TDMS Study 96003-03 Pathology Tables
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
FINAL#1/MICE
Facility: BIORELIANCE
Chemical CAS #: 106-95-6
Lock Date: 10/18/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 008 VEHICLE CONTROL
Include 009 0.5 MG/KG
Include 010 1 MG/KG
Include 011 2 MG/KG
Include 012 4 MG/KG
Include 013 8 MG/KG
Include 001 VEHICLE CONTROL
Include 002 0.5 MG/KG
Include 003 1 MG/KG
Include 004 2 MG/KG
Include 005 4 MG/KG
Include 006 8 MG/KG
Page 1
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | |
| 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 2 |
Muscularis, Epithelium, Necrosis, | | |
Diffuse | 4 | 1 4.0|
Muscularis, Periesophageal Tissue, | | |
Inflammation, Chronic Active, | | |
Focal | 3 | 1 3.0|
Periesophageal Tissue, Foreign Body, | | |
Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | I + + + A + + + A + + + + + A | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Necrosis, Focal | 2 2 | 2 2.0|
Hepatocyte, Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 1 2 2 | 4 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | |
| 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic Active, | | |
Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + A + + + + + A | 13 |
Atrophy | 1 1 2 2 | 4 1.5|
Subcapsular, Hyperplasia, Focal | 1 1 | 2 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 4 3 4 3 | 6 3.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 2 1 1 2 1 1 | 6 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + A + + + + + A | 13 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + A + + M + + A | 11 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + + + + + A | 13 |
Follicle, Cyst, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + A + + + + + A | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | |
| 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Degeneration | 2 | 1 2.0|
Bilateral, Inflammation, Chronic | | |
Active, Diffuse | 4 | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + A + + + + + A | 13 |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 3 2 3 3 1 2 3 | 11 2.2|
Endometrium, Inflammation, Acute, | | |
Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + A | 14 |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + A | 13 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + A | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 2 2 3 1 2 3 3 2 2 2 2 2 | 13 2.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + A + + + + + A | 13 |
Atrophy, Diffuse | 2 4 4 4 3 | 5 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
Dilatation, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | |
| 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + | 14 |
Mediastinum, Inflammation, Acute, | | |
Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | M | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Bilateral, Inflammation, Acute, Focal| 4 | 1 4.0|
Bilateral, Nephropathy, Diffuse | 4 | 1 4.0|
Cortex, Pelvis, Inflammation, | | |
Chronic Active, Focal | 3 | 1 3.0|
Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Necrosis, Focal | 2 1 | 2 1.5|
Hepatocyte, Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 2 2 3 | 5 2.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Pancreas | + | 1 |
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + A + + + | 14 |
Atrophy | 2 1 2 1 2 2 | 6 1.7|
Subcapsular, Hyperplasia, Focal | 1 2 1 1 | 4 1.3|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 3 3 3 3 3 3 2 3 | 8 2.9|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A A + + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Angiectasis, Focal | 1 | 1 1.0|
Atrophy | 2 2 | 2 2.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Hydrometra | 1 | 1 1.0|
Inflammation, Acute, Diffuse | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 2 3 1 3 2 1 1 | 10 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + + + + | 14 |
Hematopoietic Cell Proliferation | 2 1 3 2 2 2 2 2 2 2 2 | 11 2.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Lymphoid Follicle, Depletion Cellular| 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + I + + + + A + + + + | 13 |
Atrophy, Diffuse | 3 3 3 | 3 3.0|
Atrophy, Focal | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Serosa, Mediastinum, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + | 14 |
Cortex, Inflammation, Acute, Focal | 3 | 1 3.0|
Renal Tubule, Degeneration, Focal | 1 | 1 1.0|
Renal Tubule, Dilatation, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | |
| 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + A + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + A + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + A A A | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + A A A | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + A A + | 12 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
Necrosis, Focal | 3 3 2 | 3 2.7|
Hepatocyte, Degeneration, Focal | 2 | 1 2.0|
Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 1 3 | 3 2.3|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + | 1 |
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 3 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | |
| 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + A + + + + + + + + A A A | 11 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + A + + + + + + + + + A A | 12 |
Atrophy | 2 1 2 1 2 2 2 1 2 | 9 1.7|
Subcapsular, Hyperplasia, Focal | 1 1 1 | 3 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 3 3 3 3 | 6 2.7|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 2 2 1 1 1 | 5 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + A A + | 12 |
Ectopic Thymus | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + A + + | 14 |
Atrophy | 2 3 | 2 2.5|
Cyst | 4 | 1 4.0|
Degeneration | 2 1 | 2 1.5|
