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Testing Status of Benzyltrimethyl ammonium chloride M200008

 

CASRN: 56-93-9

Formula: C10-H16-N.Cl

Synonyms/Common Names

  • Benzenemethanaminium, N,N,N-trimethyl-, chloride (9CI)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88139)  Completed 
    • TOX-57 (NIH Number: 00-4405)
      Toxicity Studies of Benzyltrimethylammonium Chloride Administered to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 15.7, 31.3, 62.5, 125, OR 250 MG/KG/DAY; M: 0, 62.5, 125, 250, 500, OR 1000 MG/KG/DAY; 5/GRP/SEX (MALE & FEMALE).
  • 2 weeks (Topical Application)  (C88139B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: M&F; RATS: 0, 11.9, 39.6, 118.8 MG/ANIMAL/DAY; MICE: 0, 4.0, 13.2, 39.6 MG/ANIMAL/DAY; 5/GRP/SEX.
  • 13 weeks (Gavage)  (C88139C)  Completed 
    • TOX-57 (NIH Number: 00-4405)  (Tox Peer Review 10/00/1998A )
      Toxicity Studies of Benzyltrimethylammonium Chloride Administered to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 12.5, 25, 50, OR 100 MG/KG 10/SEX/SPECIES/GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Gavage)  (S0314)  Completed 
    • Citation: Sanders JM, Griffin RJ, Burka LT, Matthews HB. Toxicokinetics of the cholinomimetic compound benzyltrimethylammonium chloride in the male rat and mouse. Xenobiotica. 1995 Mar;25(3):303-13Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 0.63, 6.3, 63.0 mg/kg. 0.63, 6.3, 63.0 mg/kg [R,M].
  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0532)  Completed 
    • Citation: Sanders JM, Griffin RJ, Burka LT, Matthews HB. Toxicokinetics of the cholinomimetic compound benzyltrimethylammonium chloride in the male rat and mouse. Xenobiotica. 1995 Mar;25(3):303-13Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.63, 6.3 mg/kg.

Genetic Toxicology

  • Micronucleus  (A31673)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Salmonella  (431373)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative