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https://ntp.niehs.nih.gov/go/40440

Trimethylolpropane triacrylate: Target Organs and Levels of Evidence for GMM-03

Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)

Chemical (Study Title)
CASRN 		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Trimethylolpropane triacrylate
15625-89-5 		09/06/2002Topical Application
0, 0.75, 1.5, 3, 6, or 12 mg/kg; 15/sex/dose		Battelle Columbus Laboratory

Levels of evidence information for toxicology and genetic toxicology studies of Trimethylolpropane Triacrylate (Technical Grade) in Tg.AC Hemizygous Mice
Male Tg.AC Hemizygous MiceFemale Tg.AC Hemizygous Mice
26 Weeks26 Weeks
Neoplastic Lesions
  • Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 2/15, 12/15, 13/15)
  • Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 1/15, 11/15, 15/15); squamous cell carcinoma (0/15, 0/15, 1/15, 0/15, 1/15, 1/15)
May Have Been Related
  • None
  • Forestomach: squamous cell papilloma (4/15, 5/15, 4/15, 2/15, 5/15, 9/15)
Non-Neoplastic Lesions
  • Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
  • All organs: myelodysplasia
  • Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
  • All organs: myelodysplasia