Testing Status of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride M070018

CASRN: 65039-09-0

Formula: C6-H11-Cl-N2

Synonyms/Common Names

• Basionic (TM) ST 80
• 1-Ethyl-3-methylimidazolium Chloride (Ionic Liquid)

Short-Term Toxicity

• 14 days (Dosed-Water)  (C07018B)  Completed 
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
  • Dose: R: 3, 10, 30, 100 mg/ml. M: 3, 10, 30, 100 mg/ml. Common Controls for all studies.
• 90 days (Dosed-Water)  (C07018)  Completed 
  • TOX-103 
    Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
  • Dose: R: 0, 1 3, or 10 mg/ml. M: 0, 3, 10 or 30 mg/ml. 10/sex/species.

Special Studies

• C. elegans  (W07018)  Completed 
  • C. elegans
  • Dose: Feeding: 0, 1, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40 mM. Repro: 0, 3.5, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70 mM. Growth: 0, 3, 6, 12, 18, 24, 30, 36, 42, 48, 54, 60 mM.

Genetic Toxicology

• Micronucleus  (G07018)  Completed 
  • Male & Female Sprague Dawley Rats
  • Rats: Harlan Sprague-Dawley
  • Male Negative 
  • Female Negative 
• Micronucleus  (G07018B)  Completed 
  • Male & Female B6C3F1 Mice
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A09944)  Completed 
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (I07018)  Completed 
  • Citation: Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 2022 Mar;42(3):392-408. https://doi.org/10.1002/jat.4224. Epub 2021 Aug 28.
  • Female Mice: BALB/c
  • Dose: 0, 6.25, 12.5, 25, or 50%.