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Testing Status of Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride M050051

 

CASRN: 479500-35-1

Formula: C9-H20-Cl-N

Synonyms/Common Names

  • BMPC
  • [BmPy]Cl
  • 1-Butyl-1-methylpyrrolidinium chloride (ionic liquid)

Short-Term Toxicity

  • 90 days (Dosed-Water)  (C05051)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: MR: 0, 0.3, 1, or 3 mg/mL; FR and FM; 0, 1, 3, or 6 mg/mL; MM: 0, 1, 3, or 10 mg/mL; 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Intravenous; Gavage; Intravenous; Topical Application)  (K03021)  Completed 
    • Citation: Knudsen GA, Cheng Y, Kuester RK, Hooth MJ, Sipes IG. Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats. Drug Metab Dispos. 2009 Nov;37(11):2171-2177. doi: 10.1124/dmd.109.029082. Epub 2009 Aug 24.Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg. 5 mg/kg.
  • C. elegans  (W05051)  Completed 
    • C. elegans
    • Dose: Feeding:0, 1, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100mM; Repro:0, 8, 16, 32, 48, 64, 80, 96, 112, 128, 144, 160mM; Growth:0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100mM.

Genetic Toxicology

  • Salmonella  (A74446)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (I05051)  Completed 
    • Female Mice: BALB/c
    • Dose: 1.65%, 3.125%, 6.25% or 12.5%.