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TDMS Study 96003-03 Pathology Tables

NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01
Route: GAVAGE                                                                                                     Time: 09:19:14

                                                          FINAL#1/MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  106-95-6

       Lock Date:  10/18/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 008    VEHICLE CONTROL
                               Include 009    0.5     MG/KG
                               Include 010    1 MG/KG
                               Include 011    2 MG/KG
                               Include 012    4 MG/KG
                               Include 013    8 MG/KG
                               Include 001    VEHICLE CONTROL
                               Include 002    0.5     MG/KG
                               Include 003    1 MG/KG
                               Include 004    2 MG/KG
                               Include 005    4 MG/KG
                               Include 006    8 MG/KG

























                                                              Page   1


NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6|                             |            |
                                           | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                             |      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |             +        +                                                   |   2        |
      Muscularis, Epithelium, Necrosis,    |                                                                          |            |
           Diffuse                         |             4                                                            |      1  4.0|
      Muscularis, Periesophageal Tissue,   |                                                                          |            |
           Inflammation, Chronic Active,   |                                                                          |            |
           Focal                           |                      3                                                   |      1  3.0|
      Periesophageal Tissue, Foreign Body, |                                                                          |            |
           Focal                           |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | I  +  +  +  A  +  +  +  A  +  +  +  +  +  A                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     |          1                                                               |      1  1.0|
      Necrosis, Focal                      |                         2              2                                 |      2  2.0|
      Hepatocyte, Necrosis, Focal          |       1                                                                  |      1  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             | 3  1  2                    2                                             |      4  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                1                    1                                    |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6|                             |            |
                                           | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                             |      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                      +           +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
      Aorta, Inflammation, Chronic Active, |                                                                          |            |
           Focal                           |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
      Atrophy                              |                      1     1        2  2                                 |      4  1.5|
      Subcapsular, Hyperplasia, Focal      |                   1              1                                       |      2  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             |          2           2     4  3     4  3                                 |      6  3.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |    2  1     1  2  1              1                                       |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  A  +  +  M  +  +  A                              |  11        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
      Follicle, Cyst, Focal                |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6|                             |            |
                                           | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                             |      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Degeneration                         |                                        2                                 |      1  2.0|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active, Diffuse                  |          4                                                               |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active, Diffuse         |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
      Endometrium, Hyperplasia, Cystic     | 1  2  2  2     3     2     3  3  1  2  3                                 |     11  2.2|
      Endometrium, Inflammation, Acute,    |                                                                          |            |
           Focal                           |                                        4                                 |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
      Hyperplasia                          |                      2           2                                       |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
      Hyperplasia                          |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 2  2  2  3  1  2     3  3  2  2  2  2  2                                 |     13  2.2|
      Pigmentation                         | 1  1  1  1     1     1     1  1     1  1                                 |     10  1.0|
      Lymphoid Follicle, Depletion Cellular|             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A                              |  13        |
      Atrophy, Diffuse                     |          2  4     4  4           3                                       |      5  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                                           +                              |   1        |
      Dilatation, Focal                    |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6|                             |            |
                                           | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                             |      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +                              |  14        |
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Focal                           |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 |                   M                                                      |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Bilateral, Inflammation, Acute, Focal|                         4                                                |      1  4.0|
      Bilateral, Nephropathy, Diffuse      | 4                                                                        |      1  4.0|
      Cortex, Pelvis, Inflammation,        |                                                                          |            |
          Chronic Active, Focal            |                                  3                                       |      1  3.0|
      Renal Tubule, Dilatation, Diffuse    |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                             |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Necrosis, Focal                      |          2                    1                                          |      2  1.5|
      Hepatocyte, Necrosis, Focal          |                         1                                                |      1  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             | 2  2                                2  2  3                              |      5  2.2|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |       2     1                                                            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                                     +                                    |   1        |
      Necrosis, Focal                      |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +              +  +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                             |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Atrophy                              | 2  1                    2  1        2     2                              |      6  1.7|
