TR 346 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 02 TIME: 14:19:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. BUSCH CAS: 75-00-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 02 TIME: 14:19:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. BUSCH CAS: 75-00-3
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 02 TIME: 14:19:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. BUSCH CAS: 75-00-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ETHYL CHLORIDE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Carcinoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/47 (0%) | 1/49 (2%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 3.1% 5.4% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) | 1/32 (3%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 700 (T) 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.231 |
|INCIDENTAL TUMOR | (e) (e) | P=0.823 |
|LOGISTIC REGRESSION | (e) (e) | P=0.499 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.484 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) | 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 36.4% | 6.3% 0.0% |
|TERMINAL (d) | 2/28 (7%) 4/11 (36%) | 2/32 (6%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 700 (T) 700 (T) | 700 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * | P=0.878N |
|INCIDENTAL TUMOR | P=0.039 * | P=0.878N |
|LOGISTIC REGRESSION | P=0.039 * | P=0.878N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.339 | P=0.242N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) | 0/49 (0%) 2/50 (4%) |
|ADJUSTED (b) | 5.5% 0.0% | 0.0% 5.6% |
|TERMINAL (d) | 1/28 (4%) 0/11 (0%) | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 --- | --- 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.391N | P=0.191 |
|INCIDENTAL TUMOR | P=0.269N | P=0.848 |
|LOGISTIC REGRESSION | P=0.207N | P=0.256 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247N | P=0.253 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) | 2/49 (4%) 2/50 (4%) |
|ADJUSTED (b) | 12.5% 36.4% | 6.3% 5.6% |
|TERMINAL (d) | 3/28 (11%) 4/11 (36%) | 2/32 (6%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 700 (T) | 700 (T) 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.174 | P=0.261 |
|INCIDENTAL TUMOR | P=0.226 | P=0.841 |
|LOGISTIC REGRESSION | P=0.264 | P=0.689 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.643N | P=0.684N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/47 (4%) | 0/49 (0%) 1/48 (2%) |
|ADJUSTED (b) | 18.7% 12.9% | 0.0% 2.9% |
|TERMINAL (d) | 4/28 (14%) 1/11 (9%) | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 519 | --- 590 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.511N | P=0.449 |
|INCIDENTAL TUMOR | P=0.360N | P=0.948 |
|LOGISTIC REGRESSION | P=0.315N | P=0.510 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.155N | P=0.495 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 9/47 (19%) | 3/49 (6%) 7/48 (15%) |
|ADJUSTED (b) | 22.6% 52.6% | 9.4% 47.7% |
|TERMINAL (d) | 2/28 (7%) 5/11 (45%) | 3/32 (9%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 479 357 | 700 (T) 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.489 | P=0.130 |
|LOGISTIC REGRESSION | P=0.480 | P=0.025 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.545 | P=0.150 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 10/47 (21%) | 3/49 (6%) 8/48 (17%) |
|ADJUSTED (b) | 37.9% 54.6% | 9.4% 49.2% |
|TERMINAL (d) | 6/28 (21%) 5/11 (45%) | 3/32 (9%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 357 | 700 (T) 590 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.377N | P=0.121 |
|LOGISTIC REGRESSION | P=0.352N | P=0.025 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.227N | P=0.093 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 10/47 (21%) | 3/49 (6%) 8/48 (17%) |
|ADJUSTED (b) | 37.9% 54.6% | 9.4% 49.2% |
|TERMINAL (d) | 6/28 (21%) 5/11 (45%) | 3/32 (9%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 357 | 700 (T) 590 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.377N | P=0.121 |
|LOGISTIC REGRESSION | P=0.352N | P=0.025 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.227N | P=0.093 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 8/48 (17%) | 2/49 (4%) 2/50 (4%) |
|ADJUSTED (b) | 10.7% 43.5% | 6.3% 18.3% |
|TERMINAL (d) | 3/28 (11%) 3/11 (27%) | 2/32 (6%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 700 (T) 409 | 700 (T) 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** | P=0.078 |
|INCIDENTAL TUMOR | P=0.020 * | P=0.382 |
|LOGISTIC REGRESSION | P=0.016 * | P=0.354 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.087 | P=0.684N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/48 (4%) | 3/49 (6%) 2/50 (4%) |
|ADJUSTED (b) | 7.1% 16.1% | 8.9% 51.9% |
|TERMINAL (d) | 2/28 (7%) 1/11 (9%) | 2/32 (6%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 700 (T) 671 | 688 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.349 | P=0.112 |
|INCIDENTAL TUMOR | P=0.338 | P=0.607 |
|LOGISTIC REGRESSION | P=0.358 | P=0.479 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.676 | P=0.490N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 10/48 (21%) | 5/49 (10%) 4/50 (8%) |
|ADJUSTED (b) | 17.9% 54.4% | 15.0% 60.7% |
|TERMINAL (d) | 5/28 (18%) 4/11 (36%) | 4/32 (13%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 700 (T) 409 | 688 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** | P=0.008 ** |
|INCIDENTAL TUMOR | P=0.010 ** | P=0.291 |
|LOGISTIC REGRESSION | P=0.008 ** | P=0.216 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.113 | P=0.487N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% | 6.3% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/11 (0%) | 2/32 (6%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 700 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.878N |
|INCIDENTAL TUMOR | (e) (e) | P=0.878N |
|LOGISTIC REGRESSION | (e) (e) | P=0.878N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.242N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/44 (0%) | 11/49 (22%) 1/45 (2%) |
|ADJUSTED (b) | 0.0% 0.0% | 32.9% 7.1% |
|TERMINAL (d) | 0/28 (0%) 0/10 (0%) | 10/32 (31%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 657 653 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.707N |
|INCIDENTAL TUMOR | (e) (e) | P=0.398N |
|LOGISTIC REGRESSION | (e) (e) | P=0.250N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.003N** |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 0/49 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 0.0% 7.2% |
|TERMINAL (d) | 0/28 (0%) 0/11 (0%) | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | --- 594 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.146 |
|INCIDENTAL TUMOR | (e) (e) | P=0.848 |
|LOGISTIC REGRESSION | (e) (e) | P=0.254 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.253 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/48 (2%) | 0/48 (0%) 2/48 (4%) |
|ADJUSTED (b) | 0.0% 9.1% | 0.0% 19.8% |
|TERMINAL (d) | 0/27 (0%) 1/11 (9%) | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 700 (T) | --- 618 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.321 | P=0.051 |
|INCIDENTAL TUMOR | P=0.321 | P=0.492 |
|LOGISTIC REGRESSION | P=0.321 | P=0.204 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.495 | P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 1/49 (2%) 43/50 (86%) |
|ADJUSTED (b) | | 2.2% 100.0% |
|TERMINAL (d) | | 0/32 (0%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | | 500 469 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** |
|INCIDENTAL TUMOR | | P<0.001 ** |
|LOGISTIC REGRESSION | | P<0.001 ** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 2/49 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 5.4% 5.9% |
|TERMINAL (d) | | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | | 668 645 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.536 |
|INCIDENTAL TUMOR | | P=0.389N |
|LOGISTIC REGRESSION | | P=0.667N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.492N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 2/49 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 5.4% 5.9% |
|TERMINAL (d) | | 0/32 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | | 668 645 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.536 |
|INCIDENTAL TUMOR | | P=0.389N |
|LOGISTIC REGRESSION | | P=0.667N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.492N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) | 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.2% | 3.1% 0.0% |
|TERMINAL (d) | 0/28 (0%) 1/11 (9%) | 1/32 (3%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 610 | 700 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076 | P=0.970N |
|INCIDENTAL TUMOR | P=0.130 | P=0.970N |
|LOGISTIC REGRESSION | P=0.108 | P=0.970N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | P=0.495N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) | 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.2% | 3.1% 0.0% |
|TERMINAL (d) | 0/28 (0%) 1/11 (9%) | 1/32 (3%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 610 | 700 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076 | P=0.970N |
|INCIDENTAL TUMOR | P=0.130 | P=0.970N |
|LOGISTIC REGRESSION | P=0.108 | P=0.970N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | P=0.495N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 4/49 (8%) 10/50 (20%) |
|ADJUSTED (b) | 2.7% 14.4% | 10.7% 65.8% |
|TERMINAL (d) | 0/28 (0%) 1/11 (9%) | 1/32 (3%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 578 587 | 663 486 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.358 | P=0.344 |
|LOGISTIC REGRESSION | P=0.362 | P=0.086 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.080 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 4/49 (8%) 10/50 (20%) |
|ADJUSTED (b) | 2.7% 14.4% | 10.7% 65.8% |
|TERMINAL (d) | 0/28 (0%) 1/11 (9%) | 1/32 (3%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 578 587 | 663 486 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.358 | P=0.344 |
|LOGISTIC REGRESSION | P=0.362 | P=0.086 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.080 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 11/50 (22%) | 15/49 (31%) 9/50 (18%) |
|ADJUSTED (b) | 39.1% 59.4% | 42.3% 48.4% |
|TERMINAL (d) | 10/28 (36%) 5/11 (45%) | 12/32 (38%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 409 409 | 657 590 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.035 * | P=0.002 ** |
|INCIDENTAL TUMOR | P=0.152 | P=0.624N |
|LOGISTIC REGRESSION | P=0.161 | P=0.620 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.109N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 13/50 (26%) | 18/49 (37%) 47/50 (94%) |
|ADJUSTED (b) | 43.3% 67.3% | 42.1% 100.0% |
|TERMINAL (d) | 8/28 (29%) 6/11 (55%) | 8/32 (25%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 409 357 | 132 469 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.109 | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.578 | P<0.001 ** |
|LOGISTIC REGRESSION | P=0.583N | P<0.001 ** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.257N | P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 100 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 20/50 (40%) | 28/49 (57%) 47/50 (94%) |
|ADJUSTED (b) | 67.8% 84.5% | 63.3% 100.0% |
|TERMINAL (d) | 16/28 (57%) 8/11 (73%) | 16/32 (50%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 409 357 | 132 469 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042 * | P<0.001 ** |
|INCIDENTAL TUMOR | P=0.519 | P=0.016 * |
|LOGISTIC REGRESSION | P=0.574 | P<0.001 ** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.115N | P<0.001 ** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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