Testing Status of Isoprene M200028

2 weeks (Inhalation) (C61825) Completed
- TOX-31 (NIH Number: 95-3354)
  Toxicity Studies of Isoprene Administered by Inhalation to F344/N Rats and B6C3F1 Mice
- Rats: F344/N; Mice: B6C3F1
13 weeks (Inhalation) (C61825) Completed
- TOX-31 (NIH Number: 95-3354) (Tox Peer Review 11/17/1993A )
  Toxicity Studies of Isoprene Administered by Inhalation to F344/N Rats and B6C3F1 Mice
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 70, 220, 700, 2200, 7000 PPM.
26 weeks (Inhalation) (C61825C) Completed
- TOX-31 (NIH Number: 95-3354) (Tox Peer Review 11/17/1993A )
  Toxicity Studies of Isoprene Administered by Inhalation to F344/N Rats and B6C3F1 Mice
- Rats: F344/N; Mice: B6C3F1
- Dose: MALES ONLY; R&M: 0, 70, 220, 700, 2200, 7000 PPM.

Absorption Disposition Metabolism Elimination (Inhalation) (S0227) Completed
- Citation: Bond JA, Bechtold WE, Birnbaum LS, Dahl AR, Medinsky MA, Sun JD, Henderson RF. Disposition of inhaled isoprene in B6C3F1 mice. Toxicol Appl Pharmacol. 1991 Mar 1;107(3):494-503. Pubmed Abstract
- Citation: Dahl AR, Birnbaum LS, Bond JA, Gervasi PG, Henderson RF. The fate of isoprene inhaled by rats: comparison to butadiene. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):237-48.Pubmed Abstract
- Male Rats: F344/N
Absorption Disposition Metabolism Elimination (Intraperitoneal Injection) (S0460) Completed
- Citation: Sun JD, Dahl AR, Bond JA, Birnbaum LS, Henderson RF. Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene. Toxicol Appl Pharmacol. 1989 Aug;100(1):86-95.Pubmed Abstract
- Male Rats: Sprague Dawley; Male Mice: B6C3F1
- Dose: 0.3, 3.0, 300, 1000 OR 3000 UMOL [14C]ISOPRENE.
Metabolism (Intraperitoneal Injection) (S0338) Completed
- Male Rats: F344/N; Male Mice: B6C3F1
- Dose: PILOT 1: 33.2 MG/KG MOUSE; 66.6 MG/KG RAT; PILOT 2: 66.2 MG/KG RAT; STUDY A: 66.4 MG/KG RAT; STUDY CM: 68.4 MG/KG MOUSE..
Modeling (S0648) Completed

Chromosome Aberrations (A63977) Completed
- Mice
- Negative (Nonstandard Protocol)
In Vitro Cytogenetics (CA/SCE) (032841) Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
Micronucleus (A28566) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Positive
Micronucleus (A63977) Completed
- Mice: B6C3F1
- Male Positive
Salmonella (453451) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Sister Chromatid Exchanges (A63977) Completed
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)
Sister Chromatid Exchanges (C78795) Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., Paquette, D.F., Melnick, R.L., and Shelby, M.D. Chloroprene and isoprene: Cytogenetic studies in mice. Mutagenesis. Vol. 3 (1988) 141-146
- Mice
- Sister Chromatid Positive

6 to 17 GD for mice Conventional Teratology (Inhalation) (TER88045) Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 280, 1400, 7000 ppm.
6 to 19 GD Conventional Teratology (Inhalation) (TER88142) Completed
- Rats: Sprague Dawley
- Rats Maternal Negative
- Rats Fetal Negative
- Dose: 0, 280, 1400, 7000 ppm.