TDMS Study 93022-03 Pathology Tables
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
13 WEEK SUBCHRONIC
Facility: Southern Research Institute
Chemical CAS #: 25152-84-5
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M M M + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X X X X | 4 |
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 3 3 1 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 9 |
Hemorrhage | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
100 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + M + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Respiratory Epithelium, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
200 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + | 3 |
Hydrometra | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
200 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
400 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Edema | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Epithelium, Degeneration | 1 1 | 2 1.0|
Epithelium, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Exudate | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
400 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
800 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Edema | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 | 9 1.1|
Epithelium, Degeneration | 1 1 2 2 2 1 1 1 1 1 | 10 1.3|
Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
800 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + I + + + + | 9 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + I I + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Exudate | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X | 1 |
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Hemorrhage | 1 2 1 2 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + M M | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 2 2 | 4 1.5|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
200 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 9 |
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
Olfactory Epithelium, Necrosis | 1 | 1 1.0|
Sinus, Exudate | 1 | 1 1.0|
Turbinate, Osteofibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
200 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
400 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Edema | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Epithelium, Degeneration | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thymus | + | 1 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Exudate | 1 1 | 2 1.0|
Olfactory Epithelium, Atrophy | 3 | 1 3.0|
Turbinate, Osteofibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
400 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
800 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
Erosion, Focal | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Epithelium, Degeneration | 1 1 2 1 1 | 5 1.2|
Epithelium, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93022-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:51
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
800 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 9 |
Hemorrhage | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + M + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 | 3 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Exudate | 1 1 1 1 1 1 | 6 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 2 1 1 2 | 4 1.5|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Turbinate, Osteofibrosis | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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---------- END OF REPORT ----------
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