Testing Status of 2',3'-Dideoxycytidine M88290

CASRN: 7481-89-2

Formula: C9-H13-N3-O3

Synonyms/Common Names

• Cytidine, 2',3'-dideoxy-
• DDC (AIDS Initiative)
• 2',3'-Dideoxycytidine (AIDS Initiative)

Short-Term Toxicity

• 4 weeks (Gavage)  (C88073C)  Completed 
  • Mice: NIH Swiss
• 13 & 26 weeks (Gavage)  (C88073B)  Completed 
  • Mice: B6C3F1
  • Dose: FEMALE MICE ONLY: 500 0R 1000 MG/KG/DAY.
• 26 weeks (Gavage)  (C88073C)  Completed 
  • Mice: B6C3F1; Mice: NIH Swiss
• 13 weeks (Gavage)  (C88073)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: (GIVEN AS DIVIDED DOSE AT 9AM AND 3PM) 0, 125, 250, 500, 1000, OR 2000 MG/KG.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (955544)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (029073)  Completed 
  • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (258838)  Completed 
  •  Weakly Positive 

Organ Systems Toxicity

• Continuous Breeding (Legacy) (Dosed-Feed)  (RACB92125)  Completed 
  • Male and Female Monkey: Rhesus
  • Dose: N/A; 0, .06, .6 MG/KG; N/A; N/A.
• 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB92122)  Completed 
  • Male and Female Mice: Swiss
  • Dose: N/A; 0, 200, 400, 1000 MG/KG; N/A; N/A.
• 6 to 15 GD Conventional Teratology (Gavage)  (TER87145)  Completed 
  • Mice: C57BL/6
  • Mice Maternal Positive 
  • Mice Fetal Positive 
  • Dose: 0, 200, 400, 1000, 2000 MG/KG/DAY.