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Testing Status of Water disinfection model (Dichloroacetic acid) M970061

 

CASRN: 79-43-6

Formula: C2-H2-Cl2-O2

Synonyms/Common Names

  • Bichloroacetic acid
  • Dichloracetic acid
  • Dichloroacetic acid (Water disinfection mode)
  • Dichloroethanoic acid

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97013D)  Completed 
    • Mice: FVB/N
    • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013C)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Carcinogenesis Results
      • Male No Evidence 
      • Female No Evidence 
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 41 weeks (Dosed-Water)  (C97013C)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Carcinogenesis Results
      • Male No Evidence 
      • Female No Evidence 
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 26 weeks (Topical Application)  (C97013D)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 31.25, 125, OR 500 MG/KG.
  • 39 weeks (Topical Application)  (C97013D)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 31.25, 125, OR 500 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013I)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Carcinogenesis Results
      • Male No Evidence 
      • Female No Evidence 
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 41 weeks (Dosed-Water)  (C97013I)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Carcinogenesis Results
      • Male No Evidence 
      • Female No Evidence 
    • Dose: 0, 500, 1000, OR 2000 MG/L.