TDMS Study 96003-04 Pathology Tables
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
FINAL#1/MICE
Facility: BIORELIANCE
Chemical CAS #: 106-95-6
Lock Date: 10/18/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 14
Animals Examined Microscopically 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15)
Hepatocyte, Necrosis, Focal 2 (13%) 2 (13%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 2 (13%) 2 (13%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 2 (13%) 3 (20%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (7%)
Kupffer Cell, Hyperplasia, Diffuse 1 (7%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (15) (15)
Atrophy 2 (13%) 2 (13%)
Subcapsular, Hyperplasia, Focal 8 (53%) 9 (60%)
Zona Reticularis, Vacuolization Cytoplasmic,
Diffuse 12 (80%) 13 (87%)
Zona Reticularis, Vacuolization Cytoplasmic,
Focal 2 (13%) 2 (13%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15)
Hemorrhage, Focal 2 (13%)
Inflammation, Acute, Focal 1 (7%)
Inflammation, Chronic Active, Focal 1 (7%)
Uterus (15) (15)
Hydrometra 2 (13%) 1 (7%)
Endometrium, Hyperplasia, Cystic 14 (93%) 15 (100%)
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HEMATOPOIETIC SYSTEM
Spleen (15) (15)
Hematopoietic Cell Proliferation 15 (100%) 15 (100%)
Pigmentation 15 (100%) 14 (93%)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (15) (14)
Atrophy, Focal 4 (27%) 3 (21%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Alveolar Epithelium, Hyperplasia, Focal 1 (7%)
Alveolus, Hemorrhage, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15)
Renal Tubule, Dilatation, Focal 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15
Early Deaths
Dosing Accident 1
Survivors
Terminal Sacrifice 15 14
Animals Examined Microscopically 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Epithelium, Hyperplasia, Diffuse 1 (100%)
Muscularis, Periesophageal Tissue,
Inflammation, Chronic Active, Focal 1 (100%)
Liver (15) (15)
Tension Lipidosis 1 (7%)
Hepatocyte, Necrosis, Focal 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 3 (20%) 2 (13%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic, Focal 1 (7%)
Serosa, Mineralization, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (14)
Atrophy 15 (100%) 14 (100%)
Hypertrophy, Focal 13 (87%) 14 (100%)
Subcapsular, Hyperplasia, Focal 1 (7%)
Thyroid Gland (15) (15)
Ectopic Thymus 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (2) (2)
Ectasia 2 (100%) 2 (100%)
Infiltration Cellular, Focal, Lymphocyte 1 (50%)
Testes (15) (15)
Germinal Epithelium, Degeneration, Focal 2 (13%) 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mediastinal (14) (15)
Hyperplasia 1 (7%)
Spleen (15) (15)
Hematopoietic Cell Proliferation 15 (100%) 13 (87%)
Pigmentation 11 (73%) 11 (73%)
Lymphoid Follicle, Atrophy 1 (7%)
Thymus (15) (15)
Atrophy, Diffuse 1 (7%)
Atrophy, Focal 2 (13%) 3 (20%)
Hyperplasia, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15)
Subcutaneous Tissue, Inflammation, Chronic
Active, Focal 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:45:38
____________________________________________________________________________________________________________________________________
MICE:FVB/N MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Hemorrhage, Focal 1 (7%)
Alveolar Epithelium, Hyperplasia, Focal 1 (7%) 1 (7%)
Mediastinum, Inflammation, Acute, Focal 1 (7%)
Perivascular, Infiltration Cellular, Focal,
Lymphocyte 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15)
Renal Tubule, Degeneration, Focal 1 (7%)
Renal Tubule, Dilatation, Diffuse 1 (7%)
Renal Tubule, Dilatation, Focal 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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