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Testing Status of alpha-Pinene M030014

 

CASRN: 80-56-8

Formula: C10-H16

Synonyms/Common Names

  • Acintene A
  • Cyclic Dexadiene
  • 2-Pinene
  • 2,6,6-Trimethylbicyclo(3.1.1)-2-hept-2-ene

Secondary:

  • MONOTERPENES - Occupational Exposure Assessment of alpha-Pinene and related Monoterpenes

Short-Term Toxicity

  • 14 days (Inhalation)  (C20302)  Completed 
    • TOX-81 (NIH Number: 16-5937)
      Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 100, 200, 400, 800, or 1600 ppm; 5/sex/species/dose.
  • 7 days (Inhalation)  (C20302B)  Data in Review 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 50 or 100 ppm, M: 0, 50 or 100 ppm.
  • 13 weeks (Inhalation)  (C20302)  Completed 
    • TOX-81 (NIH Number: 16-5937)
      Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 ppm; R: 20/sex/dose; M: 10/sex/dose.
  • 90 days (Inhalation)  (C20302B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 50, 100, 200 ppm.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20302B)  On Test 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 50, 100, or 200 ppm 50/sex/exposure concentration; Mice: 0, 100, 200, or 400 ppm 50/sex exposure concentration.

Special Studies

  • 7 days Toxicokinetic Study (Inhalation)  (K03014)  Completed 
    • 7-day inhalation
    • Citation: Waidyanatha S, Hackett M, Black SR, Stout MD, Fennell TR, Silinski MR, Watson SL, Licause J, Robinson VG, Sparrow B, Fernando RA, Cooper S, Rider CV. Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents. Toxicol Appl Pharmacol. 2021 May 1;418:115496. doi: https://doi.org/10.1016/j.taap.2021.115496. Epub 2021 Mar 18.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 50 and 100 ppm.
  • 7 days Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous) Selected (K03014B)  
    • Male and Female Rats: Hsd:Sprague Dawley SD; Male and Female Mice: B6C3F1/N
    • Dose: gavage 1.5, 15, 150 mg/kg; intravenous 1.5 mg/kg.

Genetic Toxicology

  • Micronucleus  (A82162)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A29697)  Completed 
    •  Negative 
  • 48 hours Salmonella (in-vitro)  (G03014)  Completed