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Testing Status of Indole-3-carbinol M990063


CASRN: 700-06-1

Formula: C9-H9-N-O

Synonyms/Common Names

  • 1H-Indole-3-methanol (9CI)
  • 3-(Hydroxymethyl)indole

Short-Term Toxicity

  • 90 days (Gavage)  (C20006)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 18.75, 37.5, 75, 150, or 300 mg/kg; 20/sex/dose M: 0, 15.6, 31.25, 62.5, 125, or 250 mg/kg; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20006B)  Completed 
    • TR-584   (Peer Review Approval 05/22/2014A )
      Toxicology Studies of Indole-3-Carbinol in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 75, 150, or 300 mg/kg; M: 0, 62.5, 125, or 250 mg/kg; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A31749)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A94530)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A34549)  Completed 
    •  Equivocal 
  • Salmonella  (A35905)  Completed 
    •  Positive