https://ntp.niehs.nih.gov/go/27979

TDMS Study 96006-06 Pathology Tables

NTP Experiment-Test: 96006-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                     Date: 03/11/02
Route: GAVAGE                                                                                                     Time: 14:07:37
                                                         Final #1/Mice
       Facility:  BIORELIANCE
       Chemical CAS #:  5407-04-5
       Lock Date:  07/20/01
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 96006-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                     Date: 03/11/02  
Route: GAVAGE                                                                                                     Time: 14:07:37  
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         B6C3F1 MICE FEMALE                        VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100             
                                                   CONTROL      MG/KG        MG/KG                                  MG/KG           
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            7           
    Natural Death                                                                                                       1           
  Animals Examined Microscopically                    10            1            1                                     10           
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 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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                                                             Page   2                                                               
NTP Experiment-Test: 96006-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                     Date: 03/11/02  
Route: GAVAGE                                                                                                     Time: 14:07:37  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100             
                                                   CONTROL      MG/KG        MG/KG                                  MG/KG           
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   3                                                               
NTP Experiment-Test: 96006-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                     Date: 03/11/02  
Route: GAVAGE                                                                                                     Time: 14:07:37  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100             
                                                   CONTROL      MG/KG        MG/KG                                  MG/KG           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10                                                               10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 96006-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                     Date: 03/11/02  
Route: GAVAGE                                                                                                     Time: 14:07:37  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100             
                                                   CONTROL      MG/KG        MG/KG                                  MG/KG           
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
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