TDMS Study 20114-01 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst SODIUM DICHROMATE DIHYDRATE (VI) DATE: 07/27/04
EXPERIMENT: 20114 TEST: 01 TIME: 09:30:17
PAGE: 1
TEST TYPE: SUBCHRON 90-DAY ROUTE: DOSED WATER NTP: C20114
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE SODIUM DICHROMATE DIHYDRATE (VI) DATE: 07/27/04
EXPERIMENT: 20114 TEST: 01 TIME: 9:34:10
TEST TYPE: SUBCHRONIC (90-DAY) ROUTE: DOSED WATER NTP: C20114
CONT: N01-ES-15463 CAS: 7789-12-0
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5MG/L 125MG/L 250MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 15.9 101.0 15.6 100.1 0.98 9.7 14.7 100.7 0.92 18.2 13.8 101.2 0.87 34.0
2 17.5 135.8 15.6 136.0 0.89 7.2 15.1 132.6 0.86 14.2 13.3 128.0 0.76 26.0
3 17.4 169.4 17.7 167.4 1.02 6.6 16.1 164.0 0.93 12.3 14.4 162.6 0.83 22.2
4 18.3 205.0 16.8 203.6 0.92 5.2 15.8 198.7 0.86 9.9 14.9 194.5 0.81 19.1
5 16.8 226.6 16.9 217.6 1.01 4.9 16.1 219.8 0.96 9.2 14.9 220.2 0.89 16.9
6 17.1 240.8 15.9 244.9 0.93 4.0 14.6 247.3 0.85 7.4 14.7 244.3 0.86 15.1
7 17.9 260.7 17.9 256.8 1.00 4.3 16.0 255.8 0.89 7.8 14.6 260.6 0.82 14.0
8 16.5 279.8 15.2 278.5 0.92 3.4 14.7 281.7 0.89 6.5 14.1 275.4 0.85 12.8
9 14.9 263.1 15.9 280.1 1.07 3.6 14.0 279.3 0.94 6.2 13.9 278.6 0.93 12.5
10 19.0 281.0 16.3 289.8 0.86 3.5 13.7 293.6 0.72 5.8 14.1 289.6 0.74 12.2
11 16.7 290.7 15.1 288.7 0.90 3.3 13.8 305.8 0.83 5.7 13.5 295.1 0.81 11.4
12 15.1 307.2 15.8 309.0 1.05 3.2 14.8 313.1 0.98 5.9 13.6 310.3 0.90 11.0
13 14.8 316.1 12.0 296.3 0.81 2.5 14.0 324.0 0.95 5.4 12.7 323.0 0.86 9.8
1 TO 13 WEEKS
----------------
MEAN 16.8 236.7 15.9 236.1 0.95 4.7 14.9 239.7 0.89 8.8 14.0 237.2 0.84 16.7
SD(D) 1.3 1.5 0.08 2.0 0.9 0.07 3.9 0.7 0.05 7.0
CV(E) 7.8 9.2 8.0 42.9 6.0 7.7 44.4 4.7 6.4 42.1
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
=============================================================================
500MG/L 1000 MG/L
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
1 11.9 101.0 0.75 58.7 9.0 101.2 0.57 88.4
2 12.2 128.7 0.70 47.6 11.0 122.4 0.63 89.9
3 13.6 159.9 0.78 42.5 12.1 152.8 0.70 79.3
4 14.0 188.9 0.77 37.1 13.6 160.3 0.74 84.8
5 14.2 214.7 0.85 33.1 12.8 192.5 0.76 66.7
6 13.5 235.6 0.79 28.7 12.2 217.8 0.71 56.2
7 13.4 250.0 0.75 26.9 12.9 232.2 0.72 55.5
8 13.2 267.1 0.80 24.7 12.2 248.0 0.74 49.1
9 13.3 270.2 0.89 24.6 11.6 252.7 0.78 45.9
10 12.6 284.8 0.66 22.1 13.6 265.5 0.72 51.3
11 12.2 295.3 0.73 20.7 10.8 279.3 0.65 38.8
12 12.6 294.6 0.83 21.3 10.8 281.9 0.72 38.2
13 13.4 300.9 0.91 22.2 11.6 282.6 0.78 40.9
1 TO 13 WEEKS
----------------
MEAN 13.1 230.1 0.78 31.6 11.9 214.6 0.71 60.4
SD(D) 0.7 0.07 11.8 1.3 0.06 19.3
CV(E) 5.5 9.1 37.4 10.9 8.8 31.9
=============================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5MG/L 125MG/L 250MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 14.1 89.1 14.0 90.5 0.99 9.6 13.0 88.6 0.92 18.3 11.7 89.7 0.83 32.6
2 14.3 118.2 15.0 121.8 1.05 7.7 13.3 117.9 0.93 14.1 11.6 117.6 0.81 24.8
3 14.7 135.7 14.9 141.5 1.01 6.6 13.5 136.3 0.92 12.4 11.7 133.5 0.80 22.0
