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Testing Status of Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride M050051

 

CASRN: 479500-35-1

Formula: C9-H20-Cl-N

Synonyms/Common Names

  • BMPC
  • [BmPy]Cl
  • 1-Butyl-1-methylpyrrolidinium chloride (ionic liquid)

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C05051B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 1, 3, 6 mg/ml. M: 3, 6, 10 mg/ml. Common Controls for all studies.
  • 90 days (Dosed-Water)  (C05051)  Completed 
    • TOX-103 
      Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: MR: 0, 0.3, 1, or 3 mg/ml. FR and FM: 0, 1, 3, or 6 mg/ml. MM: 0, 1, 3, or 10 mg/ml. 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Intravenous; Gavage; Intravenous; Topical Application)  (K03021)  Completed 
    • Citation: Knudsen GA, Cheng Y, Kuester RK, Hooth MJ, Sipes IG. Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats. Drug Metab Dispos. 2009 Nov;37(11):2171-2177. doi: 10.1124/dmd.109.029082. Epub 2009 Aug 24.Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: (gavage) 0.5, 5.0, 50 mg/kg. (intravenous or topical) 5 mg/kg.
  • C. elegans  (W05051)  Completed 
    • C. elegans
    • Dose: Feeding: 0, 1, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 mM. Repro: 0, 8, 16, 32, 48, 64, 80, 96, 112, 128, 144, 160 mM. Growth: 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 mM.

Genetic Toxicology

  • Micronucleus  (G03021)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Positive 
    • Female Negative 
  • Micronucleus  (G03021B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A74446)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (I05051)  Completed 
    • Citation: Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 2022 Mar;42(3):392-408. https://doi.org/10.1002/jat.4224. Epub 2021 Aug 28.
    • Female Mice: BALB/c
    • Dose: 1.65%, 3.125%, 6.25% or 12.5%.