Water disinfection model (Sodium bromate): Target Organs and Levels of Evidence for GMM-06
Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Water disinfection model (Sodium bromate) 7789-38-0 | 09/27/2005 | Dosed-Water 0, 80, 400, or 800 mg/L | Battelle Columbus Laboratory |
Levels of evidence information for Carcinogenesis and Genetic Toxicology Studies of Sodium Bromate in P53 Haploinsufficient Mice | Male P53 Haploinsufficient Mice | Female P53 Haploinsufficient Mice |
| 27 Weeks | 43 Weeks | 27 Weeks | 43 Weeks |
Levels of Evidence | No Evidence | No Evidence | No Evidence | No Evidence |
Neoplastic | None | None | None | None |
Non-Neoplastic | None | None | None | None |
Levels of evidence information for Drinking Water and Genetic Toxicology Studies of Sodium Bromate in Tg.AC Hemizygous Mice | Male Tg.AC Hemizygous Mice | Female Tg.AC Hemizygous Mice |
| 27 Weeks | 43 Weeks | 27 Weeks | 43 Weeks |
Neoplastic | None | None | None | None |
Non-Neoplastic Lesions | - Thyroid gland: follicular cell hypertrophy; follicular secretory depletion
- Kidney: nephropathy; tubule degeneration
| - Thyroid gland: follicular cell hypertrophy; lymphocytic cellular infiltrates
- Kidney: tubule degeneration; tubule hypertrophy
- Epididymis: degeneration
- Testes: germinal epithelium degeneration
| - Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates
- Kidney: nephropathy; tubule degeneration; tubule hypertrophy
- Pituitary gland: par distalis hypertrophy
| - Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates
- Kidney: tubule degeneration; tubule hypertrophy
- Pituitary gland: par distalis hypertrophy
|
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Water disinfection model (Sodium bromate) 7789-38-0 | 09/27/2005 | Topical Application 0, 64, 128, or 256 mg/kg | Battelle Columbus Laboratory |
Levels of evidence information for Dermal and Genetic Toxicology Studies of Sodium Bromate in Tg.AC Hemizygous Mice | Male Tg.AC Hemizygous Mice | Female Tg.AC Hemizygous Mice |
| 26 Weeks | 39 Weeks | 26 Weeks | 39 Weeks |
Neoplastic | None | None | None | None |
Non-Neoplastic Lesions | - Thyroid gland: follicular cell hypertrophy
- Kidney: nephropathy
| - Thyroid gland: follicular cell hypertrophy
- Testes: germinal epithelium degeneration
| - Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular infiltrates
- Kidney: nephropathy
- Spleen: hematopoietic cell proliferation
| - Thyroid gland: follicular cell hypertrophy; follicular secretory depletion; lymphocytic cellular Infiltrates
- Kidney: hypertrophy
|