Testing Status of Benzyltrimethyl ammonium chloride M200008
CASRN: 56-93-9
Formula: C10-H16-N.Cl
Synonyms/Common Names
- Benzenemethanaminium, N,N,N-trimethyl-, chloride (9CI)
Short-Term Toxicity
- 2 weeks (Gavage)
(C88139)
Completed
- TOX-57 (NIH Number: 00-4405)
Toxicity Studies of Benzyltrimethylammonium Chloride Administered to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 15.7, 31.3, 62.5, 125, OR 250 MG/KG/DAY; M: 0, 62.5, 125, 250, 500, OR 1000 MG/KG/DAY; 5/GRP/SEX (MALE & FEMALE).
- TOX-57 (NIH Number: 00-4405)
- 2 weeks (Topical Application)
(C88139B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: M&F; RATS: 0, 11.9, 39.6, 118.8 MG/ANIMAL/DAY; MICE: 0, 4.0, 13.2, 39.6 MG/ANIMAL/DAY; 5/GRP/SEX.
- 13 weeks (Gavage)
(C88139C)
Completed
- TOX-57 (NIH Number: 00-4405)
(Tox Peer Review 10/00/1998A )
Toxicity Studies of Benzyltrimethylammonium Chloride Administered to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 12.5, 25, 50, OR 100 MG/KG 10/SEX/SPECIES/GROUP.
- TOX-57 (NIH Number: 00-4405)
(Tox Peer Review 10/00/1998A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Gavage)
(S0314)
Completed
- Citation: Sanders JM, Griffin RJ, Burka LT, Matthews HB. Toxicokinetics of the cholinomimetic compound benzyltrimethylammonium chloride in the male rat and mouse. Xenobiotica. 1995 Mar;25(3):303-13Pubmed Abstract
- Male Rats: F344/N; Male Mice: B6C3F1
- Dose: 0.63, 6.3, 63.0 mg/kg. 0.63, 6.3, 63.0 mg/kg [R,M].
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous)
(S0532)
Completed
- Citation: Sanders JM, Griffin RJ, Burka LT, Matthews HB. Toxicokinetics of the cholinomimetic compound benzyltrimethylammonium chloride in the male rat and mouse. Xenobiotica. 1995 Mar;25(3):303-13Pubmed Abstract
- Male Rats: F344/N
- Dose: 0.63, 6.3 mg/kg.
Genetic Toxicology
- Micronucleus
(A31673)
Completed
- Mice: B6C3F1
- Male Positive
- Female Positive
- Salmonella
(431373)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative