Testing Status of Endocrine disruptor (Genistein) M960022
CASRN: 446-72-0
Formula: C15-H10-O5
Synonyms/Common Names
- Genistein (Endocrine disruptor)
- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C99040)
Completed
- TR-545 (NIH Number: 08-4430)
(Peer Review Approval 06/12/2006A )
Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study) - Rats: Sprague Dawley
- Carcinogenesis Results
- In Utero and continuing for 2 years:
- Male Rats = No Evidence
- Female Rats = Some Evidence
- In Utero and continuing for 20 weeks:
- Male Rats = No Evidence
- Female Rats = Equivocal Evidence
- In Utero and continuing for Post Natal Day 21:
- Male Rats = No Evidence
- Female Rats = Equivocal Evidence
- Dose: 0, 5, 100, or 500 ppm.
- TR-545 (NIH Number: 08-4430)
(Peer Review Approval 06/12/2006A )
Organ Systems Toxicity
- Multigenerational Screen (Dosed-Feed)
(MG96005)
Completed
- NIH Number: 08-4477
Citation: Multigenerational Reproductive Toxicology Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study) - Male and Female Rats: Sprague Dawley
- Reproductive Dose Range Finding (On Test)
- Days of Treatment: 28 DAYS
- Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
- Immunotoxicity (On Test)
- Days of Treatment: 4 WEEKS
- Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
- Behavioral Toxicity (On Test)
- Days of Treatment: 10 WEEKS
- Dose: 0, 25, 250, OR 1250 PPM
- Multigeneration Reproductive Study (F0) (On Test)
- Days of Treatment: 20 WEEKS
- Dose: 0, 5, 100, OR 500 PPM
- Multigeneration Reproductive Study (F1) (On Test)
- Days of Treatment: 20 WEEKS
- Dose: 0, 5, 100, OR 500 PPM
- Multigeneration Reproductive Study (F2) (On Test)
- Days of Treatment: 20 WEEKS
- Dose: 0, 5, 100, OR 500 PPM
- Multigeneration Reproductive Study (F3) (On Test)
- Days of Treatment: 20 WEEKS
- Dose: 0, 5, 100, OR 500 PPM
- Multigeneration Reproductive Study (F4) (On Test)
- Days of Treatment: 20 WEEKS
- Dose: 0, 5, 100, OR 500 PPM
- Cancer Study (F1) (On Test)
- Days of Treatment: 2 YEARS
- Dose: 0, 5, 100, OR 500 PPM
- Cancer Study (F3) (On Test)
- Days of Treatment: 2 YEARS
- Dose: 0, 5, 100, OR 500 PPM
- NIH Number: 08-4477