TDMS Study 96003-03 Pathology Tables
NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 FINAL#1/MICE Facility: BIORELIANCE Chemical CAS #: 106-95-6 Lock Date: 10/18/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 008 VEHICLE CONTROL Include 009 0.5 MG/KG Include 010 1 MG/KG Include 011 2 MG/KG Include 012 4 MG/KG Include 013 8 MG/KG Include 001 VEHICLE CONTROL Include 002 0.5 MG/KG Include 003 1 MG/KG Include 004 2 MG/KG Include 005 4 MG/KG Include 006 8 MG/KG Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + | 2 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | I + + + A + + + A + + + + + A | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + A + + + + + + | 14 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X X X | 3 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Tooth | + + | 2 | Odontogenic Tumor | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + A + + M + + A | 11 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + A + + + + + A | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + A + + + + + A | 13 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + A + + + + + A | 13 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + A + + + + + A | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Lip, Squamous Cell Papilloma | X | 1 | Vulva, Squamous Cell Papilloma | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + A + + + + + + | 14 | |__________________________________________________________________________|____________| Trachea | M | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X X X X X | 8 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + | 1 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + A + + + | 14 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + A + + + | 14 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + A A + + + | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + A + + + + | 14 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + A + + + + | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Erythrocytic | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + I + + + + A + + + + | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Lip, Squamous Cell Papilloma | X | 1 | Vulva, Squamous Cell Papilloma | X X X X | 4 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Erythrocytic | X | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + A + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + A + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + A A + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 3 | Duct, Carcinoma | X X X | 3 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + A + + + + + + + + + A A | 12 | Squamous Cell Papilloma | X X X X | 4 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Tooth | + + + + + + | 6 | Odontogenic Tumor | X X X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + A A + | 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A A + | 13 | |__________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + A M | 12 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + A + + + + + + + + A A + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + A + + + + + + + + A A + | 12 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X | 3 | Vulva, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + A | 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + A + + + + + + + + + A + + | 13 | Squamous Cell Papilloma | X X X X X X X | 7 | |__________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Tooth | + + + + + + + | 7 | Odontogenic Tumor | X X X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + A A + + + + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + A A + + + + + + + + + M + + | 12 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + M + + + + + + | 13 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + A + + + + + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + M + + | 14 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A + + | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + M + + | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Vulva, Squamous Cell Papilloma | X X X X X | 5 | Vulva, Squamous Cell Papilloma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Adenoma | X X | 2 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Pancreas | + + + | 3 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + A + | 14 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + + + + A + | 13 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + A + A + + + A + | 12 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + A + A + + + A + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + A + + A + | 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + M + + + A + | 13 | |__________________________________________________________________________|____________| Oviduct | A | | |__________________________________________________________________________|____________| Uterus | + + + + + + + A + + A + + A + | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + A + + A + + A + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + A + + A + + A + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + A + + A + + A + | 12 | |__________________________________________________________________________|____________| Spleen | + + + + + + + A + + + + + A + | 13 | |__________________________________________________________________________|____________| Thymus | + + + + + + + A + A A + + A + | 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + A + | 14 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X | 1 | Lip, Squamous Cell Papilloma | X | 1 | Vulva, Squamous Cell Papilloma | X X X X | 4 | Vulva, Squamous Cell Papilloma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + A + + + + + A + | 13 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X X X | 6 | Squamous Cell Papilloma, Multiple | X X X X | 4 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + M + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + M + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + I | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Dermis, Fibrosarcoma | X | 1 | Lip, Squamous Cell Papilloma | X X X | 3 | Vulva, Squamous Cell Papilloma | X X X X X X | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Vulva, Squamous Cell Papilloma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + | 1 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + + + | 5 | Odontogenic Tumor | X X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Penis | + + + | 3 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X | 4 | Squamous Cell Papilloma, Multiple | X | 1 | Lip, Squamous Cell Papilloma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Duct, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 | Squamous Cell Papilloma | X X X | 3 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + + | 5 | Odontogenic Tumor | X X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Islets, Pancreatic | + | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A + + + + A + + + | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + I + + A + + + | 13 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Lip, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Carcinoma | X | 1 | |__________________________________________________________________________|____________| Trachea | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + A + + + | 14 | Leukemia Erythrocytic | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Duct, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Cortex | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + I + + + A + + A | 12 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | Leukemia Erythrocytic | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + M + + A | 12 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Keratoacanthoma | X X X | 3 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X X | 2 | Lip, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + A + + + | 14 | Carcinoma, Metastatic, Salivary | | | Glands | X | 1 | Leukemia Erythrocytic | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Mesentery | + + | 2 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Duct, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X X | 5 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + I + + + + + A + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X | 2 | Squamous Cell Papilloma, Multiple | X | 1 | Lip, Squamous Cell Papilloma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + A + + + + + + + + | 14 | Leukemia Erythrocytic | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | A | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + A + + + + A + + + | 13 | Squamous Cell Papilloma | X X X X X | 5 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Tooth | + + + + + + | 6 | Odontogenic Tumor | X X X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Cortex | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + I + + + + A + + A M I I + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + M + + + A + + A A A A + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + | 4 | |__________________________________________________________________________|____________| Testes | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + A + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + + A A A M + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + | 14 | Leukemia Erythrocytic | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Thymus | M + + + + M A + + A A + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + A + + + + + + + + | 14 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | X | 1 | Conjunctiva, Squamous Cell Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + A + + + + + + + + | 14 | Alveolar/Bronchiolar Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + A + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + | 14 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + A + + + + + + + + | 14 | Squamous Cell Papilloma | X X X X X | 5 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Cortex | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + A + M + + + + + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 96003-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:09 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + + + I + A + + + + + + + + | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | X X X | 3 | Lip, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + A + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------