TR 341 Rat Pathology Tables
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
Facility: Southern Research Institute
Chemical CAS #: 67-20-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|
| 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Edema, Diffuse | 4 |
Submucosa, Hemorrhage, Multifocal | 3 |
Submucosa, Inflammation, Diffuse | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 X 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3|
Basophilic Focus, Multiple | 2 2 2 |
Clear Cell Focus | 3 |
Cytologic Alterations, Focal | |
Developmental Malformation | |
Hyperplasia, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Granulomatous, | |
Multifocal | 3 |
Necrosis, Coagulative, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 3 |
Vacuolization Cytoplasmic, Multifocal| 2 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2|
Acinus, Atrophy, Multifocal | 3 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3 |
Ulcer, Focal | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|
| 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 2 2 2 2 2 3 3 3 3 2 2 2 3 2 3 2|
Inflammation, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Cyst | X |
Degeneration, Fatty, Focal | |
Hyperplasia, Focal | 3 2 2 |
Vacuolization Cytoplasmic, Diffuse | 4 |
Vacuolization Cytoplasmic, Focal | 2 2 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M M + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 4 4 2 3 4 4 4 4 3 4 3 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Cyst, Multiple | X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Necrosis | 2 |
Pars Distalis, Pigmentation | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 2 3 |
C-Cell, Hyperplasia, Multifocal | 2 2 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M M + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | |
Duct, Cyst | X X X X X X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|
| 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic, Focal | |
Cervix, Cyst | X |
Cervix, Inflammation, Suppurative | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Anemia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + M + + + + M M + + M + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 1 |
Hyperplasia, Lobular | 3 2 3 2|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Cranium, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|
| 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
Degeneration, Multifocal | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Inflammation, Chronic | 2 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 3 |
Lumen, Fungus | X |
Lumen, Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Harderian Gland | |
Fibrosis | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 |
Nephropathy, Chronic | 2 2 3 2 2 3 2 2 1 2 3 4 2 2 2 2 3 2 2 2 3 3|
Pelvis, Infiltration Cellular, | |
Lymphocyte | |
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3| |
| 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Submucosa, Edema, Diffuse | | 1 4.0|
Submucosa, Hemorrhage, Multifocal | | 1 3.0|
Submucosa, Inflammation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 3.0|
Basophilic Focus, Multiple | 2 X 3 1 2 2 2| 10 2.0|
Clear Cell Focus | | 1 3.0|
Cytologic Alterations, Focal | 2 | 1 2.0|
Developmental Malformation | X X | 2 |
Hyperplasia, Focal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 2.5|
Inflammation, Focal, Granulomatous | | 2 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 2 2.5|
Necrosis, Coagulative, Focal | 3 | 2 3.0|
Vacuolization Cytoplasmic, Focal | 3 2 | 3 2.7|
Vacuolization Cytoplasmic, Multifocal| | 2 2.5|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis, Focal | 3 3 3 3 2 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 3 2 2| 5 2.2|
Acinus, Atrophy, Multifocal | | 1 3.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3| |
| 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer, Focal | 4 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 3 3 3 3 2 2 2 3 2 3 3 2 2 3 2 4 2| 33 2.5|
Inflammation, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 3 3 3 | 6 3.0|
Congestion | 3 | 1 3.0|
Cyst | | 1 |
Degeneration, Fatty, Focal | 3 3 | 2 3.0|
Hyperplasia, Focal | | 3 2.3|
Vacuolization Cytoplasmic, Diffuse | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 3 3 | 4 2.5|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
Cyst, Multiple | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 3 4 3 4 4 3 2 3 4 3 3 4 | 26 3.4|
Pars Distalis, Cyst | X X X X X| 8 |
Pars Distalis, Cyst, Multiple | X | 5 |
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 3| 2 3.0|
Pars Distalis, Necrosis | | 1 2.0|
Pars Distalis, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia, Focal | 3 2 2 | 5 2.4|
C-Cell, Hyperplasia, Multifocal | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3| |
| 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + M + + + + + + + + + + M + + + +| 44 |
Inflammation, Suppurative | 4 3 | 2 3.5|
Duct, Cyst | X X X X X X| 12 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Chronic, Focal | 2 | 1 2.0|
Cervix, Cyst | X | 2 |
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Cyst | X | 1 |
Endometrium, Hyperplasia, Cystic | 3 3 2 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 9 |
Anemia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Congestion | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + M + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 4 3| 4 3.3|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3| |
| 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 4 4 | 5 3.0|
Hyperplasia, Lobular | 3 | 5 2.6|
Duct, Cyst | X X X X X X X X X X X X X X X X X X | 38 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4| 1 4.0|
Cranium, Hyperostosis | 2 2 X| 4 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 X X X | 6 3.7|
Degeneration, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 | 2 2.0|
Inflammation, Chronic | | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Foreign Body | | 1 3.0|
Lumen, Fungus | X | 2 |
