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https://ntp.niehs.nih.gov/go/18979

Water disinfection model (Sodium bromate): Target Organs and Levels of Evidence for GMM-06

Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Water disinfection model (Sodium bromate)
7789-38-0 		09/27/2005 Dosed-Water
0, 80, 400, or 800 mg/L		 Battelle Columbus Laboratory

Levels of evidence information for Carcinogenesis and Genetic Toxicology Studies of Sodium Bromate in P53 Haploinsufficient Mice
  Male P53 Haploinsufficient Mice Female P53 Haploinsufficient Mice
  27 Weeks 43 Weeks 27 Weeks 43 Weeks
Levels of Evidence No Evidence No Evidence No Evidence No Evidence
Neoplastic None None None None
Non-Neoplastic None None None None

Levels of evidence information for Drinking Water and Genetic Toxicology Studies of Sodium Bromate in Tg.AC Hemizygous Mice
  Male Tg.AC Hemizygous Mice Female Tg.AC Hemizygous Mice
  27 Weeks 43 Weeks 27 Weeks 43 Weeks
Neoplastic None None None None
Non-Neoplastic Lesions
  • Thyroid gland: follicular cell hypertrophy; follicular secretory depletion
  • Kidney: nephropathy; tubule degeneration
  • Thyroid gland: follicular cell hypertrophy; lymphocytic cellular infiltrates
  • Kidney: tubule degeneration; tubule hypertrophy
  • Epididymis: degeneration
  • Testes: germinal epithelium degeneration
  • Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates
  • Kidney: nephropathy; tubule degeneration; tubule hypertrophy
  • Pituitary gland: par distalis hypertrophy
  • Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates
  • Kidney: tubule degeneration; tubule hypertrophy
  • Pituitary gland: par distalis hypertrophy




Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Water disinfection model (Sodium bromate)
7789-38-0 		09/27/2005 Topical Application
0, 64, 128, or 256 mg/kg		 Battelle Columbus Laboratory


Levels of evidence information for Dermal and Genetic Toxicology Studies of  Sodium Bromate in Tg.AC Hemizygous Mice
  Male Tg.AC Hemizygous Mice Female Tg.AC Hemizygous Mice
  26 Weeks 39 Weeks 26 Weeks 39 Weeks
Neoplastic None None None None
Non-Neoplastic Lesions
  • Thyroid gland: follicular cell hypertrophy
  • Kidney: nephropathy
  • Thyroid gland: follicular cell hypertrophy
  • Testes: germinal epithelium degeneration
  • Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates
  • Kidney: nephropathy
  • Spleen: hematopoietic cell proliferation
  • Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates
  • Kidney: hypertrophy