4 16.1 148.6 14.0 154.9 0.87 5.7 12.5 149.1 0.78 10.5 11.7 147.2 0.73 19.9
5 13.5 157.4 13.8 165.1 1.02 5.2 12.5 158.9 0.93 9.9 11.0 155.8 0.81 17.6
6 12.7 163.7 13.1 173.0 1.03 4.8 11.7 168.0 0.92 8.7 10.6 165.0 0.83 16.1
7 13.6 169.2 13.4 180.2 0.99 4.7 12.5 176.1 0.92 8.9 11.0 173.7 0.81 15.8
8 13.0 170.8 12.7 181.7 0.98 4.4 11.4 176.7 0.88 8.0 11.0 175.4 0.85 15.7
9 13.9 180.7 13.5 189.4 0.97 4.4 11.9 183.5 0.86 8.1 11.2 182.2 0.81 15.4
10 13.0 185.9 12.6 192.0 0.97 4.1 11.0 186.6 0.85 7.4 10.1 186.6 0.78 13.5
11 11.7 188.2 12.6 196.3 1.08 4.0 11.6 182.2 0.99 8.0 9.8 189.7 0.84 12.9
12 11.2 188.6 11.9 199.3 1.06 3.7 10.6 189.8 0.95 7.0 9.7 189.7 0.87 12.8
13 11.2 189.8 12.7 205.0 1.13 3.9 10.9 195.2 0.97 7.0 9.4 192.9 0.84 12.2
1 TO 13 WEEKS
----------------
MEAN 13.3 160.5 13.4 168.5 1.01 5.3 12.0 162.2 0.91 9.9 10.8 161.5 0.81 17.8
SD(D) 1.4 0.9 0.06 1.7 0.9 0.06 3.3 0.8 0.04 5.8
CV(E) 10.6 6.9 6.4 32.9 7.6 6.3 33.4 7.6 4.3 32.7
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
=============================================================================
500MG/L 1000 MG/L
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
1 10.3 89.2 0.73 57.5 8.3 88.0 0.59 93.7
2 10.5 115.7 0.73 45.4 8.9 101.9 0.62 87.6
3 10.6 131.0 0.72 40.6 9.0 122.4 0.61 73.6
4 10.6 144.3 0.66 36.7 9.1 135.6 0.57 67.2
5 10.4 153.9 0.77 33.9 9.1 145.2 0.67 62.7
6 9.7 162.5 0.76 29.9 8.9 152.3 0.70 58.3
7 10.3 169.9 0.76 30.2 9.4 160.6 0.69 58.8
8 9.6 171.1 0.74 28.2 8.8 162.4 0.68 54.2
9 10.0 178.5 0.72 28.1 9.4 168.5 0.68 55.8
10 9.2 180.8 0.71 25.5 8.3 170.5 0.64 48.7
11 9.3 184.8 0.79 25.1 8.2 174.9 0.70 47.0
12 9.1 187.1 0.81 24.3 8.0 176.3 0.71 45.5
13 9.1 189.0 0.81 24.2 8.1 179.1 0.72 45.0
1 TO 13 WEEKS
----------------
MEAN 9.9 158.3 0.75 33.0 8.7 149.1 0.66 61.4
SD(D) 0.6 0.04 9.8 0.5 0.05 15.6
CV(E) 5.9 5.9 29.8 5.7 7.6 25.3
=============================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5MG/L 125MG/L 250MG/L 500MG/L
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
===================================================================================================================================
B 101.0 10 100.1 10 100.7 10 101.2 10 101.0 10
1 15.9 676 101.0 10 15.6 676 100.1 10 14.7 678 100.7 10 13.8 678 101.2 10 11.9 678 101.0 10
2 17.5 1192 135.8 10 15.6 1698 136.0 10 15.1 1700 132.6 10 13.3 1700 128.0 10 12.2 1698 128.7 10
3 17.4 1682 169.4 10 17.7 1664 167.4 10 16.1 1664 164.0 10 14.4 1664 162.6 10 13.6 1664 159.9 10
4 18.3 1543 205.0 10 16.8 1676 203.6 10 15.8 1187 198.7 10 14.9 1676 194.5 10 14.0 1676 188.9 10
5 16.8 1674 226.6 10 16.9 1674 217.6 10 16.1 1674 219.8 10 14.9 1674 220.2 10 14.2 1674 214.7 10
6 17.1 1712 240.8 10 15.9 1712 244.9 10 14.6 1713 247.3 10 14.7 1713 244.3 10 13.5 1714 235.6 10
7 17.9 1655 260.7 10 17.9 1656 256.8 10 16.0 1656 255.8 10 14.6 1656 260.6 10 13.4 1656 250.0 10
8 16.5 1692 279.8 10 15.2 1694 278.5 10 14.7 1692 281.7 10 14.1 1694 275.4 10 13.2 1692 267.1 10
9 14.9 1660 263.1 10 15.9 1536 280.1 10 14.0 1662 279.3 10 13.9 1662 278.6 10 13.3 1662 270.2 10
10 19.0 1710 281.0 10 16.3 1710 289.8 10 13.7 1710 293.6 10 14.1 1710 289.6 10 12.6 1710 284.8 10
