TR 341 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NITROFURANTOIN
NTP Experiment-Test: 05051-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
Facility: Southern Research Institute
Chemical CAS #: 67-20-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.06% 0.13%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 22 12 17
Dead 3 12 2
Survivors
Terminal Sacrifice 25 26 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50) (50)
Neoplastic Nodule 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mesentery (8) (9) (10)
Sarcoma Stromal, Metastatic, Uterus 1 (13%)
Pancreas (50) (48) (49)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (49) (49) (50)
Adenocarcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Adenoma 2 (4%) 1 (2%)
Adrenal Gland, Medulla (48) (48) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%) 4 (8%)
Islets, Pancreatic (50) (48) (49)
Carcinoma 1 (2%)
Parathyroid Gland (49) (50) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (48) (48)
Pars Distalis, Adenoma 23 (46%) 16 (33%) 21 (44%)
Pars Distalis, Carcinoma 3 (6%) 9 (19%) 2 (4%)
Thyroid Gland (50) (50) (50)
Page 2
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.06% 0.13%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 3 (6%) 2 (4%) 2 (4%)
C-Cell, Adenoma, Multiple 1 (2%) 2 (4%)
C-Cell, Carcinoma 4 (8%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (38) (42)
Adenoma 1 (2%) 7 (18%) 4 (10%)
Carcinoma 4 (9%) 3 (8%)
Ovary (50) (50) (50)
Uterus (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 9 (18%) 16 (32%) 10 (20%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 2 (4%)
Cervix, Sarcoma Stromal 1 (2%)
Cervix, Squamous Cell Carcinoma 1 (2%)
Endometrium, Adenoma 2 (4%)
Endometrium, Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (9) (2) (8)
Bone Marrow (49) (48) (50)
Sarcoma 1 (2%)
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (48) (47) (50)
Lymph Node, Mesenteric (50) (48) (49)
Spleen (50) (49) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Thymus (43) (34) (40)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50)
Adenocarcinoma 6 (12%) 4 (8%)
Adenocarcinoma, Multiple 1 (2%)
Fibroadenoma 23 (47%) 16 (32%) 16 (32%)
Page 3
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.06% 0.13%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Fibroadenoma, Multiple 5 (10%) 10 (20%) 15 (30%)
Fibrosarcoma 1 (2%)
Skin (50) (49) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Foot, Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Diaphragm, Sarcoma Stromal, Metastatic,
Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.06% 0.13%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 13 (26%) 13 (26%) 9 (18%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.06% 0.13%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 46
Total Primary Neoplasms 109 116 100
Total Animals with Benign Neoplasms 43 41 42
Total Benign Neoplasms 70 79 82
Total Animals with Malignant Neoplasms 31 28 17
Total Malignant Neoplasms 39 37 18
Total Animals with Metastatic Neoplasms 1 1 3
Total Metastatic Neoplasm 7 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 23 22 21
Dead 3 1 3
Survivors
Moribund 1
Terminal Sacrifice 23 27 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (48)
Polyp Adenomatous 1 (2%)
Muscularis, Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (50) (49) (47)
Intestine Small, Jejunum (50) (50) (48)
Cystadenocarcinoma 1 (2%)
Liver (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 1 (2%) 2 (4%)
Neoplastic Nodule, Multiple 1 (2%)
Mesentery (6) (9) (6)
Pancreas (50) (50) (49)
Acinus, Adenoma 2 (4%)
Stomach (49) (50) (50)
Stomach, Forestomach (49) (50) (49)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Pheochromocytoma Malignant 3 (6%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 18 (36%) 16 (32%) 21 (42%)
Pheochromocytoma Benign, Multiple 5 (10%) 4 (8%) 2 (4%)
Page 7
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (50) (50) (49)
Adenoma 2 (4%) 2 (4%) 1 (2%)
Carcinoma 2 (4%)
Pituitary Gland (50) (50) (50)
Pars Distalis, Adenoma 10 (20%) 12 (24%) 13 (26%)
Pars Distalis, Carcinoma 1 (2%) 2 (4%) 3 (6%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 2 (4%) 7 (14%) 6 (12%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 3 (6%) 1 (2%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Preputial Gland (48) (50) (47)
Adenoma 6 (13%) 4 (8%)
Adenoma, Multiple 1 (2%)
Carcinoma 6 (13%) 6 (12%)
Prostate (50) (50) (49)
Seminal Vesicle (50) (50) (50)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 13 (26%) 4 (8%) 15 (30%)
Interstitial Cell, Adenoma, Multiple 34 (68%) 41 (82%) 6 (12%)
Tunic, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (18) (13) (10)
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Bronchial, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
Lymph Node, Mandibular (46) (50) (47)
Lymph Node, Mesenteric (49) (48) (49)
Spleen (50) (50) (50)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
Page 8
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (40) (36) (34)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (49) (46)
Adenoma 1 (2%)
Fibroadenoma 2 (4%) 4 (8%) 2 (4%)
Skin (50) (50) (50)
Basal Cell Carcinoma 3 (6%) 3 (6%)
Carcinoma 1 (2%)
Keratoacanthoma 4 (8%) 5 (10%) 4 (8%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 2 (4%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Basosquamous Tumor
Benign 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 2 (4%)
Subcutaneous Tissue, Neoplasm NOS 1 (2%)
Subcutaneous Tissue, Schwannoma NOS 1 (2%)
Subcutaneous Tissue, Sebaceous Gland, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Femur, Osteosarcoma 1 (2%) 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Carcinoma, Metastatic, Skin 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Bronchus, Squamous Cell Carcinoma 1 (2%)
Pleura, Mediastinum, Alveolar/Bronchiolar
Carcinoma, Metastatic, Uncertain Primary
Site 1 (2%)
Nose (50) (49) (48)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (16) (13) (26)
Pinna, Schwannoma Malignant 1 (6%)
Harderian Gland (1) (5) (4)
Zymbal's Gland (2) (1)
Carcinoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 23 (46%) 14 (28%) 15 (30%)
Mesothelioma Benign 1 (2%) 2 (4%)
Mesothelioma Malignant 3 (6%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05051-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROFURANTOIN Date: 09/07/94
Route: DOSED FEED Time: 07:01:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.13% 0.25%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 48
Total Primary Neoplasms 151 156 120
Total Animals with Benign Neoplasms 49 47 40
Total Benign Neoplasms 102 116 84
Total Animals with Malignant Neoplasms 37 31 30
Total Malignant Neoplasms 49 39 35
Total Animals with Metastatic Neoplasms 2 2 2
Total Metastatic Neoplasm 2 5 5
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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