      Subcapsular, Hyperplasia, Focal      | 1  2        1              1                                             |      4  1.3|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             | 3  3     3  3     3  3        2     3                                    |      8  2.9|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |       2                 1  1              1                              |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +                              |  13        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Angiectasis, Focal                   |                         1                                                |      1  1.0|
      Atrophy                              |                         2  2                                             |      2  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active, Focal           |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hydrometra                           |          1                                                               |      1  1.0|
      Inflammation, Acute, Diffuse         |                               4                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  1     2     3  1     3        2  1  1                              |     10  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                             |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy                              |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                              |  14        |
      Hematopoietic Cell Proliferation     | 2  1  3  2  2     2     2  2        2  2  2                              |     11  2.0|
      Pigmentation                         | 1  1  1  1  1     1  1     1        1  1  1                              |     11  1.0|
      Lymphoid Follicle, Depletion Cellular|                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  I  +  +  +  +  A  +  +  +  +                              |  13        |
      Atrophy, Diffuse                     |                      3  3        3                                       |      3  3.0|
      Atrophy, Focal                       |             2                             1                              |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Serosa, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active, Focal           |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                             |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Cortex, Inflammation, Acute, Focal   |                               3                                          |      1  3.0|
      Renal Tubule, Degeneration, Focal    |    1                                                                     |      1  1.0|
      Renal Tubule, Dilatation, Diffuse    |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1|                             |            |
                             DAY ON TEST   | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6|                             |            |
                                           | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  A  A  A                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  A  A  A                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
      Inflammation, Acute, Focal           |                      1                                                   |      1  1.0|
      Inflammation, Chronic Active, Diffuse|          4                                                               |      1  4.0|
      Necrosis, Focal                      |          3                          3  2                                 |      3  2.7|
      Hepatocyte, Degeneration, Focal      |                                     2                                    |      1  2.0|
      Hepatocyte, Necrosis, Focal          |                         1        1        1                              |      3  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |    3              1           3                                          |      3  2.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                      1                                                   |      1  1.0|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                         +                                                |   1        |
      Acinus, Atrophy, Diffuse             |                         4                                                |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |       +              +                    +                              |   3        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  A  A                              |  12        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1|                             |            |
                             DAY ON TEST   | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6|                             |            |
                                           | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  A  A  A                              |  11        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +  +  +              +           +                                 |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  A  +  +  +  +  +  +  +  +  +  A  A                              |  12        |
      Atrophy                              | 2  1  2     1     2     2  2  1  2                                       |      9  1.7|
      Subcapsular, Hyperplasia, Focal      |    1           1              1                                          |      3  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             | 2                 2     3  3     3  3                                    |      6  2.7|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |    2  2     1        1        1                                          |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  A  +  +  +  +  +  +  +  +  +  A  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  A  A  +                              |  12        |
      Ectopic Thymus                       |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  14        |
      Atrophy                              | 2              3                                                         |      2  2.5|
      Cyst                                 |                                  4                                       |      1  4.0|
      Degeneration                         |          2        1                                                      |      2  1.5|
      Corpus Luteum, Inflammation, Chronic |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1|                             |            |
                             DAY ON TEST   | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6|                             |            |
                                           | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
          Active, Focal                    |                            4                                             |      1  4.0|
      Periovarian Tissue, Rete Ovarii,     |                                                                          |            |
           Inflammation, Acute, Focal      |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +                              |  13        |
      Inflammation, Acute, Focal           |             2                                                            |      1  2.0|
      Inflammation, Chronic Active, Diffuse|          4                                                               |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 1  2  3           2     1  1  3  2                                       |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   1        |
      Inflammation, Chronic Active, Diffuse|          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  A  M                              |  12        |
      Inflammation, Acute, Focal           |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +                              |  14        |
      Hyperplasia                          |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 2  2  2  3  4  2  3  2  3  2  2  2  4  3  2                              |     15  2.5|
      Pigmentation                         | 2  1  1        1  1     1  1  1  1        1                              |     10  1.1|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +                              |  12        |
      Atrophy, Focal                       |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Dermis, Fibrosis, Focal              |             3                                                            |      1  3.0|
      Dermis, Subcutaneous Tissue,         |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1|                             |            |
                             DAY ON TEST   | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6|                             |            |
                                           | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Diffuse                         |             2                                                            |      1  2.0|
      Epidermis, Hyperplasia, Focal        |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolus, Hyperplasia, Focal,        |                                                                          |            |
          Histiocytic                      |    1                                                                     |      1  1.0|
      Arteriole, Necrosis, Focal           |                                     3                                    |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
      Inflammation, Chronic Active, Focal  |          3                                                               |      1  3.0|
      Necrosis, Focal                      |                                     3                                    |      1  3.0|
      Capsule, Inflammation, Acute, Focal  |                                        1                                 |      1  1.0|
      Renal Tubule, Dilatation, Diffuse    |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7|                             |            |
                                           | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    2 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     |                         1                                                |      1  1.0|
      Necrosis, Focal                      |    2  3                                                                  |      2  2.5|
      Hepatocyte, Necrosis, Focal          | 1           1     1     1        1                                       |      5  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |          1     1                 2     1                                 |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +           +     +     +        +                                 |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   |                                     +                                    |   1        |
      Atrium, Thrombosis, Focal            |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +                              |  13        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7|                             |            |
                                           | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    2 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Atrophy                              |                         2        1        1                              |      3  1.3|
      Subcapsular, Hyperplasia, Focal      | 1           1  1  1  1        1  1     1  1                              |      9  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             | 3        3  3     2  2     3     3  3  2  2                              |     10  2.6|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |                         2     1                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A  A  +  +  +  +  +  +  +  +  +  M  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  +  +  +  +  M  +  +  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                              |  14        |
      Degeneration                         |                            2                                             |      1  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active, Focal           |                         4                                                |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  14        |
      Hydrometra                           |          3           3                                                   |      2  3.0|
      Endometrium, Hyperplasia, Cystic     | 2           2     2              1                                       |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7|                             |            |
                                           | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    2 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 3  3  2  2  2  2  2  3  2     2  3     1  1                              |     13  2.2|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  2  1  1     1  1                              |     14  1.1|
      Lymphoid Follicle, Depletion Cellular|       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +                              |  13        |
      Atrophy, Diffuse                     |       4                    4                                             |      2  4.0|
      Atrophy, Focal                       |          2  2                 2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolus, Hemorrhage, Focal          |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Papilla, Inflammation, Acute, Focal  |                         2                                                |      1  2.0|
      Renal Tubule, Dilatation, Focal      |                      1                 1                                 |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
      Serosa, Inflammation, Acute, Focal   | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +                              |  14        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Polymorphonuclear                |                      3                                                   |      1  3.0|
      Inflammation, Acute, Focal           | 3                                                                        |      1  3.0|
      Necrosis, Chronic Active, Focal      |                               3                                          |      1  3.0|
      Necrosis, Focal                      | 2                                                                        |      1  2.0|
      Hepatocyte, Necrosis, Focal          |             1  1                          1                              |      3  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |    2        2           2           4                                    |      4  2.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                                  2        1                              |      2  1.5|
      Serosa, Inflammation, Acute, Focal   |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +                          +                                          |   3        |
      Inflammation, Acute, Diffuse         | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +                              |  14        |
      Muscularis, Serosa, Inflammation,    |                                                                          |            |
           Acute, Focal                    | 4                                                                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +                              |  13        |
      Serosa, Inflammation, Acute, Focal   | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                          +  +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +                              |  12        |
      Atrophy                              | 1  1  1  1  2  2  2     2        1  2     2                              |     11  1.5|
      Subcapsular, Hyperplasia, Focal      |    1  1     2     1              1                                       |      5  1.2|
      Zona Reticularis, Hyperplasia,       |                                                                          |            |
          Diffuse                          |                4                                                         |      1  4.0|
      Zona Reticularis, Infiltration       |                                                                          |            |
          Cellular, Focal, Lymphocyte      | 1                                                                        |      1  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             | 2  2  3  2        4     4        2  4     2                              |      9  2.8|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  A  +  +  A  +                              |  12        |
      Ectopic Thymus                       |                         1                                                |      1  1.0|
      Follicle, Cyst, Focal                |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  A  +                              |  13        |
