Trimethylolpropane triacrylate: Target Organs and Levels of Evidence for GMM-03
Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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Trimethylolpropane triacrylate 15625-89-5 | 09/06/2002 | Topical Application 0, 0.75, 1.5, 3, 6, or 12 mg/kg; 15/sex/dose | Battelle Columbus Laboratory |
Levels of evidence information for toxicology and genetic toxicology studies of Trimethylolpropane Triacrylate (Technical Grade) in Tg.AC Hemizygous Mice | Male Tg.AC Hemizygous Mice | Female Tg.AC Hemizygous Mice |
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| 26 Weeks | 26 Weeks |
Neoplastic Lesions | - Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 2/15, 12/15, 13/15)
| - Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 1/15, 11/15, 15/15); squamous cell carcinoma (0/15, 0/15, 1/15, 0/15, 1/15, 1/15)
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May Have Been Related | | - Forestomach: squamous cell papilloma (4/15, 5/15, 4/15, 2/15, 5/15, 9/15)
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Non-Neoplastic Lesions | - Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
- All organs: myelodysplasia
| - Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
- All organs: myelodysplasia
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