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TDMS Study 96006-05 Pathology Tables

NTP Experiment-Test: 96006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/07/05
Route: GAVAGE                                    DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE                      Time: 07:57:30

                                              FINAL#1, REVISION#1 (MALE RATS ONLY)




       Facility:  BIORELIANCE

       Chemical CAS #:  5407-04-5

       Lock Date:  07/20/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 002    6.25    MG/KG
                               Include 003    12.5    MG/KG
                               Include 004    25 MG/KG
                               Include 005    50 MG/KG
                               Include 006    100     MG/KG
                               Include 007    VEHICLE CONTROL
                               Include 008    6.25    MG/KG
                               Include 009    12.5    MG/KG
                               Include 010    25 MG/KG
                               Include 011    50 MG/KG
                               Include 012    100     MG/KG






















a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/07/05    
Route: GAVAGE                                    DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE                      Time: 07:57:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           
    Accidently Killed                                                                                                   1           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                             (10)         
      Hepatodiaphragmatic Nodule                       1                                                                            
   Pancreas                                           (10)                                                             (10)         
      Infiltration Cellular, Focal, Lymphocyte         2 [1.0]                                                          1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (1)          (1)                                    (10)         
      Cyst                                                                       1 [2.0]                                            
      Bilateral, Cyst                                               1 [2.0]                                                         
   Uterus                                             (10)                                                             (10)         
      Hydrometra                                       2 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/07/05    
Route: GAVAGE                                    DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE                      Time: 07:57:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hyperplasia                         1 [2.0]                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/07/05    
Route: GAVAGE                                    DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE                      Time: 07:57:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                          1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10            9           10           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                                    1 [1.0]                                                         
   Pancreas                                           (10)                                                             (10)         
      Infiltration Cellular, Focal, Lymphocyte         4 [1.0]                                                          4 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Myocardium, Infiltration Cellular, Focal,                                                                                     
         Lymphocyte                                                                                                     2 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/07/05    
Route: GAVAGE                                    DIMETHYLAMINOPROPYL CHLORIDE, HYDROCHLORIDE                      Time: 07:57:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia                                                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Goblet Cell, Hypertrophy                         1 [1.0]      2 [1.0]      2 [1.0]      1 [1.0]      3 [1.0]      7 [1.0]     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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