TR 341 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NITROFURANTOIN
NTP Experiment-Test: 05051-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
Facility: Southern Research Institute
Chemical CAS #: 67-20-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 19 4 2
Moribund 12 9 11
Survivors
Dead 1
Terminal Sacrifice 19 36 37
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (41) (39) (42)
Intestine Large, Cecum (43) (49) (50)
Intestine Small, Ileum (44) (47) (50)
Intestine Small, Jejunum (45) (48) (50)
Liver (50) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 2 (4%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 7 (14%)
Ito Cell Tumor NOS 1 (2%) 1 (2%)
Mesentery (21) (2) (8)
Fibrosarcoma 1 (13%)
Sarcoma 1 (50%) 1 (13%)
Pancreas (47) (50) (50)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma 1 (2%)
Salivary Glands (49) (50) (50)
Stomach, Forestomach (49) (49) (50)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Glandular, Fibrosarcoma, Metastatic,
Mesentery 1 (2%)
Stomach, Glandular (49) (49) (49)
Sarcoma 1 (2%)
Tongue (1)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Medulla (48) (49) (49)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (47) (50) (49)
Carcinoma 1 (2%)
Pituitary Gland (48) (44) (49)
Pars Distalis, Adenoma 3 (6%) 1 (2%) 2 (4%)
Thyroid Gland (48) (49) (50)
Follicular Cell, Adenoma 3 (6%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (50) (50)
Adenoma, Tubular 5 (10%)
Cystadenoma 1 (2%)
Cystadenoma, Papillary 2 (4%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 3 (6%) 1 (2%)
Hemangioma 1 (2%) 1 (2%)
Mixed Tumor Benign 4 (8%)
Neoplasm NOS 1 (2%)
Uterus (50) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Polyp Stromal 2 (4%) 2 (4%) 1 (2%)
Sarcoma Stromal 2 (4%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (49)
Lymph Node, Mandibular (50) (50) (45)
Lymph Node, Mesenteric (45) (45) (48)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Spleen (49) (50) (50)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Hemangiosarcoma 1 (2%)
Thymus (47) (48) (48)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (48)
Adenoacanthoma 1 (2%)
Adenocarcinoma 5 (10%) 3 (6%)
Adenocarcinoma, Multiple 1 (2%)
Skin (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1) (2)
Fibrosarcoma, Metastatic, Mesentery 1 (50%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Meningioma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%)
Mediastinum, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (5) (1)
Adenocarcinoma 1 (50%) 1 (20%)
Adenoma 1 (50%) 2 (40%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Sarcoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 5 (10%) 6 (12%)
Lymphoma Malignant Lymphocytic 11 (22%) 10 (20%) 17 (34%)
Lymphoma Malignant Mixed 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 35 41
Total Primary Neoplasms 44 55 67
Total Animals with Benign Neoplasms 15 15 22
Total Benign Neoplasms 17 17 27
Total Animals with Malignant Neoplasms 21 27 31
Total Malignant Neoplasms 27 37 38
Total Animals with Metastatic Neoplasms 1 2 3
Total Metastatic Neoplasm 2 3 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2
Total Uncertain Neoplasms 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 7 12 2
Moribund 15 9 14
Survivors
Terminal Sacrifice 28 29 33
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (49) (50)
Intestine Small, Ileum (47) (43) (47)
Intestine Small, Jejunum (49) (45) (49)
Liver (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 8 (16%) 6 (12%) 7 (14%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 4 (8%) 3 (6%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Mesentery (3) (1) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (50%)
Pancreas (50) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Stomach, Forestomach (49) (48) (49)
Fibrosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Adenoma 1 (2%)
Spindle Cell, Carcinoma 1 (2%)
Adrenal Gland, Medulla (49) (48) (49)
Page 7
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Benign 4 (8%) 1 (2%)
Islets, Pancreatic (50) (49) (50)
Adenoma 1 (2%)
Thyroid Gland (48) (47) (48)
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50)
Preputial Gland (9) (2) (4)
Hemangiosarcoma 1 (11%)
Testes (49) (49) (50)
Interstitial Cell, Adenoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Bone Marrow (50) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (49) (49)
Bronchial, Mediastinal, Fibrosarcoma,
Metastatic, Stomach 1 (2%)
Lymph Node, Mandibular (45) (41) (46)
Bronchial, Mediastinal, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Lymph Node, Mesenteric (47) (46) (44)
Spleen (50) (49) (50)
Hemangiosarcoma 1 (2%)
Thymus (44) (43) (41)
Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Melanoma Benign 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Page 8
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibrosarcoma 7 (14%) 5 (10%) 11 (22%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 2 (4%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant,
Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Fibrosarcoma, Metastatic, Stomach 1 (100%)
Diaphragm, Intercostal, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 2 (4%) 4 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Fibrosarcoma, Metastatic, Stomach 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (3) (2)
Adenoma 2 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Fibrosarcoma, Metastatic, Stomach 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia 1 (2%)
Lymphoma Malignant Histiocytic 2 (4%) 1 (2%)
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Lymphocytic 5 (10%) 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 4 (8%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05051-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 14:37:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 31 27 33
Total Primary Neoplasms 53 35 42
Total Animals with Benign Neoplasms 12 11 14
Total Benign Neoplasms 17 15 14
Total Animals with Malignant Neoplasms 28 20 24
Total Malignant Neoplasms 36 20 28
Total Animals with Metastatic Neoplasms 1 2 3
Total Metastatic Neoplasm 5 2 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 63529-63529/63529
--multipart-boundary--