Corpus Luteum, Inflammation, Chronic | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | |
| 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Active, Focal | 4 | 1 4.0|
Periovarian Tissue, Rete Ovarii, | | |
Inflammation, Acute, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + A A + | 13 |
Inflammation, Acute, Focal | 2 | 1 2.0|
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 2 3 2 1 1 3 2 | 8 1.9|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + A M | 12 |
Inflammation, Acute, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + + + + A A + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + A + | 14 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 2 2 3 4 2 3 2 3 2 2 2 4 3 2 | 15 2.5|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 | 10 1.1|
|__________________________________________________________________________|____________|
Thymus | + + + A + + + + + + + + A A + | 12 |
Atrophy, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Dermis, Fibrosis, Focal | 3 | 1 3.0|
Dermis, Subcutaneous Tissue, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | |
| 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Inflammation, Chronic Active, | | |
Diffuse | 2 | 1 2.0|
Epidermis, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolus, Hyperplasia, Focal, | | |
Histiocytic | 1 | 1 1.0|
Arteriole, Necrosis, Focal | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A | 14 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
Necrosis, Focal | 3 | 1 3.0|
Capsule, Inflammation, Acute, Focal | 1 | 1 1.0|
Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | |
| 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + + + + + + + + + A + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + + + + + + + A + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + + + + + + + + A + + | 12 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Necrosis, Focal | 2 3 | 2 2.5|
Hepatocyte, Necrosis, Focal | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 1 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + | 1 |
Atrium, Thrombosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + A A + + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | |
| 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Atrophy | 2 1 1 | 3 1.3|
Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 3 3 3 2 2 3 3 3 2 2 | 10 2.6|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + A A + + + + + + + + + M + + | 12 |
|__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + M + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + + | 14 |
Degeneration | 2 | 1 2.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + A + + | 14 |
Hydrometra | 3 3 | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | |
| 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 2 3 2 2 3 1 1 | 13 2.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 14 1.1|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + M + + | 13 |
Atrophy, Diffuse | 4 4 | 2 4.0|
Atrophy, Focal | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolus, Hemorrhage, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Papilla, Inflammation, Acute, Focal | 2 | 1 2.0|
Renal Tubule, Dilatation, Focal | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + A + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + A + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + A + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + A + + + + | 13 |
Serosa, Inflammation, Acute, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + A + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + A + + + + | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + A + | 14 |
Infiltration Cellular, Diffuse, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute, Focal | 3 | 1 3.0|
Necrosis, Chronic Active, Focal | 3 | 1 3.0|
Necrosis, Focal | 2 | 1 2.0|
Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 2 4 | 4 2.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 | 2 1.5|
Serosa, Inflammation, Acute, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + | 3 |
Inflammation, Acute, Diffuse | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + | 14 |
Muscularis, Serosa, Inflammation, | | |
Acute, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + + + + + A + + + + + A + | 13 |
Serosa, Inflammation, Acute, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + A + A + + + A + | 12 |
Atrophy | 1 1 1 1 2 2 2 2 1 2 2 | 11 1.5|
Subcapsular, Hyperplasia, Focal | 1 1 2 1 1 | 5 1.2|
Zona Reticularis, Hyperplasia, | | |
Diffuse | 4 | 1 4.0|
Zona Reticularis, Infiltration | | |
Cellular, Focal, Lymphocyte | 1 | 1 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 3 2 4 4 2 4 2 | 9 2.8|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + A + A + + + A + | 12 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + A + + A + | 12 |
Ectopic Thymus | 1 | 1 1.0|
Follicle, Cyst, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + M + + + A + | 13 |
Atrophy | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Degeneration | 2 | 1 2.0|
Inflammation, Acute, Diffuse | 4 | 1 4.0|
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
Bilateral, Periovarian Tissue, Cyst | 2 | 1 2.0|
Periovarian Tissue, Rete Ovarii, | | |
Inflammation, Acute, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Oviduct | A | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + A + + A + + A + | 12 |
Atrophy | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 4 3 2 2 3 2 2 1 2 | 10 2.2|
Serosa, Inflammation, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Iliac, Hyperplasia | 3 | 1 3.0|
Renal, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + A + + A + + A + | 12 |
Hyperplasia | 3 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + + A + + A + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + A + + A + + A + | 12 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + A + | 13 |
