Testing Status of 5-(Hydroxymethyl)-2-furfural M950006

CASRN: 67-47-0

Formula: C6-H6-O3

Synonyms/Common Names

• HMF
• 5-(Hydroxymethyl)-2-furancarboxaldehyde (9CI)
• 5(Hydroxymethyl)furfural

Short-Term Toxicity

• 2 weeks (Gavage)  (C95011)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 94, 188, 375, 750, OR 1500 MG/KG.
• 13 weeks (Gavage)  (C95011)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 94, 188, 375, 750 OR 1500 MG/KG; M: 0, 47, 94, 188, 375, OR 750 MG/KG.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C95011B)  Completed 
  • TR-554 (NIH Number: 10-5895)  (Peer Review Approval 02/27/2008A )
    Toxicology and Carcinogenesis Studies of 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1/N
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice Some Evidence 
  • Dose: R&M: 0, 188, 375, OR 750 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage)  (S0620)  Completed 
  • Citation: Godfrey VB, Chen LJ, Griffin RJ, Lebetkin EH, Burka LT. Distribution and metabolism of (5-hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration. J Toxicol Environ Health A. 1999 Jun 11;57(3):199-210.Pubmed Abstract
  • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Dose: 5, 100, 500 mg/kg [R,M].

Genetic Toxicology

• Micronucleus  (A40470)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A22124)  Completed 
  •  Weakly Positive 
• Salmonella  (A43477)  Completed 
  •  Negative