Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Endocrine disruptor (Genistein) M960022

 

CASRN: 446-72-0

Formula: C15-H10-O5

Synonyms/Common Names

  • Genistein (Endocrine disruptor)
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C99040)  Completed 
    • TR-545 (NIH Number: 08-4430)  (Peer Review Approval 06/12/2006A )
      Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study)
    • Rats: Sprague Dawley
    • Carcinogenesis Results
      • In Utero and continuing for 2 years:
        • Male Rats = No Evidence
        • Female Rats = Some Evidence
      • In Utero and continuing for 20 weeks:
        • Male Rats = No Evidence
        • Female Rats = Equivocal Evidence
      • In Utero and continuing for Post Natal Day 21:
        • Male Rats = No Evidence
        • Female Rats = Equivocal Evidence
    • Dose: 0, 5, 100, or 500 ppm.

Organ Systems Toxicity

  • Multigenerational Screen (Dosed-Feed)  (MG96005)  Completed 
    • NIH Number: 08-4477
      Citation: Multigenerational Reproductive Toxicology Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study)
    • Male and Female Rats: Sprague Dawley
    • Reproductive Dose Range Finding (On Test)
      • Days of Treatment: 28 DAYS
      • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
    • Immunotoxicity (On Test)
      • Days of Treatment: 4 WEEKS
      • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
    • Behavioral Toxicity (On Test)
      • Days of Treatment: 10 WEEKS
      • Dose: 0, 25, 250, OR 1250 PPM
    • Multigeneration Reproductive Study (F0) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F1) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F2) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F3) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Multigeneration Reproductive Study (F4) (On Test)
      • Days of Treatment: 20 WEEKS
      • Dose: 0, 5, 100, OR 500 PPM
    • Cancer Study (F1) (On Test)
      • Days of Treatment: 2 YEARS
      • Dose: 0, 5, 100, OR 500 PPM
    • Cancer Study (F3) (On Test)
      • Days of Treatment: 2 YEARS
      • Dose: 0, 5, 100, OR 500 PPM