Lumen, Inflammation, Suppurative | 3 4 | 4 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + | 11 |
Middle Ear, Inflammation, Suppurative| 4 | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3| |
| 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | | 1 1.0|
Nephropathy, Chronic | 3 3 2 2 2 3 2 3 2 3 3 1 3 1 2 3 2 2 4 3 2 3| 44 2.4|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | 3 | 1 3.0|
Renal Tubule, Degeneration | 3 | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|
| 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 2 2 2 2 2|
Clear Cell Focus | 2 |
Cytologic Alterations, Focal | 3 |
Developmental Malformation | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 2 2 |
Necrosis, Coagulative, Focal | |
Vacuolization Cytoplasmic, Diffuse | 4 3 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage, Focal | 3 |
Fat, Fibrosis, Focal | |
Fat, Necrosis, Focal | 2 3 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Acinus, Atrophy, Focal | 3 1 3 3|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Hyperkeratosis | |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|
| 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer, Focal | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia, Focal | 2 |
Erosion | 3 2 |
Mineralization | 2 |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 3 3 2 3 2 2 2 3 3 2 3 2 2 |
Inflammation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Degeneration, Fatty, Focal | 2 3 2 2 2|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + M + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 3 2 3 4 3 4 3 3 3 3 3 3|
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | X |
Pars Distalis, Hyperplasia, Focal | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | |
Follicle, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + M + + M + + M + + + M +|
Inflammation, Suppurative | |
Duct, Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|
| 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Cervix, Abscess | |
Cervix, Cyst | |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 |
Endometrium, Inflammation, | |
Suppurative | 2 |
Muscularis, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Anisocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | 3 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Axillary, Infiltration Cellular, | |
Plasma Cell | |
Axillary, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Erythrophagocytosis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + I + + +|
Erythrophagocytosis | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 3 3 |
Hemorrhage | 3 |
Necrosis, Coagulative | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + M M + + M + M + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 3 4 2 4 4 4 3 |
Hyperplasia, Lobular | 3 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|
| 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Degeneration, Multifocal | 3 |
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 3 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
Bronchiole, Inflammation, Chronic | |
Active | 3 |
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 |
Lumen, Fungus | X |
Lumen, Inflammation, Suppurative | 2 3 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + +|
Cataract | 3 |
Synechia | |
Cornea, Edema | 2 2|
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|
| 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 3 1 2 1 1 4 2 1 2 1 1 2 2 3 2 2 1 1 2 2 2 2|
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3| |
| 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | 2 2 2 2 2| 10 2.0|
Clear Cell Focus | | 1 2.0|
Cytologic Alterations, Focal | | 1 3.0|
Developmental Malformation | X| 1 |
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | | 2 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 2 2 | 7 2.0|
Necrosis, Coagulative, Focal | 3 1 | 2 2.0|
Vacuolization Cytoplasmic, Diffuse | | 2 3.5|
Vacuolization Cytoplasmic, Focal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 10 |
Hemorrhage, Focal | | 1 3.0|
Fat, Fibrosis, Focal | 3| 1 3.0|
Fat, Necrosis, Focal | 3 3 3| 8 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 3 2 2 2 | 8 2.4|
Acinus, Atrophy | | 1 2.0|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3| |
| 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 3.5|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Ulcer, Focal | | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia, Focal | | 1 2.0|
Erosion | | 2 2.5|
Mineralization | 3 2 | 3 2.3|
Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 3 2 2 2 2 3 3 3 3 2 2| 25 2.4|
Inflammation, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Degeneration, Fatty, Focal | 4 2| 7 2.4|
Hyperplasia, Focal | 2 2 2 3| 6 2.2|
Hypertrophy, Focal | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 2 3 4 3 4 4 4 3 3 4| 26 3.1|
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Cyst, Multiple | X X | 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3| |
| 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia, Multifocal | 2 2 | 2 2.0|
Follicle, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M M + + + + + + + + M + + + + + + + + +| 42 |
Inflammation, Suppurative | 2 | 1 2.0|
Duct, Cyst | X X X 4 | 7 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 | 2 3.0|
Cervix, Abscess | 3 4 | 2 3.5|
Cervix, Cyst | 4 | 1 4.0|
Cervix, Inflammation, Suppurative | 3 3 3 | 3 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 | 10 2.7|
Endometrium, Inflammation, | | |
Suppurative | | 1 2.0|
Muscularis, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 8 |
Anisocytosis | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2| 2 2.5|
Myelofibrosis | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Lymphoid | 3 | 1 3.0|
Axillary, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Axillary, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Mediastinal, Erythrophagocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3| |
| 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erythrophagocytosis | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Hematopoietic Cell Proliferation | 3 4 3 3 3 | 8 3.1|
Hemorrhage | | 1 3.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + M + + + + + M + + + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 3 3 | 11 3.5|
Hyperplasia, Lobular | 2 | 3 2.7|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X| 39 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | X X X | 5 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
Degeneration, Multifocal | 2 2 | 3 2.3|
Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Congestion | 2 2| 4 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 1 1 | 5 1.8|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3| |
| 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal | | 1 3.0|
Bronchiole, Inflammation, Chronic | | |
Active | | 1 3.0|
Bronchiole, Inflammation, Suppurative| 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + M M + + + + + + + + M + + + + + + + + +| 47 |
Lumen, Foreign Body | | 1 2.0|
Lumen, Fungus | | 1 |
Lumen, Inflammation, Suppurative | | 3 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 5 |
__________________________________________________________________________|____________|
Eye | + + | 6 |
Cataract | 4 | 2 3.5|
Synechia | 4 | 1 4.0|
Cornea, Edema | | 2 2.0|
Retina, Degeneration | 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 1 3 3 3 2 1 2 2 3 1 3 2 4 2 1 2 3 3 1 3 1 2 2| 48 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|
| 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.06% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | M + + + + M + + + + A + + + + + + + + + + A + + +|
Parasite Metazoan | X |
Mucosa, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 2 2 |
Developmental Malformation | X X X |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Granulomatous, | |
Multifocal | 3 2 |
Necrosis, Coagulative, Diffuse | |
Vacuolization Cytoplasmic, Diffuse | 3 3 4 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 3 |
Bile Duct, Hyperplasia | 3 2 2 3 2 |
Centrilobular, Congestion | 2 |
Kupffer Cell, Pigmentation, Bile | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Focal, Granulomatous | 3 |
Fat, Necrosis, Focal | 3 3 3 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Acinus, Atrophy, Focal | 3 3 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | X |
Edema | 4 |
Hyperkeratosis | |
Hyperplasia | |
Inflammation, Chronic | |
Mineralization | |
Ulcer, Focal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|
| 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.06% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 4 |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 2 2 3 3 2 2 3 4 2 2 3 3 2 2 3 3 3 3 3|
Inflammation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis | 3 4 4 |
Degeneration, Fatty, Focal | 3 |
Hemorrhage, Diffuse | |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 2 2 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis | |
Hyperplasia, Focal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 3 2 3 4 4 3 4 4 3|
Pars Distalis, Cyst | X X X |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 3 2 2 1 3 2 2 |
C-Cell, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + + + + + + + + M + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|
| 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.06% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 3 |
Duct, Cyst | X X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Cervix, Abscess | 3 3 |
Cervix, Cyst | X X X |
Cervix, Cyst, Multiple | |
Cervix, Inflammation, Suppurative | 2 3 |
Endometrium, Hyperplasia, Cystic | 4 2 3 2 3|
Endometrium, Inflammation, | |
Suppurative | 2 |
Endometrium, Necrosis, Focal | |
Lumen, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + A + + +|
Myelofibrosis | 3 |
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | |
Renal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | |
Congestion | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Focal, Lymphoid | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | M M + + M M + + M M M M + + + + + M + M + M + + M|
Congestion | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|
| 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.06% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 3 3 4 3 3 4 4|
Hyperplasia, Lobular | 3 2 2 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | 3 3 |
Hyperplasia, Focal | 3 |
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 X 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration, Multifocal | |
Hemorrhage, Focal | 2 |
Hemorrhage, Multifocal | |
Hydrocephalus | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Edema | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Edema | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Lumen, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|
| 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.06% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + + + + + + + + + +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + |
Cataract | 4 4 3 3 3 3 3 3 2 3 4 3 2 2 3 3 |
Inflammation, Suppurative | |
Lens, Mineralization | 3 3 |
Retina, Degeneration | 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
Fibrosis | 3 4 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | |
Nephropathy, Chronic | 2 2 3 4 1 2 2 3 2 2 2 2 1 1 3 3 3 3 2 2 2 2 3|
Pigmentation, Hemosiderin | 3 |
Cortex, Fibrosis, Focal | 3 |
Pelvis, Hydronephrosis | |
Renal Tubule, Degeneration | 3 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X | 3 |
Mucosa, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 | 8 2.0|
Developmental Malformation | X | 4 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 3 2 2 | 5 2.4|
Necrosis, Coagulative, Diffuse | 4 | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | 4 4 | 5 3.6|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| 3 | 2 3.0|
Bile Duct, Hyperplasia | 2 2 | 7 2.3|
Centrilobular, Congestion | | 1 2.0|
Kupffer Cell, Pigmentation, Bile | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Focal, Granulomatous | | 1 3.0|
Fat, Necrosis, Focal | 3 | 7 3.1|
__________________________________________________________________________|____________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy, Focal | 2 3 4 | 5 3.0|
Acinus, Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + I + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + I + + + +| 48 |
Cyst | | 1 |
Edema | 4 4 | 3 4.0|
Hyperkeratosis | 3 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 3 3 | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Ulcer, Focal | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + I + + + +| 48 |
Inflammation, Chronic | | 1 4.0|
Mineralization | 2 | 2 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 2 3 2 2 2 2 3 3 3 2 3 2 3 2| 34 2.5|
Inflammation, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 4 | 5 3.8|
Degeneration, Fatty, Focal | 2 2 4 2 | 5 2.6|
Hemorrhage, Diffuse | 4 | 1 4.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal | | 3 2.0|
Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
Hyperplasia, Focal | 3 | 2 2.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 3 3 4 4 3 4 3 2 4 3 3 3 2| 24 3.3|
Pars Distalis, Cyst | X X X X X | 8 |
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | X X X | 3 |
C-Cell, Hyperplasia, Focal | 2 2 | 9 2.1|
C-Cell, Hyperplasia, Multifocal | 2 2 3 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 3 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M M M + + M M + M + + + + + + M + + M + + + +| 38 |
Inflammation, Suppurative | 3 4 4 | 5 3.4|
Duct, Cyst | 4 X X X X X X X X| 13 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 2 | 2 2.0|
Cervix, Abscess | 3 4 | 4 3.3|
Cervix, Cyst | X X | 5 |
Cervix, Cyst, Multiple | X | 1 |
Cervix, Inflammation, Suppurative | 2 2 | 4 2.3|
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 | 10 2.8|
Endometrium, Inflammation, | | |
Suppurative | 2 | 2 2.0|
Endometrium, Necrosis, Focal | 3 | 1 3.0|
Lumen, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Myelofibrosis | 4 | 2 3.5|
Myeloid Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Congestion | 4 | 1 4.0|
Renal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Congestion | 3 3 3 | 4 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 | 6 2.8|
Hyperplasia, Focal, Lymphoid | 4 | 2 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + M + + + + + + + M + + + + + + + + + M + +| 34 |
Congestion | 4 | 1 4.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 3 4 3 3 3 3 3 4| 20 3.3|
Hyperplasia, Lobular | 3 3 | 5 2.6|
Duct, Cyst | X X X X X X X X X X X X X X | 33 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis, Focal | | 2 3.0|
Hyperplasia, Focal | | 1 3.0|
Subcutaneous Tissue, Cyst | X | 1 |
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 2 3.0|
Degeneration, Multifocal | 2 | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
Hydrocephalus | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 4 2.3|
Edema | 4 | 1 4.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 2 | 2 2.5|
Inflammation, Chronic | 2 4 | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1| 1 1.0|
Interstitium, Edema | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Lumen, Foreign Body | 3 | 1 3.0|
Lumen, Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Eye | + + | 19 |
Cataract | | 16 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Lens, Mineralization | | 2 3.0|
Retina, Degeneration | | 17 3.1|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + | 9 |
Fibrosis | 3 3 4 3 4 | 8 3.4|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | 2 | 1 2.0|
Nephropathy, Chronic | 1 2 2 2 1 4 2 1 2 2 1 4 2 1 2 2 3| 40 2.2|
Pigmentation, Hemosiderin | | 1 3.0|
Cortex, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3| |
| 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.06% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Hydronephrosis | 2 | 1 2.0|
Renal Tubule, Degeneration | | 2 3.0|
Renal Tubule, Hyperplasia, Focal | 2 | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|
| 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 |
Cytologic Alterations, Focal | 3 3 |
Cytologic Alterations, Multifocal | 3 |
Degeneration, Cystic, Focal | 3 |
Hyperplasia, Nodular | 3 |
Necrosis, Coagulative, Multifocal | 3 3 3 |
Vacuolization Cytoplasmic, Diffuse | 4 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia | 3 2 3 3 3 2 |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Degeneration | 3 |
Portal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Fat, Edema | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 4 2 4 3 2 |
Adventitia, Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + I + + + + + +|
Edema | 4 |
Necrosis | |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + I + + + + + +|
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|
| 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 3 3 3 3 3 2 3 2 3 3 2 2 2 3 2 3 2 2 3 3 3|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hyperplasia, Focal | 3 3 |
Necrosis, Multifocal | 4 |
Vacuolization Cytoplasmic, Focal | 3 3 4 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 3 3 3 3 3 2|
Hyperplasia, Multifocal | |
Mineralization | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 3 4 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2|
C-Cell, Hyperplasia, Multifocal | |
Follicle, Cyst | |
Follicle, Cyst, Multiple | |
Follicle, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 2 3 3 2 4 3 3 4 3 4 3 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + M + +|
Atrophy | 3 |
Fibrosis | 4 3 3 3 |
Hyperplasia | |
Inflammation, Suppurative | 3 3 3 3 |
Duct, Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|
| 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 4 2 3 3 3 1 2 3 3 1 3 3|
Mineralization, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermatogenesis | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrophy | 3 3 3 3 3 4 4 3 3 3 4 3 3 4 4 3 3 4 3 4 3|
Hemorrhage | 3 |
Mineralization | 3 |
Arteriole, Necrosis, Fibrinoid | 2|
Interstitial Cell, Hyperplasia | 3 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + M + + + |
