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Testing Status of Gemfibrozil M930066

 

CASRN: 25812-30-0

Formula: C15-H22-O3

Synonyms/Common Names

  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoic acid

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous; Gavage; Intravenous)  (S0541)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: PRELM MICE IV: 16.6 MG/KG PO: 16.6, 2124.8 MG/KG FEED: 200, 16000 PPM; PRELM RAT IV: 4.29 MG/KG PO: 4.29, 685.7 MG/KG FEED: 100, 16000 PPM; PRELM HAMSTER IV: 15 MG/KG PO: 30, 1000 MG/KG FEED: 1500, 12000 PPM (2.1 & 107.1 MG/KG). SA MICE IV: 8.4 MG/KG PO: 8.4, 16.6, 49.8 MG/KG; SA RAT IV: 4.29 PO: 4.29, 50, 100 MG/KG; SA HAMSTER IV: 15 MG/KG PO: 8, 15, 30 MG/KG..
  • Toxicokinetic Study (Dosed-Feed)  (S0582)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 14D: HAMSTERS 1500, 3000, 6000, 12000 OR 24000; 90D: RATS 10, 100, 1000, 8000 OR 16000 PPM; MICE 10, 100, 1000, 4000 OR 8000 PPM; HAMSTERS 100, 1000, 6000, 12000, 24000 ppm.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0637)  Completed 
    • Citation: Dix KJ, Coleman DP, Jeffcoat AR. Comparative metabolism and disposition of gemfibrozil in male and female Sprague-Dawley rats and Syrian golden hamsters. Drug Metab Dispos. 1999 Jan;27(1):138-46.Pubmed Abstract
    • Citation: Thomas BF, Burgess JP, Coleman DP, Scheffler NM, Jeffcoat AR, Dix KJ. Isolation and identification of novel metabolites of gemfibrozil in rat urine. Drug Metab Dispos. 1999 Jan;27(1):147-57.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden