TR 341 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NITROFURANTOIN
NTP Experiment-Test: 05051-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
Facility: Southern Research Institute
Chemical CAS #: 67-20-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 19 4 2
Moribund 12 9 11
Survivors
Dead 1
Terminal Sacrifice 19 36 37
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (41) (39) (42)
Dilatation 2 (5%)
Liver (50) (50) (50)
Basophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Necrosis, Multifocal 1 (2%) 2 (4%) 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Kupffer Cell, Pigmentation 1 (2%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 17 (34%)
Mesentery (21) (2) (8)
Cyst 1 (5%)
Hemorrhage, Focal 1 (5%)
Inflammation, Acute, Multifocal, Suppurative 14 (67%)
Inflammation, Focal, Subacute 1 (5%)
Fat, Necrosis, Focal 4 (19%) 1 (50%) 3 (38%)
Pancreas (47) (50) (50)
Abscess 1 (2%)
Atrophy 3 (6%) 1 (2%) 2 (4%)
Inflammation, Subacute 1 (2%)
Duct, Cyst 1 (2%) 2 (4%)
Stomach, Forestomach (49) (49) (50)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute, Focal, Suppurative 1 (2%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (49) (49) (49)
Edema 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Congestion 1 (2%)
Cyst 4 (8%)
Degeneration, Fatty 1 (2%)
Spindle Cell, Hyperplasia 3 (6%) 41 (82%) 45 (90%)
Adrenal Gland, Medulla (48) (49) (49)
Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Pituitary Gland (48) (44) (49)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 3 (7%) 2 (4%)
Thyroid Gland (48) (49) (50)
Follicle, Cyst 2 (4%) 2 (4%)
Follicle, Degeneration, Cystic 3 (6%)
Follicle, Hyperplasia, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Cyst 1 (100%)
Ovary (50) (50) (50)
Abscess 18 (36%)
Atrophy 48 (96%) 49 (98%)
Cyst 14 (28%) 10 (20%) 15 (30%)
Hemorrhage 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%)
Mineralization 2 (4%) 3 (6%)
Uterus (50) (50) (50)
Hydrometra 2 (4%) 1 (2%)
Hyperplasia, Cystic 49 (98%) 49 (98%) 49 (98%)
Inflammation, Acute, Suppurative 11 (22%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (49)
Deep Cervical, Inflammation, Acute, Focal,
Suppurative 2 (4%)
Iliac, Hyperplasia 2 (4%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hyperplasia 1 (2%)
Renal, Congestion 1 (2%)
Renal, Hyperplasia 6 (12%)
Lymph Node, Mandibular (50) (50) (45)
Congestion 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Acute, Focal, Suppurative 1 (2%)
Lymph Node, Mesenteric (45) (45) (48)
Angiectasis 3 (7%)
Hyperplasia 2 (4%)
Spleen (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 21 (43%) 4 (8%) 2 (4%)
Hemorrhage 1 (2%)
Thymus (47) (48) (48)
Cyst 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Mediastinum, Inflammation, Acute, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (48)
Duct, Cyst 3 (6%) 3 (6%)
Skin (50) (50) (50)
Alopecia 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (2)
Inflammation, Acute, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Compression 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Multifocal, Subacute 25 (50%) 19 (38%) 19 (38%)
Inflammation, Subacute 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%)
Mediastinum, Inflammation, Acute, Suppurative 2 (4%)
Nose (48) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (5) (1)
Hemorrhage 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 2 (4%)
Nephropathy 1 (2%)
Cortex, Infarct 3 (6%) 1 (2%)
Cortex, Mineralization, Diffuse 1 (2%)
Medulla, Mineralization 7 (14%)
Renal Tubule, Degeneration, Multifocal 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Necrosis, Multifocal 1 (2%)
Urinary Bladder (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 7 12 2
Moribund 15 9 14
Survivors
Terminal Sacrifice 28 29 33
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (45) (37)
Hyperplasia 1 (3%)
Intestine Large, Rectum (48) (47) (50)
Cyst 2 (4%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Subacute 2 (4%) 1 (2%)
Perforation 1 (2%)
Prolapse 3 (6%) 1 (2%) 2 (4%)
Intestine Small, Jejunum (49) (45) (49)
Cyst 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 1 (2%)
Cyst 1 (2%)
Fibrosis, Focal 1 (2%)
