Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1,1-Dichloroethane C04535

 

CASRN: 75-34-3

Formula: C2-H4-Cl2

Synonyms/Common Names

  • Ethylidene dichloride

Short-Term Toxicity

  • 14-Day (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 562, 5620, M: 0, 1000, 10000 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04535)  Completed 
    • TR-066 (NIH Number: 78-1316)  (Peer Review Approval 01/18/1978A )
      Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CASRN 75-34-3)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: MR: 0, 382, 764 (AVG), FR: 0, 475, 950 (AVG), MM: 0, 1442, 2885 (AVG), FM: 0, 1665, 3331 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (508873)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (777132)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative