TR 341 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05051 NITROFURANTOIN TIME: 14:53:11
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55196
CONT: NOIES28024 CAS: 67-20-9
PATHOLOGIST: H. GILES
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05051 NITROFURANTOIN TIME: 14:53:11
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55196
CONT: NOIES28024 CAS: 67-20-9
PATHOLOGIST: H. GILES
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 53 58 61 81 127 207 408 449 457 460 |
| 473 533 611 631 651 664 688 688 697 708 |
| 713 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.13% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 55 156 186 236 335 378 496 530 574 580 |
| 602 605 614 622 631 660 673 699 714 723 |
| 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 65 527 575 576 602 621 639 660 667 669 |
| 684 687 694 695 729 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 92.0 90.0 88.0 88.0 86.0 78.0 76.0 76.0 68.0 56.0 |
|CONTROL | |
| | |
|0.13% | 98.0 96.0 92.0 90.0 88.0 88.0 84.0 76.0 68.0 58.0 |
| | |
| | |
|0.25% | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 90.0 84.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.13% 0.25% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 58.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.173N P=0.897N P=0.197N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 460.5 513.9 613.7 |
|NATURAL DEATHS (C) | (52.9) (44.8) (39.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 611.4 639.2 692.8 |
|(STANDARD ERROR) | (29.9) (24.0) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 148 444 452 456 475 500 521 524 534 561 |
| 589 593 601 603 607 607 631 635 649 654 |
| 667 686 687 696 708 714 714 717 722 728 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.13% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 469 575 596 609 617 670 687 694 696 706 |
| 708 709 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 568 625 630 639 649 656 660 678 696 708 |
| 729 729 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 98.0 98.0 98.0 98.0 90.0 82.0 72.0 60.0 38.0 |
|CONTROL | |
| | |
|0.13% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 74.0 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 86.0 74.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.13% 0.25% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.0% 74.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.4 649.6 668.9 |
|NATURAL DEATHS (C) | (22.0) (20.2) (13.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.4 709.1 714.1 |
|(STANDARD ERROR) | (16.3) ( 7.2) ( 5.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROFURANTOIN
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.13% = 2
0.25% = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3
|
| 113 2 3
| 2 2 3 3
95 +
| 1 1 2 2
| 1 1 2 2 3 3
|
90 + 1 1 2 2 3 3
|
P | 1 2 1 2 3 3
E | 1 1 2 2 3 3
R 85 +
C | 11 2 2 33
E | 22
N |
T 80 + 1 1 2 2 3 3
|
S | 1 1 22 33
U | 1 21 33
R 75 +
V | 12 1
I | 2 1 1 3 3
V |
A 70 + 2 1 1
L |
| 1 2 1 3
| 2 2
65 +
| 11 2
| 1 1 2
|
60 +
|
| 2 2
| 1 1
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
NITROFURANTOIN
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.13% = 2
0.25% = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 1 2 32 3
| 1 11 2 22 3 3
| 1 1 2 2 33
90 + 1 1 2 33 2
| 1 1 3 32 2
P | 1 1 3 3 22
E | 1 1 223
R 80 + 1 1 22 3
C |
E | 111 2 2
N |
T 70 +
| 1 1
S | 1 1
U | 11
R 60 + 1 1
V | 1 1
I | 111
V | 1 1
A 50 +
L |
| 111
|
40 +
| 1 1
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
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