TDMS Study 96003-06 Pathology Tables
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 FINAL#1/MICE Facility: BIORELIANCE Chemical CAS #: 106-95-6 Lock Date: 10/18/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 Early Deaths Moribund Sacrifice 2 Natural Death 1 Survivors Terminal Sacrifice 15 12 Animals Examined Microscopically 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Jejunum (15) (15) Degeneration, Focal 1 (7%) Liver (15) (15) Infiltration Cellular, Focal, Lymphocyte 2 (13%) 6 (40%) Hepatocyte, Periportal, Vacuolization Cytoplasmic 9 (60%) 6 (40%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (14) Subcapsular, Hyperplasia, Focal 14 (93%) 10 (71%) Thyroid Gland (15) (15) Ectopic Thymus 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Uterus (15) (15) Endometrium, Hyperplasia, Cystic 13 (87%) 12 (80%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Hyperplasia 1 (100%) Inguinal, Hyperplasia 1 (100%) Lymph Node, Mandibular (15) (15) Hyperplasia 1 (7%) 3 (20%) Lymph Node, Mediastinal (15) (11) Hyperplasia 1 (9%) Spleen (15) (14) Hematopoietic Cell Proliferation 9 (60%) 12 (86%) Pigmentation 7 (47%) 4 (29%) Thymus (15) (14) Atrophy, Diffuse 2 (14%) Atrophy, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) Epidermis, Ulcer, Chronic Active, Diffuse 1 (7%) Epidermis, Control, Inflammation, Chronic Active, Diffuse 1 (7%) Epidermis, Control, Ulcer, Chronic Active, Diffuse 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) Alveolus, Inflammation, Chronic Active, Focal 1 (7%) Perivascular, Infiltration Cellular, Lymphocyte 2 (13%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) Mineralization, Focal 1 (7%) Pelvis, Infiltration Cellular, Focal, Lymphocyte 2 (13%) Renal Tubule, Dilatation, Focal 2 (13%) 4 (27%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 Early Deaths Moribund Sacrifice 1 Survivors Terminal Sacrifice 14 15 Animals Examined Microscopically 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) Infiltration Cellular, Focal, Lymphocyte 1 (7%) Hepatocyte, Vacuolization Cytoplasmic, Diffuse 4 (27%) 9 (60%) Hepatocyte, Periportal, Vacuolization Cytoplasmic 2 (13%) 1 (7%) Hepatocyte, Centrilobular, Vacuolization Cytoplasmic 2 (13%) Stomach, Forestomach (15) (15) Serosa, Necrosis, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) Atrophy 4 (27%) 3 (20%) Hypertrophy, Focal 1 (7%) Subcapsular, Hyperplasia, Focal 3 (20%) Thyroid Gland (14) (15) Follicle, Inflammation, Acute, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Testes (15) (15) Germinal Epithelium, Degeneration, Diffuse 2 (13%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (15) (15) Hematopoietic Cell Proliferation 4 (27%) 1 (7%) Thymus (15) (15) Atrophy, Diffuse 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) Perivascular, Infiltration Cellular, Lymphocyte 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:52:18 ____________________________________________________________________________________________________________________________________ C57BL/6 MICE MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Kidney (15) (15) Pelvis, Infiltration Cellular, Focal, Lymphocyte 3 (20%) 2 (13%) Renal Tubule, Dilatation, Diffuse 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------