Hematopoietic Cell Proliferation | 4 2 3 2 3 2 3 2 2 2 1 2 | 12 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Capsule, Inflammation, Acute, Focal | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + A + A A + + A + | 11 |
Atrophy, Focal | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + A + | 14 |
Alveolus, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Mediastinum, Inflammation, Acute, | | |
Focal | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + A + + + + + A + | 13 |
Inflammation, Chronic Active, Focal | 4 | 1 4.0|
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
| 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Diffuse, | | |
Polymorphonuclear | 4 | 1 4.0|
Necrosis, Focal | 1 1 | 2 1.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 | 1 1.0|
Hepatocyte, Necrosis, Focal | 1 1 1 1 | 4 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 2 | 3 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 1 1 | 3 1.0|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | 1 1 | 2 1.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
| 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 1 1 1 | 4 1.3|
Mineralization, Focal | 1 | 1 1.0|
Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Diffuse | 3 3 2 3 3 2 2 3 2 3 2 3 | 12 2.6|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst, Focal | 3 | 1 3.0|
Degeneration | 1 | 1 1.0|
Inflammation, Diffuse | 4 | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Acute, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 2 4 3 2 1 2 1 2 2 2 2 2 3 | 13 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
| 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 3 | 2 2.5|
Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + I | 14 |
Inflammation, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 4 2 2 1 1 2 2 1 2 2 2 2 2 2 | 14 1.9|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy, Diffuse | 4 | 1 4.0|
Atrophy, Focal | 1 1 1 2 3 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolus, Hemorrhage, Focal | 1 | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
| 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
Bilateral, Inflammation, Acute, Focal| 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + A + + + + + + + | 14 |
Hepatocyte, Necrosis, Focal | 1 1 | 2 1.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 1 | 1 1.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 2 3 3 3 3 3 2 4 3 3 3 3 3 3 | 15 2.9|
Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 2 2 | 13 1.2|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Penis | + + + | 3 |
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Ectasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration, | | |
Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 | 14 1.1|
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy, Diffuse | 3 2 3 | 3 2.7|
Atrophy, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Retina, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | |
| 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 4 | 1 4.0|
Serosa, Inflammation, Chronic Active,| | |
Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | |
| 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Tooth | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + A + + + | 14 |
Atrophy | 3 3 3 3 3 3 1 3 3 3 3 3 3 | 13 2.8|
Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + + A + + + | 13 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Ectasia | 3 | 1 3.0|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | |
| 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + A + + + + A + + + | 13 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + A + + + + A + + + | 13 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + + + | 14 |
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 2 1 1 1 2 1 1 | 14 1.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + I + + A + + + | 13 |
Atrophy, Diffuse | 4 4 3 | 3 3.7|
Atrophy, Focal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | |
| 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Arteriole, Capillary, Perivascular, | | |
Inflammation, Acute | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Focal, Lymphocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + | 14 |
Inflammation, Acute, Focal | 3 | 1 3.0|
Capsule, Cortex, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | |
DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | |
| 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + A | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + A + + A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + A + + A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + A + + A | 12 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + A + + + | 14 |
Hepatocyte, Necrosis, Focal | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 1 2 | 2 1.5|
Sinusoid, Inflammation, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + A | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | |
DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | |
| 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Atrophy | 3 3 3 3 1 2 3 2 3 3 3 2 3 3 | 14 2.6|
Degeneration, Focal | 1 | 1 1.0|
Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + A | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + + + A + + A | 12 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mediastinum, Inflammation, Chronic | | |
Active, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Ectasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration, | | |
Focal | 3 1 1 1 3 | 5 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + | 14 |
Hyperplasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | |
DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | |
