https://ntp.niehs.nih.gov/go/36762

Senna (powdered): Target Organs and Levels of Evidence for GMM-15

Toxicology Study of Senna (CASRN 8013-11-4) in C57BL/6NTAC Mice and Toxicology and Carcinogenesis Study of Senna in Genetically Modified C3B6.129F1/Tac-Trp53tm1Brd  N12 Haploinsufficient Mice (Feed Studies)

Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Senna (powdered)
8013-11-4 		04/05/2011 Dosed-Feed
0, 100, 300, 1000, 3000, or 10,000 ppm; 25/sex		 Battelle Columbus Laboratory

Levels of evidence information for the 40-Week Carcinogenesis and Genetic Toxicology Studies of Senna
  Male Heterozygous F1 p53+/− Mice Female Heterozygous F1 p53+/− Mice
  40 Weeks 40 Weeks
Levels of Evidence No evidence No evidence
Neoplastic Lesions None None
Non-Neoplastic Lesions
  • Large intestine (cecum): epithelial hyperplasia
  • Large intestine (colon): epithelial hyperplasia
  • Large intestine (cecum): epithelial hyperplasia
  • Large intestine (colon): epithelial hyperplasia