Testing Status of 2',3'-Dideoxycytidine M88290
CASRN: 7481-89-2
Formula: C9-H13-N3-O3
Synonyms/Common Names
- Cytidine, 2',3'-dideoxy-
- DDC (AIDS Initiative)
- 2',3'-Dideoxycytidine (AIDS Initiative)
Short-Term Toxicity
- 4 weeks (Gavage)
(C88073C)
Completed
- Mice: NIH Swiss
- 13 weeks (Gavage)
(C88073)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: (GIVEN AS DIVIDED DOSE AT 9AM AND 3PM) 0, 125, 250, 500, 1000, OR 2000 MG/KG.
- 13 & 26 weeks (Gavage)
(C88073B)
Completed
- Mice: B6C3F1
- Dose: FEMALE MICE ONLY: 500 0R 1000 MG/KG/DAY.
- 26 weeks (Gavage)
(C88073C)
Completed
- Mice: B6C3F1; Mice: NIH Swiss
Special Studies
- 1 day Toxicokinetic Study (Gavage)
(K88073-1)
Completed
- Mice: B6C3F1
- Dose: 84, 169, 375, 750, 1500 mg/kg. Single dose and two doses of 750 mg/kg.
- 1 day Toxicokinetic Study (Gavage)
(K88073-2)
Completed
- Rats: Fischer 344
- Dose: 84, 169, 375, 652, 1154 mg/kg. Single dose and two doses of 652 mg/kg.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(955544)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(029073)
Completed
- Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
- Mice: B6C3F1
- Male Positive
- Salmonella
(258838)
Completed
- Weakly Positive
Organ Systems Toxicity
- Continuous Breeding (Legacy) (Dosed-Feed)
(RACB92125)
Completed
- Male and Female Monkeys: Rhesus
- Dose: N/A; 0, .06, .6 MG/KG; N/A; N/A.
- 6 to 15 GD Conventional Teratology (Gavage)
(TER87145)
Completed
- Mice: C57BL/6
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 200, 400, 1000, 2000 MG/KG/DAY.
- 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)
(RACB92122)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, 200, 400, 1000 MG/KG; N/A; N/A.