      Atrophy                              |                                     2                                    |      1  2.0|
      Cyst                                 |                2                                                         |      1  2.0|
      Degeneration                         |                2                                                         |      1  2.0|
      Inflammation, Acute, Diffuse         | 4                                                                        |      1  4.0|
      Inflammation, Chronic Active, Diffuse|                      4                                                   |      1  4.0|
      Bilateral, Periovarian Tissue, Cyst  |       2                                                                  |      1  2.0|
      Periovarian Tissue, Rete Ovarii,     |                                                                          |            |
           Inflammation, Acute, Focal      | 4                                                                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                      A                                                   |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  A  +  +  A  +  +  A  +                              |  12        |
      Atrophy                              |                            3                                             |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    1  4  3  2  2  3     2        2  1     2                              |     10  2.2|
      Serosa, Inflammation, Acute, Focal   | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
      Iliac, Hyperplasia                   | 3                                                                        |      1  3.0|
      Renal, Hyperplasia                   | 4                                                                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  A  +  +  A  +  +  A  +                              |  12        |
      Hyperplasia                          |                   3     2                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  A  +  +  A  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  A  +  +  A  +  +  A  +                              |  12        |
      Hyperplasia                          | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +                              |  13        |
      Hematopoietic Cell Proliferation     | 4  2  3  2  3  2  3     2  2     2  1     2                              |     12  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pigmentation                         |    1  1  1  1  1  1     1  1     1  1     1                              |     11  1.0|
      Capsule, Inflammation, Acute, Focal  | 4                             4                                          |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  A  +  A  A  +  +  A  +                              |  11        |
      Atrophy, Focal                       |             1                       1                                    |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +                              |  14        |
      Alveolus, Inflammation, Chronic,     |                                                                          |            |
           Focal                           |                            1                                             |      1  1.0|
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Focal                           |                      3                                                   |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +                              |  13        |
      Inflammation, Chronic Active, Focal  |                               4                                          |      1  4.0|
      Renal Tubule, Dilatation, Focal      |                         1                                                |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|                             |            |
                                           | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    8 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Polymorphonuclear                | 4                                                                        |      1  4.0|
      Necrosis, Focal                      | 1     1                                                                  |      2  1.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                   1                                                      |      1  1.0|
      Hepatocyte, Necrosis, Focal          |             1     1  1        1                                          |      4  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                      2  2           2                                    |      3  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    1     1                             1                                 |      3  1.0|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                            1  1                                          |      2  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |             +        +           +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|                             |            |
                                           | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    8 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy                              | 2  1                 1     1                                             |      4  1.3|
      Mineralization, Focal                |                      1                                                   |      1  1.0|
      Subcapsular, Hyperplasia, Focal      |       1  1  1  1        1              1                                 |      6  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Diffuse             | 3  3     2  3  3     2     2  3  2  3  2  3                              |     12  2.6|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |       1           1     2                                                |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Cyst, Focal                          |    3                                                                     |      1  3.0|
      Degeneration                         |          1                                                               |      1  1.0|
      Inflammation, Diffuse                |                   4                                                      |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Acute, Focal                    |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Endometrium, Hyperplasia, Cystic     | 2  4  3  2     1  2  1  2  2  2     2  2  3                              |     13  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|                             |            |
                                           | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    8 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          | 2                    3                                                   |      2  2.5|
      Necrosis, Focal                      | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I                              |  14        |
      Inflammation, Diffuse                | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 4  2  2  1  1  2  2  1  2  2  2     2  2  2                              |     14  1.9|
      Pigmentation                         |    1  1  1  1  1  1  1  1  1  1  1  1  1  1                              |     14  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy, Diffuse                     | 4                                                                        |      1  4.0|
      Atrophy, Focal                       |       1  1  1           2        3        2                              |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |                +        +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolus, Hemorrhage, Focal          |                                  1                                       |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|                             |            |
                                           | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE     | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    8 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                           1                              |      1  1.0|
      Bilateral, Inflammation, Acute, Focal| 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|                             |            |
                                           | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                             |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  14        |