Granuloma, Multiple 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Mixed Cell Focus 2 (4%)
Necrosis, Multifocal 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Mesentery (3) (1) (2)
Inflammation, Acute, Multifocal, Suppurative 2 (67%)
Inflammation, Focal, Subacute 1 (33%)
Thrombosis 1 (33%)
Stomach, Forestomach (49) (48) (49)
Cyst 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Inflammation, Acute, Focal, Suppurative 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Mineralization 1 (2%)
Stomach, Glandular (50) (48) (49)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (10) (12) (4)
Dysplasia 10 (100%) 12 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 2 (4%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Hyperplasia, Focal 1 (2%) 2 (4%)
Spindle Cell, Hyperplasia 5 (10%) 3 (6%) 3 (6%)
Spindle Cell, Hyperplasia, Focal 1 (2%)
Adrenal Gland, Medulla (49) (48) (49)
Hyperplasia 3 (6%) 6 (13%) 5 (10%)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (46) (48) (43)
Pars Distalis, Cyst 1 (2%)
Thyroid Gland (48) (47) (48)
Hyperplasia, Cystic 1 (2%)
Follicle, Cyst 1 (2%) 3 (6%)
Follicle, Degeneration 1 (2%) 1 (2%) 1 (2%)
Follicle, Hyperplasia, Cystic 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50)
Atypia Cellular 26 (52%)
Depletion Cellular 1 (2%) 1 (2%) 15 (30%)
Granuloma Sperm 3 (6%)
Penis (2) (8) (1)
Developmental Malformation 2 (100%) 8 (100%) 1 (100%)
Preputial Gland (9) (2) (4)
Inflammation, Acute, Suppurative 1 (11%)
Inflammation, Subacute 5 (56%)
Duct, Cyst 6 (67%) 2 (100%) 4 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (49) (50) (50)
Inflammation, Acute, Suppurative 4 (8%) 4 (8%)
Inflammation, Chronic 1 (2%) 1 (2%)
Seminal Vesicle (6) (4) (1)
Dilatation 3 (50%) 4 (100%) 1 (100%)
Inflammation, Acute, Suppurative 2 (33%)
Inflammation, Chronic 1 (17%) 1 (25%)
Testes (49) (49) (50)
Aspermatogenesis 1 (2%) 1 (2%) 16 (32%)
Atrophy 1 (2%)
Mineralization 1 (2%) 1 (2%)
Germinal Epithelium, Degeneration 3 (6%) 23 (46%)
Seminiferous Tubule, Dilatation, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Anemia 1 (50%)
Lymph Node (50) (49) (49)
Axillary, Hyperplasia 1 (2%)
Deep Cervical, Hyperplasia 1 (2%)
Iliac, Hyperplasia 1 (2%) 1 (2%)
Inguinal, Hyperplasia 1 (2%)
Lymph Node, Mesenteric (47) (46) (44)
Angiectasis 6 (13%)
Ectasia 1 (2%)
Hyperplasia 1 (2%)
Thrombosis 1 (2%)
Spleen (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Atrophy 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 11 (22%) 4 (8%)
Necrosis, Focal 1 (2%)
Thymus (44) (43) (41)
Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Alopecia 4 (8%) 5 (10%) 3 (6%)
Alopecia, Multifocal 3 (6%)
Fibrosis 7 (14%) 5 (10%) 12 (24%)
Fungus 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Inflammation, Acute, Suppurative 2 (4%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Granulomatous 2 (4%) 1 (2%)
Inflammation, Focal, Subacute 7 (14%) 12 (24%) 9 (18%)
Mineralization, Focal 1 (2%) 1 (2%) 2 (4%)
Ulcer 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 3 (6%)
Fibrosis, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Multifocal, Subacute 32 (64%) 34 (68%) 30 (60%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Nose (42) (44) (48)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Calculus Gross Observation 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Nephropathy 3 (6%)
Cortex, Infarct 1 (2%)
Cortex, Infarct, Focal 1 (2%) 2 (4%) 1 (2%)
Medulla, Mineralization 17 (34%)
Papilla, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:13:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Degeneration, Multifocal 1 (2%) 1 (2%)
Renal Tubule, Dilatation 14 (28%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Necrosis, Multifocal 1 (2%)
Renal Tubule, Nephropathy 1 (2%) 1 (2%)
Ureter (1)
Inflammation, Acute, Suppurative 1 (100%)
Urethra (2)
Inflammation, Subacute, Suppurative 1 (50%)
Bulbourethral Gland, Dilatation 1 (50%)
Urinary Bladder (50) (49) (50)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Inflammation, Acute, Suppurative 2 (4%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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