Hypochromasia | X |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | 3|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
Mediastinal, Pigmentation, | |
Hemosiderin | 4 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M M + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + M + M M + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|
| 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Duct, Cyst | X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X X |
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cerebellum, Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 3 |
Congestion | 3 |
Hemorrhage, Multifocal | 2 |
Infiltration Cellular, Histiocyte | 2 |
Arteriole, Hypertrophy | 3 |
Interstitium, Infiltration Cellular, | |
Diffuse, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | X 2 |
Lumen, Inflammation, Suppurative | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + + + + +|
__________________________________________________________________________|
Eye | + + + +|
Cataract | 2 |
Retina, Degeneration | 3 2|
__________________________________________________________________________|
Harderian Gland | + |
Fibrosis | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
Atrophy | 2 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|
| 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 4 3 3 2 3 4 4 4 2 2 3 2 3 2 3 3 4 3 2 3 3 4 3|
Cortex, Cyst | X |
Cortex, Necrosis | 3 |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3| |
| 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
Submucosa, Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | | 1 2.0|
Cytologic Alterations, Focal | 3 2 3 | 5 2.8|
Cytologic Alterations, Multifocal | | 1 3.0|
Degeneration, Cystic, Focal | 4 2 2 | 4 2.8|
Hyperplasia, Nodular | | 1 3.0|
Necrosis, Coagulative, Multifocal | | 3 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 2 3 3 | 3 2.7|
Vacuolization Cytoplasmic, Multifocal| 2 | 2 2.0|
Bile Duct, Hyperplasia | 3 3 3 3| 10 2.8|
Bile Duct, Hyperplasia, Multifocal | 2 | 1 2.0|
Centrilobular, Degeneration | | 1 3.0|
Portal, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Inflammation, Granulomatous | 3 | 1 3.0|
Fat, Edema | 3 | 1 3.0|
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 3 2 | 9 2.9|
Adventitia, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 4 | 2 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3| |
| 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 3 3 2 3 4 3 3 3 3 3 3 3 3 3 2 3 3 3 2 3 3 3 3| 44 2.8|
Atrium, Thrombosis | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Cyst | X | 1 |
Hyperplasia, Focal | 2 | 3 2.7|
Necrosis, Multifocal | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 3 2 3 3 2 2 | 11 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 3 3 | 10 2.9|
Hyperplasia, Multifocal | 3 | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 4 | 9 3.1|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 3 2 | 6 2.2|
C-Cell, Hyperplasia, Multifocal | 3 | 1 3.0|
Follicle, Cyst | X| 1 |
Follicle, Cyst, Multiple | X | 1 |
Follicle, Hyperplasia, Cystic | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3| |
| 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 4 3 4 3 4 4 4 4 3 4 3 4 3 3 4 4 4 4 3 4| 40 3.6|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
Fibrosis | 3 3 3 | 7 3.1|
Hyperplasia | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 3 3 3 3 2 | 11 2.9|
Duct, Cyst | X X X X X X| 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | 2 2 | 3 2.0|
Inflammation, Suppurative | 3 1 3 2 3 1 1 3 4 1 4 | 24 2.5|
Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aspermatogenesis | 4 2 2 2 2 2 2 4 2 2 2 3 3 3 3 3 3 3 3 3| 38 2.3|
Atrophy | 3 4 4 4 4 4 3 3 4 4 4 4 3 3 4 3 3 4 3 4| 41 3.5|
Hemorrhage | | 1 3.0|
Mineralization | | 1 3.0|
Arteriole, Necrosis, Fibrinoid | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 2 2 | 4 2.5|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + | 18 |
Hypochromasia | | 1 |
Polychromasia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 3 | 2 3.0|
Myelofibrosis | | 1 3.0|
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Congestion | 4 | 1 4.0|
Mediastinal, Pigmentation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3| |
| 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemosiderin | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + M + + + +| 46 |
Cyst | | 1 |
Hyperplasia, Lymphoid | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Angiectasis | 3 4 3 | 3 3.3|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 1 3.0|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + M + M + + M M + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + M + + M + + + + + + + + +| 46 |
Duct, Cyst | X X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | | 2 |
Cyst Epithelial Inclusion | X X | 2 |
Hyperkeratosis, Focal | 3 2 | 2 2.5|
Prepuce, Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 1 3.0|
Cerebellum, Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | | 1 3.0|
Congestion | 2 | 2 2.5|
Hemorrhage, Multifocal | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 3 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3| |
| 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Arteriole, Hypertrophy | | 1 3.0|
Interstitium, Infiltration Cellular, | | |
Diffuse, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Fungus | | 2 2.0|
Lumen, Inflammation, Suppurative | 3 | 3 2.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 2.0|
Retina, Degeneration | | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Atrophy | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 4 4 3 4 3 4 4 2 3 4 4 4 4 1 3 2 3 3 2 4 4 3 3| 50 3.1|
Cortex, Cyst | X | 2 |
Cortex, Necrosis | | 1 3.0|
Renal Tubule, Hyperplasia, Focal | 2 | 2 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X X |
Submucosa, Edema | 4 3 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | M A + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + M + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X|
Cytologic Alterations, Focal | 3 2|
Cytologic Alterations, Multifocal | 3 |
Degeneration, Cystic, Focal | 3 |
