TDMS Study 96003-05 Pathology Tables
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
FINAL#1/MICE
Facility: BIORELIANCE
Chemical CAS #: 106-95-6
Lock Date: 10/18/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Moribund Sacrifice 2 1 2 1
Natural Death 1 1
Survivors
Terminal Sacrifice 13 14 13 14 15 13
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (15) (15) (15) (14) (15) (14)
Polyp Inflammatory, Focal 1 (7%)
Liver (15) (15) (15) (14) (15) (15)
Infiltration Cellular, Focal, Lymphocyte 3 (20%) 2 (13%) 4 (27%) 6 (43%) 7 (47%) 2 (13%)
Necrosis, Focal 1 (7%)
Tension Lipidosis 1 (7%)
Hepatocyte, Necrosis, Focal 1 (7%) 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%) 2 (13%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 8 (53%) 8 (53%) 8 (53%) 6 (43%) 3 (20%) 5 (33%)
Salivary Glands (1)
Infiltration Cellular, Focal, Lymphocyte 1 (100%)
Stomach, Forestomach (15) (15) (15) (14) (15) (14)
Hyperkeratosis, Focal 1 (7%)
Epithelium, Hyperplasia, Focal 1 (7%)
Muscularis, Inflammation, Acute, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (14) (15) (15)
Subcapsular, Hyperplasia, Focal 13 (87%) 14 (93%) 15 (100%) 12 (86%) 12 (80%) 13 (87%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (14) (14) (15) (13) (15) (13)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst, Focal 1 (7%)
Thyroid Gland (14) (15) (15) (14) (14) (15)
Ectopic Thymus 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (14) (15) (14)
Cyst 1 (7%)
Degeneration 1 (7%)
Uterus (15) (15) (15) (14) (15) (14)
Inflammation, Acute 1 (7%)
Thrombosis, Focal 1 (7%)
Endometrium, Hyperplasia, Cystic 13 (87%) 13 (87%) 14 (93%) 13 (93%) 14 (93%) 14 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Hyperplasia 1 (100%)
Lymph Node, Mandibular (15) (14) (15) (14) (15) (13)
Hyperplasia 1 (7%) 1 (7%) 1 (7%)
Lymph Node, Mesenteric (15) (14) (15) (12) (15) (15)
Hyperplasia 1 (7%)
Lymph Node, Mediastinal (15) (14) (15) (14) (15) (14)
Hyperplasia 1 (7%)
Spleen (15) (15) (15) (14) (15) (15)
Hematopoietic Cell Proliferation 8 (53%) 6 (40%) 7 (47%) 10 (71%) 9 (60%) 7 (47%)
Hyperplasia, Lymphoid 1 (7%) 1 (7%)
Pigmentation 4 (27%) 8 (53%) 4 (27%) 2 (14%) 2 (13%) 2 (13%)
Lymphoid Follicle, Depletion Cellular,
Diffuse 1 (7%) 1 (7%)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (14) (14) (14) (14) (15) (14)
Atrophy, Diffuse 1 (7%) 2 (13%) 1 (7%)
Atrophy, Focal 1 (7%) 2 (14%)
Hyperplasia, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (14) (15) (15)
Epidermis, Hyperplasia, Diffuse 1 (7%)
Epidermis, Hyperplasia, Focal 2 (13%) 1 (7%)
Subcutaneous Tissue, Edema, Diffuse 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (1) (1)
Metatarsal, Fracture 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar Epithelium, Hyperplasia, Focal 1 (7%)
Alveolus, Inflammation, Chronic Active, Focal 1 (7%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (14) (15) (15)
Pelvis, Infiltration Cellular, Focal,
Lymphocyte 1 (7%) 2 (13%)
Renal Tubule, Dilatation, Focal 4 (27%) 3 (20%) 1 (7%) 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 14 15 15 13 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (14) (15)
Basophilic Focus 1 (7%)
Infiltration Cellular, Focal, Lymphocyte 1 (7%) 2 (13%)
Tension Lipidosis 1 (7%)
Hepatocyte, Necrosis, Focal 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 5 (33%) 7 (47%) 11 (73%) 7 (47%) 8 (57%) 6 (40%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%) 1 (7%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 4 (27%) 2 (13%) 2 (13%) 1 (7%) 2 (14%) 2 (13%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 3 (20%) 1 (7%) 2 (13%) 2 (14%) 3 (20%)
Salivary Glands (1)
Infiltration Cellular, Focal, Lymphocyte 1 (100%)
Stomach, Forestomach (15) (15) (15) (15) (14) (15)
Epithelium, Ulcer, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15) (14) (15)
Atrophy 1 (7%) 1 (7%)
Degeneration, Diffuse 1 (7%) 1 (7%)
Hypertrophy, Focal 1 (7%)
Subcapsular, Hyperplasia, Focal 1 (7%) 1 (7%) 1 (7%) 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Medulla (15) (15) (15) (15) (14) (15)
Degeneration, Diffuse 1 (7%)
Thyroid Gland (15) (15) (14) (15) (14) (15)
Follicular Cell, Hyperplasia, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abdominal, Fat, Necrosis, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15) (14) (15)
Granuloma Sperm, Focal 1 (7%)
Necrosis, Focal 1 (7%)
Testes (15) (15) (15) (15) (14) (15)
Degeneration, Diffuse 1 (7%)
Inflammation, Focal, Granulomatous 1 (7%)
Mineralization, Focal 1 (7%)
Germinal Epithelium, Degeneration, Diffuse 1 (7%)
Germinal Epithelium, Degeneration, Focal 1 (7%) 2 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (13) (14) (12) (14) (12) (14)
Hyperplasia 1 (8%)
Spleen (15) (15) (15) (15) (14) (15)
Hematopoietic Cell Proliferation 1 (7%) 2 (13%) 2 (13%) 2 (14%) 3 (20%)
Pigmentation 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (14) (15)
Epidermis, Control, Hyperplasia, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:49:05
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar Epithelium, Inflammation, Chronic,
Focal 1 (7%)
Perivascular, Alveolus, Inflammation,
Chronic Active, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (14) (15)
Cyst 1 (7%)
Infiltration Cellular, Focal, Lymphocyte 1 (7%)
Pelvis, Infiltration Cellular, Focal,
Lymphocyte 2 (13%) 2 (13%) 2 (14%) 1 (7%)
Renal Tubule, Dilatation, Diffuse 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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