TDMS Study 96006-05 Pathology Tables
NTP Experiment-Test: 96006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/07/05
Route: GAVAGE DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE Time: 07:57:30
FINAL#1, REVISION#1 (MALE RATS ONLY)
Facility: BIORELIANCE
Chemical CAS #: 5407-04-5
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 VEHICLE CONTROL
Include 002 6.25 MG/KG
Include 003 12.5 MG/KG
Include 004 25 MG/KG
Include 005 50 MG/KG
Include 006 100 MG/KG
Include 007 VEHICLE CONTROL
Include 008 6.25 MG/KG
Include 009 12.5 MG/KG
Include 010 25 MG/KG
Include 011 50 MG/KG
Include 012 100 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/07/05
Route: GAVAGE DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE Time: 07:57:30
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FISCHER 344 RATS FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 9
Accidently Killed 1
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10)
Hepatodiaphragmatic Nodule 1
Pancreas (10) (10)
Infiltration Cellular, Focal, Lymphocyte 2 [1.0] 1 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (1) (1) (10)
Cyst 1 [2.0]
Bilateral, Cyst 1 [2.0]
Uterus (10) (10)
Hydrometra 2 [1.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/07/05
Route: GAVAGE DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE Time: 07:57:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/07/05
Route: GAVAGE DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE Time: 07:57:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 9 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 [1.0]
Pancreas (10) (10)
Infiltration Cellular, Focal, Lymphocyte 4 [1.0] 4 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Myocardium, Infiltration Cellular, Focal,
Lymphocyte 2 [1.0]
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ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/07/05
Route: GAVAGE DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE Time: 07:57:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10) (10) (10) (10)
Goblet Cell, Hypertrophy 1 [1.0] 2 [1.0] 2 [1.0] 1 [1.0] 3 [1.0] 7 [1.0]
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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