Developmental Malformation | |
Hyperplasia, Nodular | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Granulomatous, | |
Multifocal | 3 3 |
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | 2 3 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 3 3 3 2 3 2 2 3 3 |
Serosa, Fibrosis, Focal | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis, Focal | 4 |
Pigmentation, Hematoidin, Hemosiderin| 3 |
Artery, Inflammation, Chronic | |
Artery, Mineralization | 3 |
Artery, Thrombosis | X |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Pigmentation, Hematoidin, Hemosiderin| 3 |
Acinus, Atrophy | 2 2 1 3 4 3 |
Adventitia, Edema | 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mineralization | 2 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Mineralization | 3 3 2 2 1 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 3 3 3 4 3 3 2 3 3 2 2 2 2 3 3 3 3 3 2 3|
Inflammation, Suppurative | |
Atrium, Thrombosis | X |
Valve, Bacterium | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Vacuolization Cytoplasmic, Focal | 3 3 3 2 2 2 2 2 2|
Vacuolization Cytoplasmic, Multifocal| 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 3 4 4 3 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 4 3 3 4 3 3 2|
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Necrosis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X X X X X X |
Degeneration | |
Depletion Cellular | 4 3 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 3 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Cyst, Multiple | |
Inflammation, Suppurative | 3 2 3 3 3 3 4 3 3 2 2 3 3 4 3 1 3 3 3 |
Mineralization, Multifocal | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 2 3 |
Dilatation | |
Epithelium, Hyperplasia | 2 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermatogenesis | 3 3 4 4 4 4 4 4 4 4 4 3 3 3 4 4 3 3 4 4 |
Atrophy | 3 3 4 4 4 4 4 4 3 2 4 3 3 4 4 2 4 4 4 4 4 4 4 4 3|
Degeneration | 3 4 4 4 4 4 4 3 4 3 3 3 3 4 3 3 3 4 |
Arteriole, Necrosis, Fibrinoid | 3 4 3 3 2 3 2 3 |
Interstitial Cell, Hyperplasia | 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 3 3 3 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Polychromasia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, | |
Granulomatous | 3 |
Pancreatic, Mineralization | 2 |
Renal, Angiectasis | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | X |
Hyperplasia, Lymphoid | 3 3 3 3 |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 4 4 |
Hyperplasia, Lymphoid | 3 3 2 |
Mineralization | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Fibrosis, Diffuse | |
Fibrosis, Focal | 3 4 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + M + M M M M + + + M + + + + M + +|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M M + + + + + + + + + + + + + +|
Duct, Cyst | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Hyperkeratosis, Focal | 3 3 |
Hyperplasia, Focal | 3 |
Inflammation, Chronic | 3 |
Ulcer, Focal | |
Subcutaneous Tissue, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X 4 X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cerebellum, Hemorrhage, Acute, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 |
Congestion | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Edema | |
Interstitium, Infiltration Cellular, | |
Mononuclear Cell | 2 |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + + + + + + + + +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + +|
Cataract | 3 3 3 3 3 3 3 3 2 3 3 3 3 3|
Anterior Chamber, Hemorrhage | 3 |
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation, Focal, | |
Granulomatous | |
Lens, Mineralization | 3 4|
Retina, Degeneration | 4 3 3 3 3 3 3 3 3 3 3 4 3 3|
__________________________________________________________________________|
Harderian Gland | + + + + |
Atrophy | 3 |
Fibrosis | 3 3 3 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial, Multifocal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Suppurative | |
Mineralization | 4 2 |
Nephropathy, Chronic | 3 3 4 4 4 4 4 4 4 3 4 3 4 4 4 1 4 3 4 4 4 3 4 4 3|
Cortex, Cyst | X |
Cortex, Cyst, Multiple | |
Medulla, Congestion | |
Pelvis, Hydronephrosis | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Ureter | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|
| 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 2 |
Submucosa, Edema | 3 | 3 3.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 |
Cytologic Alterations, Focal | 2 2 | 4 2.3|
Cytologic Alterations, Multifocal | 2 | 2 2.5|
Degeneration, Cystic, Focal | 2 | 2 2.5|
Developmental Malformation | X | 1 |
Hyperplasia, Nodular | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 3 3 | 4 3.0|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative, Multifocal | 3 | 3 2.7|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 3 3 2 3 2 3 3 2 3 2 2| 21 2.6|
Serosa, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fibrosis, Focal | | 1 4.0|
Pigmentation, Hematoidin, Hemosiderin| | 1 3.0|
Artery, Inflammation, Chronic | 4 | 1 4.0|
Artery, Mineralization | | 1 3.0|
Artery, Thrombosis | | 1 |
Fat, Necrosis, Focal | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pigmentation, Hematoidin, Hemosiderin| | 1 3.0|
Acinus, Atrophy | 2 3 3 3 2 2 2 2 2 | 15 2.4|
Adventitia, Edema | | 1 3.0|
Artery, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 4 | 2 3.5|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 2 2| 3 2.0|
Ulcer, Focal | 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Mineralization | 3 3 1 3 1 3 | 14 2.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 39 2.8|
Inflammation, Suppurative | 4 | 1 4.0|
Atrium, Thrombosis | 3 | 2 3.0|
Valve, Bacterium | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 2 3 3 3 3 2| 15 2.5|
Vacuolization Cytoplasmic, Multifocal| | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hyperplasia, Focal | 2 3 2 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 2 4 3 3 3 2 3 3 3| 23 3.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 4 4 3 | 14 3.2|
