TR 346 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05078 ETHYL CHLORIDE TIME: 14:19:25
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 06224
CONT: N01ES38061 CAS: 75-00-3
PATHOLOGIST: R. BUSCH
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05078 ETHYL CHLORIDE TIME: 14:19:25
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 06224
CONT: N01ES38061 CAS: 75-00-3
PATHOLOGIST: R. BUSCH
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 700 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 17 409 409 413 479 486 516 524 526 526 |
| 560 560 570 578 587 610 629 646 654 658 |
| 668 682 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 226 257 261 269 278 294 308 329 330 357 |
| 358 360 360 360 363 363 398 409 409 409 |
| 434 448 465 486 502 507 519 524 526 526 |
| 526 559 577 587 596 610 638 671 673 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 700 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 700 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 98.0 98.0 92.0 90.0 80.0 70.0 60.0 56.0 |
| | |
| | |
|15000 PPM | 100.0 100.0 92.0 68.0 60.0 54.0 38.0 30.0 26.0 22.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 22.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 532.1 437.7 |
|NATURAL DEATHS (C) | (30.3) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.1 495.4 |
|(STANDARD ERROR) | (17.7) (21.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 700 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 3 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 132 166 500 587 597 651 658 663 665 668 |
| 671 682 688 692 696 |
| CENSORED DEATHS |
| 52 329 657 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 48 CENSORED DEATHS 0 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 325 469 486 510 533 535 551 552 559 570 |
| 574 574 574 581 582 583 590 594 596 608 |
| 610 611 616 618 622 626 626 629 633 636 |
| 642 643 644 645 651 652 653 654 654 656 |
| 661 667 668 668 669 685 689 689 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 700 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 700 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 95.9 95.9 95.9 95.9 95.9 93.8 89.7 81.2 68.4 |
| | |
| | |
|15000 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 88.0 62.0 18.0 4.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.4% 4.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 581.1 605.5 |
|NATURAL DEATHS (C) | (47.2) ( 9.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 643.1 609.3 |
|(STANDARD ERROR) | (21.0) ( 9.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYL CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15000 PPM = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
104 +
|
| 1 1 2
| 1 2 2 1
96 + 2 2
| 22
| 22 1 1
| 2 2 11
88 + 2 2 1 1
| 2 2 11
| 2 2 11
| 2 2
80 + 22 1 1
|
P | 1 1
E | 1 1
R 72 + 11
C | 1 1
E | 2 2 1 1
N | 2 2 1 1
T 64 + 11
|
S | 2 2 1 1
U | 2 2 1 1
R 56 + 2 2 1 1
V | 2 2
I | 2 2
V | 2 2
A 48 + 2 2
L |
| 22
|
40 +
| 2 2
| 2 2
| 22
32 + 2 2
| 2 2
| 2 2
| 2 2
24 + 22
| 2 2
|
|
16 +
---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
0 10 20 30 40 50 60 70 80 90 100
WEEK
NOTE: 1 obs hidden.
ETHYL CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15000 PPM = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 1 2 2
| 1 2 2 1 2 1
| 2 2 1 1
90 + 1 1
| 2 2 11
| 22 11
| 2 2
80 + 11
| 1 1
| 2 2 11
| 22
P 70 + 11
E | 22 1
R | 22
C | 22
E 60 + 2 2
N |
T | 22
|
S 50 + 22
U |
R | 22
V |
I 40 + 22
V |
A | 2 2
L |
30 + 22
|
|
|
20 + 22
| 22
|
|
10 + 2 2
| 22
| 22
|
0 +
|
---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
0 10 20 30 40 50 60 70 80 90 100
WEEK
NOTE: 3 obs hidden.
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