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Testing Status of Ionic Liquid: N-Butylpyridinium Chloride M050052

 

CASRN: 1124-64-7

Formula: C9 H14 ClN

Synonyms/Common Names

  • NBPC
  • [NBuPy]Cl
  • N-Butylpyridinium chloride (ionic liquid)

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C05052B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 1, 3, 6 mg/ml. M: 1, 3, 6 mg/ml. Common Controls for all studies.
  • 90 days (Dosed-Water)  (C05052)  Completed 
    • TOX-103 
      Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 0.3, 1 or 3 mg/ml. M: 0, 1, 3 or 6 mg/ml. 10/sex/species.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Gavage; Topical Application; Intravenous)  (K03020)  Completed 
    • Citation: Cheng Y, Martinez-Guerrero LJ, Wright SH, Kuester RK, Hooth MJ, Sipes IG. Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo. Drug Metab Dispos. 2011 Sep;39(9):1755-61. doi: 10.1124/dmd.110.035865. Epub 2011 Jun 6.Pubmed Abstract
    • Citation: Cheng Y, Wright SH, Hooth MJ, Sipes IG. Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos. 2009 Apr;37(4):909-16. doi: 10.1124/dmd.108.022681. Epub 2009 Jan 26.Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg [R,M]. 5 mg/kg [R,M].
  • C. elegans  (W05052)  Completed 
    • C. elegans
    • Dose: Feeding: 0, .25, .1, 2, 3, 4, 5, 6, 7, 8, 9, 10 mM. Repro: 2.5, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mM. Growth: 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 mM.

Genetic Toxicology

  • Micronucleus  (G03020)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (G03020B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A75013)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (I05052)  Completed 
    • Citation: Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 2022 Mar;42(3):392-408. https://doi.org/10.1002/jat.4224. Epub 2021 Aug 28.
    • Female Mice: BALB/c
    • Dose: 1.65%, 3.125%, 6.25% or 12.5%.