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst, Multiple | | 2 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 1 2 | 5 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Pars Distalis, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X X | 2 |
C-Cell, Hyperplasia, Focal | 2 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 12 |
Degeneration | 4 | 1 4.0|
Depletion Cellular | 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4| 46 3.9|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + M + + + + + + + + + + + + + +| 47 |
Fibrosis | | 5 3.0|
Duct, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Cyst | X| 2 |
Cyst, Multiple | X X X | 3 |
Inflammation, Suppurative | 2 3 3 3 3 4 3 3 2 3 3 3 2 2 3 2 2 3 2 3| 39 2.8|
Mineralization, Multifocal | | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 | 8 2.8|
Dilatation | 3| 1 3.0|
Epithelium, Hyperplasia | | 4 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aspermatogenesis | 4 4 4 4 3 3 4 4 4 3 3 3 4 4 4 4 3 4 3 3 3 3 4 4| 44 3.6|
Atrophy | 4 4 4 4 3 3 4 4 4 4 3 3 4 4 4 4 4 3 3 3 4 4 4| 48 3.6|
Degeneration | 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 36 3.3|
Arteriole, Necrosis, Fibrinoid | 2 3 2 3 2 3 3 | 15 2.7|
Interstitial Cell, Hyperplasia | 3 | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 3 3 3 3 2 3 3 3 3 3| 19 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + M + + + + + | 10 |
Polychromasia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Myelofibrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Angiectasis | 3 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
Pancreatic, Mineralization | | 1 2.0|
Renal, Angiectasis | 3 4 3 | 4 3.3|
Renal, Hyperplasia, Lymphoid | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + M + + +| 47 |
Angiectasis | | 1 3.0|
Cyst | | 1 |
Hyperplasia, Lymphoid | 4 3 3 3 3 4 | 10 3.2|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 3 3.7|
Hyperplasia, Lymphoid | 3 | 4 2.8|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 4 2.8|
Fibrosis, Diffuse | 3 | 1 3.0|
Fibrosis, Focal | 4 3 3 2 | 6 3.2|
Hematopoietic Cell Proliferation | 3 | 2 3.5|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + M M + M M + + + M + + M +| 34 |
Artery, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
Duct, Cyst | X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 3.0|
Hyperkeratosis, Focal | | 2 3.0|
Hyperplasia, Focal | 4 | 2 3.5|
Inflammation, Chronic | 4 | 2 3.5|
Ulcer, Focal | 4 | 1 4.0|
Subcutaneous Tissue, Necrosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 5 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 X | 2 3.0|
Cerebellum, Hemorrhage, Acute, | | |
Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | 3 | 2 2.5|
Congestion | 2 2| 3 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Infiltration Cellular, Histiocyte | 3 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 | 3 2.3|
Alveolus, Edema | 4 | 1 4.0|
Interstitium, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Lumen, Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Eye | + + + + + + + +| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| |
| 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 14 2.9|
Anterior Chamber, Hemorrhage | | 1 3.0|
Anterior Chamber, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Cornea, Inflammation, Focal, | | |
Granulomatous | 3 | 1 3.0|
Lens, Mineralization | | 2 3.5|
Retina, Degeneration | 1 2 2 | 17 2.9|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
Atrophy | | 1 3.0|
Fibrosis | | 4 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial, Multifocal | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 2 | 3 2.7|
Nephropathy, Chronic | 4 4 4 3 4 2 3 4 4 4 4 3 4 4 3 4 4 3 1 2 3 4 4| 48 3.5|
Cortex, Cyst | X | 2 |
Cortex, Cyst, Multiple | X | 1 |
Medulla, Congestion | 3 | 1 3.0|
Pelvis, Hydronephrosis | 3 3 | 2 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 3 | 2 3.0|
Renal Tubule, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Edema | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Congestion | 3 |
Cytologic Alterations, Focal | 2 2 3 2 |
Cytologic Alterations, Multifocal | 2 2 |
Degeneration, Cystic, Focal | 2 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 3 2 3 2 2 2 |
Portal, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Artery, Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 3 3 2|
Vein, Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 2 2 2 2 2 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Fibrosis, Multifocal | 3 3 3 2 2 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 2 2 3 3 2|
Mineralization, Multifocal | 3 |
Atrium, Thrombosis | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 3 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 3 4 3 2 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Focal | 1 2 2 |
Hyperplasia, Multifocal | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 4 4 3 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Nervosa, Infiltration Cellular | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia, Focal | 2 2 |
C-Cell, Hyperplasia, Multifocal | |
Follicle, Cyst | X |
Follicle, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 4 4 3 3 4 3 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3|
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 3 2 2 4 |
Duct, Cyst | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | 3 3 3 3 |
Inflammation, Chronic | 1 |
Inflammation | 2 |
Inflammation, Suppurative | 3 1 2 4 4 2 3 2 1 3 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermatogenesis | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrophy | 3 4 4 3 2 4 2 3 3 4 4 4 4 2 2 4 3 4 3 4 3 4 |
Arteriole, Necrosis, Fibrinoid | 2 2 2 2 2 |
Interstitial Cell, Hyperplasia | 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M + + + +|
Anemia | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Ectasia | 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + M + M + + + + + + + + + + + M + M + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis, Focal | |
Hyperplasia, Focal | |
Ulcer, Focal | |
Subcutaneous Tissue, Mineralization, | |
Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Cerebellum, Degeneration | |
