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P05 - Incidence Rates of Neoplasms by Anatomic Site (systemic lesions abridged) (Rats)

NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03

Route: GAVAGE                                                                                                     Time: 09:12:37



                                                           FINAL/RATS









       Facility:  Battelle Columbus Laboratory



       Chemical CAS #:  140-67-0



       Lock Date:  09/03/02



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All



a  Number of animals examined microscopically at site and number of animals with lesion



                                                              Page   1





NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 09:12:37  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         FISCHER 344 RATS FEMALE                   0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

DISPOSITION SUMMARY                                                                                                                 

                                                                                                                                    

  Animals Initially in Study                          10           10           10           10           10           10           

  Early Deaths                                                                                                                      

  Survivors                                                                                                                         

    Terminal Sacrifice                                10           10           10           10           10           10           

                                                                                                                                    

  Animals Examined Microscopically                    10           10           10           10           10           10           

                                                                                                                                    

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ALIMENTARY SYSTEM                                                                                                                  

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 CARDIOVASCULAR SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ENDOCRINE SYSTEM                                                                                                                   

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENERAL BODY SYSTEM                                                                                                                

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENITAL SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 HEMATOPOIETIC SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 09:12:37  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         FISCHER 344 RATS FEMALE                   0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

 INTEGUMENTARY SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 MUSCULOSKELETAL SYSTEM                                                                                                             

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 NERVOUS SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 RESPIRATORY SYSTEM                                                                                                                 

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 SPECIAL SENSES SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 URINARY SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 09:12:37  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         FISCHER 344 RATS MALE                     0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

DISPOSITION SUMMARY                                                                                                                 

                                                                                                                                    

  Animals Initially in Study                          10           10           10           10           10           10           

  Early Deaths                                                                                                                      

  Survivors                                                                                                                         

    Terminal Sacrifice                                10           10           10           10           10           10           

                                                                                                                                    

  Animals Examined Microscopically                    10           10           10           10           10           10           

                                                                                                                                    

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ALIMENTARY SYSTEM                                                                                                                  

                                                                                                                                    

   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         

      Cholangiocarcinoma, Multiple                                                                                      2 (20%)     

      Hepatocellular Adenoma                                                                                            1 (10%)     

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 CARDIOVASCULAR SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ENDOCRINE SYSTEM                                                                                                                   

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENERAL BODY SYSTEM                                                                                                                

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENITAL SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 HEMATOPOIETIC SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 09:12:37  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         FISCHER 344 RATS MALE                     0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

 INTEGUMENTARY SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 MUSCULOSKELETAL SYSTEM                                                                                                             

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 NERVOUS SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 RESPIRATORY SYSTEM                                                                                                                 

                                                                                                                                    

   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         

      Hamartoma                                                     1 (10%)                                                         

                                                                                                                                    

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 SPECIAL SENSES SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 URINARY SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 09:12:37  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         FISCHER 344 RATS MALE                     0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

TUMOR SUMMARY                                                                                                                       

                                                                                                                                    

   Total Animals with Primary Neoplasms (b)                         1                                               3               

     Total Primary Neoplasms                                        1                                               3               

                                                                                                                                    

   Total Animals with Benign Neoplasms                              1                                               1               

     Total Benign Neoplasms                                         1                                               1               

                                                                                                                                    

   Total Animals with Malignant Neoplasms                                                                           2               

     Total Malignant Neoplasms                                                                                      2               

                                                                                                                                    

   Total Animals with Metastatic Neoplasms                                                                                          

     Total Metastatic Neoplasm                                                                                                      

                                                                                                                                    

   Total Animals with Malignant Neoplasms                                                                                           

   Uncertain Primary Site                                                                                                           

                                                                                                                                    

   Total Animals with Neoplasms Uncertain-                                                                                          

   Benign or Malignant                                                                                                              

     Total Uncertain Neoplasms                                                                                                      

                                                                                                                                    

                                                                                                                                    

____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

   
                                                                                                                                    

                                                             Page   6                                                               

                                                                                                                                   

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                             ----------              END OF REPORT             ----------                                           

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