P05 - Incidence Rates of Neoplasms by Anatomic Site (systemic lesions abridged) (Rats)
NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
FINAL/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 140-67-0
Lock Date: 09/03/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 37.5 75 150 300 600
MG/KG MG/KG MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 37.5 75 150 300 600
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 37.5 75 150 300 600
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Cholangiocarcinoma, Multiple 2 (20%)
Hepatocellular Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 37.5 75 150 300 600
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Hamartoma 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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NTP Experiment-Test: 60946-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 90-DAY ESTRAGOLE Date: 10/08/03
Route: GAVAGE Time: 09:12:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 37.5 75 150 300 600
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 3
Total Primary Neoplasms 1 3
Total Animals with Benign Neoplasms 1 1
Total Benign Neoplasms 1 1
Total Animals with Malignant Neoplasms 2
Total Malignant Neoplasms 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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