The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) is a federally chartered advisory committee established on January 9, 2002, in response to the ICCVAM Authorization Act of 2000. SACATM replaces the Advisory Committee on Alternative Toxicological Methods (ACATM). SACATM advises the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the Director of the NIEHS regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, implementation, and national and international harmonization of new, revised, and alternative toxicological test methods. Alternative methods are those that reduce, refine (lessen or avoid pain and/or distress), or replace the use of animals in testing. SACATM also provides input on ways to foster partnerships and communication with interested parties. The NIEHS Director appoints voting members to the SACATM and membership is defined in the ICCVAM Authorization Act of 2000 to include representatives from academia, state government, industry, and animal protection organizations. The SACATM typically meets once a year.
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