous Breeding (Legacy) (Dosed-Water)  (RACB88071)  Completed 
  • Male and Female Mice: Swiss
  • Dose: 0, .06, .12, .24, .36, .48%; 0, .06, .12, .24%; N/A; 0, .24%.