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Testing Status of Cyclohexanone oxime M88037

 

CASRN: 100-64-1

Formula: C6-H11-N-O

Synonyms/Common Names

  • (Hydroxyimino)cyclohexane

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C88047)  Completed 
    • TOX-50 (NIH Number: 96-3934)  (Peer Review Approval 05/00/1995A )
      Toxicity Studies of Cyclohexanone Oxime Administered by Drinking Water to B6C3F1 Mice
    • Mice: B6C3F1
    • Dose: M: 0, 106, 312, 625, 1250, OR 2500 PPM; 5/GROUP.
  • 13 weeks (Dosed-Water)  (C88047)  Completed 
    • TOX-50 (NIH Number: 96-3934)  (Tox Peer Review 03/00/1995A )
      Toxicity Studies of Cyclohexanone Oxime Administered by Drinking Water to B6C3F1 Mice
    • Mice: B6C3F1
    • Dose: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 10/GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application)  (S0707)  Completed 
    • Citation: Parmar D, Burka LT. Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Drug Metab Dispos. 1991 Nov-Dec;19(6):1101-7.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 1, 10, and 30 mg/kg in 5 ml/kg of dosing solution. 30 mg/kg and applied at 0.2 ml/kg to the interscapular area.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A35717)  Completed 
    • Sister Chromatid Exchange Not Tested 
    • Chromosome Aberrations Equivocal 
  • Micronucleus  (A45594)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A87965)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (152023)  Completed 
    •  Positive