11 16.7 1660 290.7 10 15.1 1660 288.7 10 13.8 1658 305.8 10 13.5 1674 295.1 10 12.2 1674 295.3 10
12 15.1 1668 307.2 10 15.8 1670 309.0 10 14.8 1531 313.1 10 13.6 1654 310.3 10 12.6 1652 294.6 10
13 14.8 1656 316.1 10 12.0 1656 296.3 10 14.0 1656 324.0 10 12.7 1170 323.0 10 13.4 1656 300.9 10
MEAN BODY WGT FOR WEEKS
1 TO 13 236.7 236.1 239.7 237.2 230.1
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==============================
1000 MG/L
----------------------
DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS
===============================
B 101.2 10
1 9.0 678 101.2 10
2 11.0 1699 122.4 10
3 12.1 1664 152.8 10
4 13.6 1186 160.3 10
5 12.8 1674 192.5 10
6 12.2 1712 217.8 10
7 12.9 1656 232.2 10
8 12.2 1692 248.0 10
9 11.6 1317 252.7 10
10 13.6 1707 265.5 10
11 10.8 1676 279.3 10
12 10.8 1652 281.9 10
13 11.6 1658 282.6 10
MEAN BODY WGT FOR WEEKS
1 TO 13 214.6
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5MG/L 125MG/L 250MG/L 500MG/L
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
===================================================================================================================================
B 89.1 10 90.5 10 88.6 10 89.7 10 89.2 10
1 14.1 970 89.1 10 14.0 970 90.5 10 13.0 970 88.6 10 11.7 970 89.7 10 10.3 970 89.2 10
2 14.3 1682 118.2 10 15.0 1698 121.8 10 13.3 1700 117.9 10 11.6 1699 117.6 10 10.5 1698 115.7 10
3 14.7 1682 135.7 10 14.9 1664 141.5 10 13.5 1664 136.3 10 11.7 1664 133.5 10 10.6 1664 131.0 10
4 16.1 1676 148.6 10 14.0 1187 154.9 10 12.5 1676 149.1 10 11.7 1676 147.2 10 10.6 1676 144.3 10
5 13.5 1674 157.4 10 13.8 1674 165.1 10 12.5 1674 158.9 10 11.0 1674 155.8 10 10.4 1674 153.9 10
6 12.7 1712 163.7 10 13.1 1712 173.0 10 11.7 1712 168.0 10 10.6 1713 165.0 10 9.7 1712 162.5 10
7 13.6 1193 169.2 10 13.4 1656 180.2 10 12.5 1656 176.1 10 11.0 1656 173.7 10 10.3 1656 169.9 10
8 13.0 1692 170.8 10 12.7 1693 181.7 10 11.4 1692 176.7 10 11.0 1553 175.4 10 9.6 1692 171.1 10
9 13.9 1661 180.7 10 13.5 1662 189.4 10 11.9 1662 183.5 10 11.2 1662 182.2 10 10.0 1661 178.5 10
10 13.0 1710 185.9 10 12.6 1710 192.0 10 11.0 1710 186.6 10 10.1 1710 186.6 10 9.2 1710 180.8 10
11 11.7 1660 188.2 10 12.6 1660 196.3 10 11.6 1279 182.2 10 9.8 1674 189.7 10 9.3 1674 184.8 10
12 11.2 1668 188.6 10 11.9 1670 199.3 10 10.6 1668 189.8 10 9.7 1654 189.7 10 9.1 1654 187.1 10
13 11.2 1656 189.8 10 12.7 1656 205.0 10 10.9 1656 195.2 10 9.4 1656 192.9 10 9.1 1656 189.0 10
MEAN BODY WGT FOR WEEKS
1 TO 13 160.5 168.5 162.2 161.5 158.3
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==============================
1000 MG/L
----------------------
DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS
===============================
B 88.0 10
1 8.3 972 88.0 10
2 8.9 1483 101.9 10
3 9.0 1664 122.4 10
4 9.1 1676 135.6 10
5 9.1 1674 145.2 10
6 8.9 1713 152.3 10
7 9.4 1656 160.6 10
8 8.8 1692 162.4 10
9 9.4 1660 168.5 10
10 8.3 1710 170.5 10
11 8.2 1676 174.9 10
12 8.0 1652 176.3 10
13 8.1 1656 179.1 10
MEAN BODY WGT FOR WEEKS
1 TO 13 149.1
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.