TDMS Study 96006-06 Pathology Tables
NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 Final #1/Mice Facility: BIORELIANCE Chemical CAS #: 5407-04-5 Lock Date: 07/20/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | + + + + M + I + + + | 8 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M M M M + + | 6 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + I + + + I | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | M + M + + + + + + M | 7 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + I + + + + + + | 9 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6.25 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6.25 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 6| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | A I A + A + + + + + | 6 | |__________________________________________________________________________|____________| Intestine Large, Colon | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Intestine Large, Rectum | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A + A + M + + + + + | 7 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + A + M + + + + + | 7 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + A + M + + + + + | 7 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | A + A + A + + + + + | 7 | |__________________________________________________________________________|____________| Salivary Glands | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Forestomach | A + A + A + + + + + | 7 | |__________________________________________________________________________|____________| Stomach, Glandular | A + A + A + + + + + | 7 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 6| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | A + A + A + + + + + | 7 | |__________________________________________________________________________|____________| Adrenal Medulla | A + A + A + + + + + | 7 | |__________________________________________________________________________|____________| Islets, Pancreatic | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Parathyroid Gland | M M + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | A + A + + + I + + + | 7 | |__________________________________________________________________________|____________| Thyroid Gland | A + A + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | A + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Ovary | A + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Uterus | A + A + + + + + + + | 8 | |__________________________________________________________________________|____________| Vagina | A + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | A + A + A + + + + + | 7 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | A + A + M + + + + + | 7 | |__________________________________________________________________________|____________| Spleen | A + A + A + + + + + | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 6| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | A M A + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | A + A + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + A + + + + + + + | 9 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | A + A + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | A + A + A + + + + + | 7 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | A + A + + + + + + + | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 6| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Urinary Bladder | A + A + A + + + + + | 7 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + I + + + | 9 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + M + + + + + + + | 9 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + I M M + + + + + | 7 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + M M + M + + + M + | 6 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + I + + + + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + M + + I + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + | 9 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | M + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | M + I I + + + + I + | 6 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M M + M + M M M | 4 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + I + I + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 96006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SUBCHRON 90-DAY DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Date: 03/11/02 Route: GAVAGE Time: 14:08:15 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------