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Water disinfection model (Sodium bromate): Target Organs and Levels of Evidence for GMM-06

Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Water disinfection model (Sodium bromate) 7789-38-0	09/27/2005	Dosed-Water 0, 80, 400, or 800 mg/L	Battelle Columbus Laboratory

Levels of evidence information for Carcinogenesis and Genetic Toxicology Studies of Sodium Bromate in P53 Haploinsufficient Mice
	Male P53 Haploinsufficient Mice		Female P53 Haploinsufficient Mice
	27 Weeks	43 Weeks	27 Weeks	43 Weeks
Levels of Evidence	No Evidence	No Evidence	No Evidence	No Evidence
Neoplastic	None	None	None	None
Non-Neoplastic	None	None	None	None

Levels of evidence information for Drinking Water and Genetic Toxicology Studies of Sodium Bromate in Tg.AC Hemizygous Mice
	Male Tg.AC Hemizygous Mice		Female Tg.AC Hemizygous Mice
	27 Weeks	43 Weeks	27 Weeks	43 Weeks
Neoplastic	None	None	None	None
Non-Neoplastic Lesions	Thyroid gland: follicular cell hypertrophy; follicular secretory depletion Kidney: nephropathy; tubule degeneration	Thyroid gland: follicular cell hypertrophy; lymphocytic cellular infiltrates Kidney: tubule degeneration; tubule hypertrophy Epididymis: degeneration Testes: germinal epithelium degeneration	Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates Kidney: nephropathy; tubule degeneration; tubule hypertrophy Pituitary gland: par distalis hypertrophy	Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates Kidney: tubule degeneration; tubule hypertrophy Pituitary gland: par distalis hypertrophy

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Water disinfection model (Sodium bromate) 7789-38-0	09/27/2005	Topical Application 0, 64, 128, or 256 mg/kg	Battelle Columbus Laboratory

Levels of evidence information for Dermal and Genetic Toxicology Studies of Sodium Bromate in Tg.AC Hemizygous Mice
	Male Tg.AC Hemizygous Mice		Female Tg.AC Hemizygous Mice
	26 Weeks	39 Weeks	26 Weeks	39 Weeks
Neoplastic	None	None	None	None
Non-Neoplastic Lesions	Thyroid gland: follicular cell hypertrophy Kidney: nephropathy	Thyroid gland: follicular cell hypertrophy Testes: germinal epithelium degeneration	Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates Kidney: nephropathy Spleen: hematopoietic cell proliferation	Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates Kidney: hypertrophy