      Hepatocyte, Necrosis, Focal          |             1              1                                             |      2  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |                                        1                                 |      1  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        | 1                 1                                                      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                        +                                 |   1        |
      Fat, Necrosis, Focal                 |                                        4                                 |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +        +        +     +  +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|                             |            |
                                           | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                             |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy                              | 3  2  3  3  3  3  3  2  4  3  3  3  3  3  3                              |     15  2.9|
      Hypertrophy, Focal                   | 1     1  1  1  1  1     1  1  1  1  1  2  2                              |     13  1.2|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Penis                                   |    +                 +        +                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                               +                                          |   1        |
      Ectasia                              |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Germinal Epithelium, Degeneration,   |                                                                          |            |
           Focal                           |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hyperplasia                          |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|                             |            |
                                           | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                             |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 1  1  1  2  1  1  1     1  1  1  1  1  1  1                              |     14  1.1|
      Pigmentation                         | 1     1  1  1  1        1        1  1                                    |      8  1.0|
      Lymphoid Follicle, Depletion Cellular|                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy, Diffuse                     |    3                 2        3                                          |      3  2.7|
      Atrophy, Focal                       |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Epidermis, Hyperplasia, Focal        |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   1        |
      Retina, Atrophy                      |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|                             |            |
                                           | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                             |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Renal Tubule, Dilatation, Focal      |                                     1                                    |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7|                             |            |
                                           | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    0.5                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                             |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |                                        +                                 |   1        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic Active, Focal           |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Necrosis, Focal                      |                   1                                                      |      1  1.0|
      Hepatocyte, Necrosis, Focal          |       1  1                    1                                          |      3  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                         4                                                |      1  4.0|
      Serosa, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Fat, Necrosis, Focal                 | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7|                             |            |
                                           | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    0.5                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                             |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Tooth                                   |          +        +  +  +        +                                       |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Atrophy                              | 3  3  3  3  3  3  1  3  3  3  3     3     3                              |     13  2.8|
      Hypertrophy, Focal                   | 1  1     1  1  1     1     1  1     1     1                              |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |                               +                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
      Inflammation, Chronic Active, Focal  |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                   +                 +                                    |   2        |
      Ectasia                              |                   3                                                      |      1  3.0|
      Inflammation, Chronic Active, Focal  |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7|                             |            |
                                           | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    0.5                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                             |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
      Hyperplasia, Histiocytic             |          2                                                               |      1  2.0|
      Hyperplasia                          |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Hyperplasia                          |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
      Hyperplasia                          |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Congestion                           |                   2                                                      |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  1  2  1  2  1  1  2  1  1  1     2  1  1                              |     14  1.3|
      Pigmentation                         | 1  1     1  1  1        1  1  1     1     1                              |     10  1.0|
      Lymphoid Follicle, Depletion Cellular|                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  +  A  +  +  +                              |  13        |
      Atrophy, Diffuse                     |                   4  4                 3                                 |      3  3.7|
      Atrophy, Focal                       |          2  2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Focal           |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7|                             |            |
                                           | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    0.5                                    | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                             |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                            2                                             |      1  2.0|
      Arteriole, Capillary, Perivascular,  |                                                                          |            |
           Inflammation, Acute             |                      3                                                   |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Focal, Lymphocyte               |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Inflammation, Acute, Focal           |                   3                                                      |      1  3.0|
      Capsule, Cortex, Inflammation,       |                                                                          |            |
          Chronic Active, Focal            |                      4                                                   |      1  4.0|
      Renal Tubule, Dilatation, Focal      |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         |                                  +                                       |   1        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1|                             |            |
                             DAY ON TEST   | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1|                             |            |