Cerebellum, Hemorrhage, Focal | 4 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 |
Alveolus, Edema | |
Alveolus, Mineralization, Multifocal | 3 |
Bronchiole, Foreign Body | |
Interstitium, Edema | |
Mediastinum, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.13% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemosiderin | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 3|
Lumen, Inflammation, Suppurative | 3|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
Cornea, Infiltration Cellular, | |
Lymphocyte | |
Cornea, Mineralization | |
__________________________________________________________________________|
Harderian Gland | + + |
Ectasia | 2 |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 |
Mineralization | 3 2 |
Nephropathy, Chronic | 4 3 4 3 3 3 4 4 4 3 3 3 3 3 3 4 3 3 3 4 4 3 3 3 |
Cortex, Cyst | X |
Cortex, Cyst, Multiple | X X |
Pelvis, Hydronephrosis | 3 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 3 |
Renal Tubule, Hyperplasia, Focal | 2|
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 3 |
Mucosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Submucosa, Edema | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Congestion | 3 | 2 3.0|
Cytologic Alterations, Focal | 2 | 5 2.2|
Cytologic Alterations, Multifocal | | 2 2.0|
Degeneration, Cystic, Focal | 2 | 2 2.0|
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 3 2 | 3 2.3|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 2 3 2 2 2 1 3| 15 2.3|
Portal, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Artery, Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis, Focal | 3 | 5 2.8|
Vein, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 2 | 10 2.3|
Artery, Inflammation, Chronic | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 4 3 | 3 3.3|
Mineralization | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 3 3 3 2 2 | 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 2 2 3 2 3 3 3 3 2 3 2 2 3 2 2 3 2 3 3 | 45 2.7|
Mineralization, Multifocal | | 1 3.0|
Atrium, Thrombosis | X | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hyperplasia, Focal | 2 2 | 2 2.0|
Hypertrophy, Focal | 3 | 2 3.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 | 6 2.7|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 3 2 2 3 3| 8 2.3|
Hyperplasia, Multifocal | 3 | 2 2.5|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + M + + +| 47 |
Hyperplasia | 2 3 2 3 4 3 3 2 3 3 4 4 | 18 3.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 7 3.1|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 6 2.0|
Pars Nervosa, Infiltration Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia, Focal | | 2 2.0|
C-Cell, Hyperplasia, Multifocal | 4 | 1 4.0|
Follicle, Cyst | | 1 |
Follicle, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 43 3.8|
Fibrosis | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 | 3 3.0|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 4 | 6 2.8|
Duct, Cyst | X X X X X X X X X X| 13 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Fibrosis | | 4 3.0|
Inflammation, Chronic | 2 | 2 1.5|
Inflammation | | 1 2.0|
Inflammation, Suppurative | 4 2 3 3 3 3 3 3| 19 2.7|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 4 3 3 3 | 8 3.1|
Fibrosis | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aspermatogenesis | 2 2 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.1|
Atrophy | 2 3 3 4 3 3 4 4 3 3 4 4 2 3 4 4 4 4 4 4 4 3| 44 3.4|
Arteriole, Necrosis, Fibrinoid | 1 2 2 | 8 1.9|
Interstitial Cell, Hyperplasia | 2 3 | 3 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + +| 13 |
Anemia | X | 1 |
Polychromasia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3| 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Cyst | | 1 |
Hyperplasia, Lymphoid | 3 3| 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Ectasia | 4 | 2 2.5|
Hyperplasia, Lymphoid | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 2 | 4 2.8|
Fibrosis, Focal | 4 | 2 3.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + M + M + + + + + M M + + + M + + M + M + +| 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Duct, Cyst | X X X | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 3 |
Fibrosis, Focal | 3 4 3 | 3 3.3|
Hyperplasia, Focal | 4 | 1 4.0|
Ulcer, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Mineralization, | | |
Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 3 | 5 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 3.0|
Cerebellum, Degeneration | 3 | 1 3.0|
Cerebellum, Hemorrhage, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 2 3 2 2 | 8 1.9|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 4.0|
Alveolus, Edema | 3 | 1 3.0|
Alveolus, Mineralization, Multifocal | | 1 3.0|
Bronchiole, Foreign Body | 2 | 1 2.0|
Interstitium, Edema | 2 | 1 2.0|
Mediastinum, Pigmentation, | | |
Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Foreign Body | | 1 3.0|
Lumen, Inflammation, Suppurative | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 3| 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Eye | + + + + +| 6 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
Cornea, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
Cornea, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
Ectasia | 3 | 2 2.5|
Fibrosis | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05051-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROFURANTOIN Date: 05/06/97
Route: DOSED FEED Time: 13:25:52
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3| |
| 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.13% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 2.5|
Nephropathy, Chronic | 3 4 3 4 1 2 2 3 4 4 4 4 4 4 2 3 3 3 3 4 3 4 4 3| 48 3.3|
Cortex, Cyst | X | 2 |
Cortex, Cyst, Multiple | X | 3 |
Pelvis, Hydronephrosis | 3 2 3 | 5 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 3 | 5 2.4|
Renal Tubule, Hyperplasia, Focal | 2 | 2 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | | 1 3.0|
Mucosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
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