TDMS Study 96003-05 Pathology Tables
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
FINAL#1/MICE
Facility: BIORELIANCE
Chemical CAS #: 106-95-6
Lock Date: 10/18/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Moribund Sacrifice 2 1 2 1
Natural Death 1 1
Survivors
Terminal Sacrifice 13 14 13 14 15 13
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (14) (15) (15)
Lymphoma Malignant 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (14) (15) (15)
Lymphoma Malignant 1 (7%)
Adrenal Medulla (15) (15) (15) (14) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Sarcoma 1 (100%)
Abdominal, Sarcoma 1 (100%)
Pelvic, Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Lymphoma Malignant 1 (100%)
Lymph Node, Mandibular (15) (14) (15) (14) (15) (13)
Lymphoma Malignant 1 (7%)
Lymph Node, Mesenteric (15) (14) (15) (12) (15) (15)
Lymphoma Malignant 1 (7%)
Lymph Node, Mediastinal (15) (14) (15) (14) (15) (14)
Lymphoma Malignant 1 (7%) 1 (7%)
Spleen (15) (15) (15) (14) (15) (15)
Lymphoma Malignant 1 (7%) 1 (7%) 1 (7%)
Thymus (14) (14) (14) (14) (15) (14)
Lymphoma Malignant 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (14) (15) (15)
Subcutaneous Tissue, Osteosarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (1) (1)
Osteosarcoma 1 (100%)
Mandible, Osteosarcoma 1 (100%)
Vertebra, Osteosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%)
Osteosarcoma, Metastatic, Skin 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Lymphoma Malignant 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 4 2 1 1 2
Total Primary Neoplasms 4 2 1 1 2
Total Animals with Benign Neoplasms
Total Benign Neoplasms
Total Animals with Malignant Neoplasms 4 2 1 1 2
Total Malignant Neoplasms 4 2 1 1 2
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 14 15 15 13 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Stomach, Forestomach (15) (15) (15) (15) (14) (15)
Squamous Cell Papilloma 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 7
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:50:46
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 2 1
Total Primary Neoplasms 1 2 1
Total Animals with Benign Neoplasms 2 1
Total Benign Neoplasms 2 1
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 8
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------