TDMS Study 96003-06 Pathology Tables
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
FINAL#1/MICE
Facility: BIORELIANCE
Chemical CAS #: 106-95-6
Lock Date: 10/18/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15
Early Deaths
Moribund Sacrifice 2
Natural Death 1
Survivors
Terminal Sacrifice 15 12
Animals Examined Microscopically 15 15
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (15) (15)
Degeneration, Focal 1 (7%)
Liver (15) (15)
Infiltration Cellular, Focal, Lymphocyte 2 (13%) 6 (40%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 9 (60%) 6 (40%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (15) (14)
Subcapsular, Hyperplasia, Focal 14 (93%) 10 (71%)
Thyroid Gland (15) (15)
Ectopic Thymus 1 (7%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Uterus (15) (15)
Endometrium, Hyperplasia, Cystic 13 (87%) 12 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Hyperplasia 1 (100%)
Inguinal, Hyperplasia 1 (100%)
Lymph Node, Mandibular (15) (15)
Hyperplasia 1 (7%) 3 (20%)
Lymph Node, Mediastinal (15) (11)
Hyperplasia 1 (9%)
Spleen (15) (14)
Hematopoietic Cell Proliferation 9 (60%) 12 (86%)
Pigmentation 7 (47%) 4 (29%)
Thymus (15) (14)
Atrophy, Diffuse 2 (14%)
Atrophy, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15)
Epidermis, Ulcer, Chronic Active, Diffuse 1 (7%)
Epidermis, Control, Inflammation, Chronic
Active, Diffuse 1 (7%)
Epidermis, Control, Ulcer, Chronic Active,
Diffuse 1 (7%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Alveolus, Inflammation, Chronic Active, Focal 1 (7%)
Perivascular, Infiltration Cellular,
Lymphocyte 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE FEMALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15)
Mineralization, Focal 1 (7%)
Pelvis, Infiltration Cellular, Focal,
Lymphocyte 2 (13%)
Renal Tubule, Dilatation, Focal 2 (13%) 4 (27%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 14 15
Animals Examined Microscopically 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15)
Infiltration Cellular, Focal, Lymphocyte 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 4 (27%) 9 (60%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 2 (13%) 1 (7%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 2 (13%)
Stomach, Forestomach (15) (15)
Serosa, Necrosis, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15)
Atrophy 4 (27%) 3 (20%)
Hypertrophy, Focal 1 (7%)
Subcapsular, Hyperplasia, Focal 3 (20%)
Thyroid Gland (14) (15)
Follicle, Inflammation, Acute, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (15) (15)
Germinal Epithelium, Degeneration, Diffuse 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15)
Hematopoietic Cell Proliferation 4 (27%) 1 (7%)
Thymus (15) (15)
Atrophy, Diffuse 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96003-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01
Route: GAVAGE Time: 13:52:18
____________________________________________________________________________________________________________________________________
C57BL/6 MICE MALE VEHICLE 8 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Kidney (15) (15)
Pelvis, Infiltration Cellular, Focal,
Lymphocyte 3 (20%) 2 (13%)
Renal Tubule, Dilatation, Diffuse 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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