| 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + | 14 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + + + | 14 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 2 1 1 1 2 2 2 1 | 13 1.5|
Inflammation, Chronic Active, Focal | 1 | 1 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + M + + A | 12 |
Atrophy, Diffuse | 3 3 | 2 3.0|
Atrophy, Focal | 1 | 1 1.0|
Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Subcutaneous Tissue, Necrosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + A + + + | 14 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Alveolus, Hemorrhage, Focal | 1 | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Focal, Lymphocyte | 1 | 1 1.0|
Serosa, Mediastinum, Inflammation, | | |
Chronic Active, Diffuse | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | |
DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | |
| 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + | 14 |
Inflammation, Chronic Active, Focal | 4 | 1 4.0|
Renal Tubule, Dilatation, Diffuse | 1 | 1 1.0|
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Muscularis, Periesophageal Tissue, | | |
Inflammation, Chronic Active, | | |
Diffuse | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + A + + | 14 |
Atrophy | 3 3 4 3 2 3 4 3 4 4 4 3 3 3 | 14 3.3|
Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Subcapsular, Hyperplasia, Focal | 2 | 1 2.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + A + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Ectasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration, | | |
Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Germinal Epithelium, Degeneration, | | |
Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 2 1 2 1 2 1 1 1 | 15 1.5|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy, Diffuse | 3 2 | 2 2.5|
Atrophy, Focal | 2 1 2 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolus, Hemorrhage, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | |
| 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active, Diffuse | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + A A + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + A A + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + A A A + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + A A A + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A A A + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A A + + + + | 12 |
|__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + | 14 |
Hepatocyte, Necrosis, Focal | 1 1 | 2 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | A | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + A A A + + + | 11 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | |
| 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + + A A + + + + | 12 |
Atrophy | 3 3 4 2 2 3 3 2 3 3 | 10 2.8|
Hypertrophy, Focal | 1 1 1 1 2 1 1 1 1 1 | 10 1.1|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + A + + A A + + + + | 12 |
|__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + A + + A M I I + + | 9 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + A + + A A A A + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + | 4 |
Ectasia | 3 3 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + A + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + A + + + + | 13 |
Hyperplasia | 2 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + + A A + + + + | 12 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | |
| 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mediastinal | + + + + + + M + + A A A M + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + | 14 |
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 2 2 2 2 2 3 2 2 2 2 | 12 1.9|
Pigmentation | 1 1 1 1 1 1 | 6 1.0|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + M A + + A A + + + + | 10 |
Atrophy, Diffuse | 3 3 4 | 3 3.3|
Atrophy, Focal | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + A + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + A + + + + + + + + | 14 |
Arteriole, Artery, Inflammation, | | |
Chronic Active, Focal | 3 3 | 2 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | |
| 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + | 14 |
Bilateral, Cortex, Inflammation, | | |
Acute, Focal | 3 | 1 3.0|
Cortex, Inflammation, Acute, Focal | 2 3 | 2 2.5|
Renal Tubule, Degeneration, Focal | 1 2 | 2 1.5|
Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 1 | 2 1.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + | 1 |
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Peridontal Tissue, Inflammation, | | |
Chronic Active, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + + + + + + + + | 14 |
Atrophy | 3 3 2 3 3 3 2 3 3 3 3 2 | 12 2.8|
Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + M + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Fat, Necrosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Ectasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Bilateral, Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + A + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 3 2 2 1 2 1 2 | 13 1.5|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + I + A + + + + + + + + | 13 |
Atrophy, Diffuse | 3 | 1 3.0|
Atrophy, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis, Focal | 1 | 1 1.0|
Dermis, Inflammation, Chronic Active,| | |
Focal | 2 | 1 2.0|
Epidermis, Hyperplasia, Focal | 2 1 | 2 1.5|
Subcutaneous Tissue, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolus, Hemorrhage, Focal | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01
Route: GAVAGE Time: 09:19:14
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | |
| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Active, Diffuse | 4 | 1 4.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
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---------- END OF REPORT ----------
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