                                           | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  A                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  A  +  +  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  +  +  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  A  +  +  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Hepatocyte, Necrosis, Focal          | 1        1        1           1        1                                 |      5  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |    1           2                                                         |      2  1.5|
      Sinusoid, Inflammation, Focal        |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |       +                                                                  |   1        |
      Necrosis, Focal                      |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +        +           +                    +                              |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1|                             |            |
                             DAY ON TEST   | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1|                             |            |
                                           | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Atrophy                              | 3  3  3  3  1  2  3  2  3  3  3  2  3  3                                 |     14  2.6|
      Degeneration, Focal                  |                         1                                                |      1  1.0|
      Hypertrophy, Focal                   | 1  1  1  1        1     1  1  1        1                                 |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A                              |  14        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  +  +  A  +  +  A                              |  12        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active, Focal                    |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                   +                 +                                    |   2        |
      Ectasia                              |                   3                 3                                    |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Germinal Epithelium, Degeneration,   |                                                                          |            |
           Focal                           | 3        1     1     1        3                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
      Hyperplasia                          | 3        3                                                               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Inflammation, Chronic Active, Focal  |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1|                             |            |
                             DAY ON TEST   | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1|                             |            |
                                           | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                              |  14        |
      Hyperplasia                          |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Hematopoietic Cell Proliferation     | 2  2  1  1  1  2  1  1  1  2  2     2  1                                 |     13  1.5|
      Inflammation, Chronic Active, Focal  |                         1                                                |      1  1.0|
      Pigmentation                         |    1  1        1  1  1     1  1     1  1                                 |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  M  +  +  A                              |  12        |
      Atrophy, Diffuse                     | 3     3                                                                  |      2  3.0|
      Atrophy, Focal                       |                                     1                                    |      1  1.0|
      Hyperplasia                          |                         2     2                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Subcutaneous Tissue, Necrosis, Focal |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Inflammation, Chronic Active, Focal  | 2                                                                        |      1  2.0|
      Alveolus, Hemorrhage, Focal          |             1                                                            |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Focal, Lymphocyte               |                               1                                          |      1  1.0|
      Serosa, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active, Diffuse         |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1|                             |            |
                             DAY ON TEST   | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1|                             |            |
                                           | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    1 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +                              |  14        |
      Inflammation, Chronic Active, Focal  |                         4                                                |      1  4.0|
      Renal Tubule, Dilatation, Diffuse    |    1                                                                     |      1  1.0|
      Renal Tubule, Dilatation, Focal      |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    2 MG/KG                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |                                     +                                    |   1        |
      Muscularis, Periesophageal Tissue,   |                                                                          |            |
           Inflammation, Chronic Active,   |                                                                          |            |
           Diffuse                         |                                     4                                    |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |   2        |
      Fat, Necrosis, Focal                 |    4        4                                                            |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +  +  +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    2 MG/KG                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  14        |
      Atrophy                              | 3  3  4  3  2  3  4  3  4  4  4  3     3  3                              |     14  3.3|
      Hypertrophy, Focal                   | 1  1  1  1     1  1        1  1  1     1  1                              |     11  1.0|
      Subcapsular, Hyperplasia, Focal      |                      2                                                   |      1  2.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  A  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                                  +                                       |   1        |
      Ectasia                              |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |   1        |
      Dilatation                           | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Germinal Epithelium, Degeneration,   |                                                                          |            |
           Diffuse                         |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    2 MG/KG                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Germinal Epithelium, Degeneration,   |                                                                          |            |
           Focal                           |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 1  1  2  2  2  2  1  2  1  2  1  2  1  1  1                              |     15  1.5|
      Pigmentation                         | 1  1  1  1  1  1        1  1  1  1     1  1                              |     12  1.0|
      Lymphoid Follicle, Depletion Cellular|                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Atrophy, Diffuse                     |                                     3  2                                 |      2  2.5|
      Atrophy, Focal                       |             2  1     2                    1                              |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Focal           |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    2 MG/KG                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolus, Hemorrhage, Focal          |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Renal Tubule, Dilatation, Focal      |                               1                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         |                                        +                                 |   1        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1|                             |            |
