TR 341 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05051 NITROFURANTOIN TIME: 07:15:02
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55196
CONT: NOIES28024 CAS: 67-20-9
PATHOLOGIST: R. THOMPSON
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05051 NITROFURANTOIN TIME: 07:15:02
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55196
CONT: NOIES28024 CAS: 67-20-9
PATHOLOGIST: R. THOMPSON
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 387 455 506 533 554 559 579 591 591 601 |
| 621 621 630 633 643 645 653 659 677 678 |
| 695 715 723 729 729 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.13% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 320 483 489 548 561 601 602 630 644 656 |
| 671 679 687 699 700 708 712 720 722 726 |
| 727 728 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 386 387 413 493 532 559 619 632 633 635 |
| 636 639 646 670 670 697 699 705 709 715 |
| 716 719 728 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 80.0 64.0 48.0 |
|CONTROL | |
| | |
|0.13% | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 86.0 80.0 54.0 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 94.0 94.0 90.0 88.0 74.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.13% 0.25% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 54.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.668N P=0.512N P=0.732N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.6 640.9 623.6 |
|NATURAL DEATHS (C) | (16.9) (21.5) (21.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.1 689.0 678.9 |
|(STANDARD ERROR) | (11.7) (11.6) (12.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 428 481 510 568 602 620 633 649 658 661 |
| 666 671 673 691 700 701 702 709 719 720 |
| 727 727 728 729 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.06% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 390 423 435 456 491 498 554 564 567 601 |
| 621 633 653 665 665 670 687 714 715 720 |
| 726 727 728 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.13% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 394 412 448 448 491 513 554 598 624 646 |
| 675 677 678 686 693 699 700 700 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROFURANTOIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 80.0 50.0 |
|CONTROL | |
| | |
|0.06% | 100.0 100.0 100.0 100.0 96.0 92.0 88.0 80.0 70.0 52.0 |
| | |
| | |
|0.13% | 100.0 100.0 100.0 100.0 96.0 92.0 88.0 84.0 80.0 62.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.06% 0.13% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 52.0% 62.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.446N P=1.000 P=0.489N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 656.1 609.6 596.9 |
|NATURAL DEATHS (C) | (16.4) (22.5) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.0 672.2 679.4 |
|(STANDARD ERROR) | ( 9.7) (13.7) (13.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROFURANTOIN
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.13% = 2
0.25% = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 1 1 2
| 3 3 1 223 1 1 2
| 3 31 212
P 90 + 3 32 2
E | 1 1 3
R | 1 12 3232
C | 11 2 2
E 80 + 1 1 2 2
N | 33 22
T | 11133 32 22
| 11
S 70 + 11 3 2 2
U | 11
R | 1 1 1 33222
V | 33
I 60 + 1 1
V | 1 1
A | 11 1
L | 3 3
50 +
| 1
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
NITROFURANTOIN
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.06% = 2
0.13% = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 23 1
|
| 23 3 21 1
| 3 2 23 1 1
95 +
| 2 2 1 1
| 3 2 2 1 1
|
90 + 22 3 1 1
|
| 2 3 2 1 1
| 22 3 1 1
P 85 +
E | 3 3 11
R | 2 2 3 31 1
C |
E 80 + 2 2 3 113
N |
T | 2 2
| 2 2 11
S 75 +
U | 2 2 131
R | 311
V |
I 70 + 22 311
V |
A | 2 2
L | 2 11
65 +
| 3311
| 3 3
|
60 + 11
|
|
|
55 +
| 1 1
| 2 2
|
50 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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