                                           | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |       +                                                                  |   1        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic Active, Diffuse         |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  A  A  A  +  +  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  A  A  A  +  +  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  A  A  +  +  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
      Hepatocyte, Necrosis, Focal          |             1           1                                                |      2  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |                   A                                                      |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  A  A  A  +  +  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                +        +  +  +        +  +                              |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1|                             |            |
                                           | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
      Atrophy                              | 3  3     4  2        2  3        3  2  3  3                              |     10  2.8|
      Hypertrophy, Focal                   | 1  1     1  1        2  1        1  1  1  1                              |     10  1.1|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  +  +  A  +  +  A  M  I  I  +  +                              |   9        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  A  +  +  A  A  A  A  +  +                              |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Penis                                   |                               +                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +           +                    +        +                              |   4        |
      Ectasia                              | 3           3                    3        3                              |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  A  +  +  +  +                              |  13        |
      Hyperplasia                          |                         2              2  3                              |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +                              |  12        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1|                             |            |
                                           | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  A  A  A  M  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
      Congestion                           |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  1  2  2  2  2     2  3  2  2     2  2                                 |     12  1.9|
      Pigmentation                         | 1  1     1  1        1              1                                    |      6  1.0|
      Lymphoid Follicle, Depletion Cellular|                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  A  +  +  A  A  +  +  +  +                              |  10        |
      Atrophy, Diffuse                     |    3  3                                   4                              |      3  3.3|
      Atrophy, Focal                       |                                        2                                 |      1  2.0|
      Hyperplasia, Focal                   |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
      Arteriole, Artery, Inflammation,     |                                                                          |            |
           Chronic Active, Focal           |                            3  3                                          |      2  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1|                             |            |
                                           | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    4 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|                             |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Retina, Atrophy                      |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
      Bilateral, Cortex, Inflammation,     |                                                                          |            |
           Acute, Focal                    |                3                                                         |      1  3.0|
      Cortex, Inflammation, Acute, Focal   |                            2  3                                          |      2  2.5|
      Renal Tubule, Degeneration, Focal    | 1                       2                                                |      2  1.5|
      Renal Tubule, Dilatation, Diffuse    |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |       +                                                                  |   1        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic Active, Diffuse         |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Necrosis, Focal                      |                         1                                                |      1  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    1                 1                                                   |      2  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                      +                                                   |   1        |
      Acinus, Atrophy, Diffuse             |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                +  +     +     +                                          |   4        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Focal           |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
      Atrophy                              | 3  3     2  3  3     3  2  3  3     3  3  2                              |     12  2.8|
      Hypertrophy, Focal                   | 1  1     1  1  1     1     1  1     1  1  1                              |     11  1.0|
      Zona Reticularis, Vacuolization      |                                                                          |            |
          Cytoplasmic, Focal               |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  A  +  M  +  +  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
      Fat, Necrosis, Focal                 |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +                       +                                                |   2        |
      Ectasia                              | 3                       3                                                |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
      Bilateral, Dilatation                |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hyperplasia                          |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hematopoietic Cell Proliferation     | 1  1     1  1  1     2  3  2  2  1  2  1  2                              |     13  1.5|
      Pigmentation                         | 1  1     1  1  1     1     1  1     1  1  1                              |     11  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  I  +  A  +  +  +  +  +  +  +  +                              |  13        |
      Atrophy, Diffuse                     |       3                                                                  |      1  3.0|
      Atrophy, Focal                       |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Hyperkeratosis, Focal                |                1                                                         |      1  1.0|
      Dermis, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                2                                                         |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                2     1                                                   |      2  1.5|
      Subcutaneous Tissue, Necrosis, Focal | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Alveolus, Hemorrhage, Focal          |                   2                                                      |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96003-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:14    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   MICE:TGAC (FVB/N) HEMIZYGOUS MALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                             |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
          Active, Diffuse                  |       4                                                                  |      1  4.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                              |  14        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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