TR 346 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) ETHYL CHLORIDE NTP Experiment-Test: 05078-01 Report: PEIRPT03 Study Type: CHRONIC Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 Facility: Battelle Northwest Chemical CAS #: 75-00-3 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 Early Deaths Moribund Sacrifice 19 24 Natural Death 4 Survivors Terminal Sacrifice 31 22 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (50) (49) Anus, Parasite Metazoan 1 (2%) Intestine Large, Cecum (50) (48) Parasite Metazoan 7 (14%) 6 (13%) Intestine Large, Colon (50) (49) Parasite Metazoan 4 (8%) 7 (14%) Intestine Large, Rectum (48) (44) Parasite Metazoan 6 (13%) 3 (7%) Liver (50) (50) Angiectasis 1 (2%) 1 (2%) Basophilic Focus 29 (58%) 22 (44%) Congestion 1 (2%) Degeneration 2 (4%) 2 (4%) Degeneration, Fatty 10 (20%) 6 (12%) Hematopoietic Cell Proliferation 3 (6%) 5 (10%) Hepatodiaphragmatic Nodule 3 (6%) Inflammation, Focal, Granulomatous 19 (38%) 21 (42%) Leukocytosis 3 (6%) 1 (2%) Necrosis 2 (4%) 8 (16%) Pigmentation 1 (2%) Thrombosis 2 (4%) Bile Duct, Hyperplasia 7 (14%) 12 (24%) Hepatocyte, Hyperplasia 2 (4%) Mesentery (1) (2) Fat, Inflammation, Chronic 1 (100%) 1 (50%) Pancreas (49) (50) Atrophy 15 (31%) 9 (18%) Cytomegaly 1 (2%) 2 (4%) Hyperplasia 1 (2%) Inflammation 1 (2%) Artery, Mineralization 1 (2%) Pharynx (2) Palate, Inflammation, Chronic 1 (50%) Salivary Glands (48) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Chronic 1 (2%) Inflammation, Chronic, Suppurative 1 (2%) Duct, Hyperplasia 4 (8%) 6 (12%) Stomach, Forestomach (46) (50) Inflammation, Chronic 2 (4%) Inflammation, Suppurative 1 (2%) Ulcer 1 (2%) 1 (2%) Epithelium, Hyperplasia 6 (13%) 1 (2%) Stomach, Glandular (50) (49) Mineralization 1 (2%) Ulcer 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Inflammation 1 (100%) Heart (50) (50) Inflammation, Chronic 42 (84%) 41 (82%) Artery, Mineralization 1 (2%) Atrium, Thrombosis 2 (4%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (50) Degeneration 1 (2%) Degeneration, Fatty 13 (26%) 18 (36%) Focal Cellular Change 1 (2%) Hematopoietic Cell Proliferation 5 (10%) 6 (12%) Hemorrhage 1 (2%) Hyperplasia 6 (12%) 9 (18%) Hypertrophy 1 (2%) 1 (2%) Necrosis 1 (2%) Adrenal Gland, Medulla (35) (40) Hyperplasia 4 (11%) 3 (8%) Necrosis 1 (3%) Islets, Pancreatic (49) (50) Hyperplasia 1 (2%) Parathyroid Gland (34) (31) Hyperplasia 1 (3%) Pituitary Gland (49) (50) Pars Distalis, Cyst 3 (6%) 4 (8%) Pars Distalis, Hemorrhage 1 (2%) Pars Distalis, Hyperplasia 10 (20%) 11 (22%) Pars Distalis, Infiltration Cellular, Mixed Cell 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Metaplasia, Osseous 1 (2%) Pars Distalis, Pigmentation, Hemosiderin 1 (2%) 2 (4%) Thyroid Gland (49) (48) Mineralization 1 (2%) C-Cell, Hyperplasia 33 (67%) 31 (65%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (46) (43) Cyst 2 (4%) Hyperplasia 1 (2%) 1 (2%) Inflammation, Suppurative 4 (9%) 3 (7%) Duct, Hyperplasia 1 (2%) 1 (2%) Ovary (49) (50) Atrophy 1 (2%) 4 (8%) Cyst 2 (4%) 5 (10%) Interstitium, Hyperplasia 2 (4%) 1 (2%) Uterus (49) (50) Hemorrhage 1 (2%) Inflammation, Suppurative 1 (2%) Endometrium, Hyperplasia 1 (2%) 1 (2%) Endometrium, Hyperplasia, Cystic 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) Infiltration Cellular, Histiocyte 1 (2%) Myelofibrosis 2 (4%) Lymph Node (48) (49) Mesenteric, Angiectasis 1 (2%) Mesenteric, Inflammation, Granulomatous 1 (2%) Renal, Inflammation, Granulomatous 1 (2%) Lymph Node, Bronchial (47) (47) Congestion 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) Inflammation, Granulomatous 1 (2%) Lymph Node, Mandibular (39) (43) Angiectasis 1 (3%) Depletion Cellular 1 (2%) Hyperplasia 9 (23%) 8 (19%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (50) (50) Fibrosis 1 (2%) Hematocyst 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 7 (14%) Inflammation, Focal, Granulomatous 1 (2%) 2 (4%) Pigmentation, Hemosiderin 2 (4%) Thymus (38) (39) Epithelial Cell, Hyperplasia 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (48) (50) Hyperplasia 45 (94%) 47 (94%) Skin (47) (49) Acanthosis 2 (4%) 2 (4%) Inflammation 1 (2%) Inflammation, Suppurative 3 (6%) Subcutaneous Tissue, Inflammation, Chronic 1 (2%) Subcutaneous Tissue, Inflammation, Granulomatous 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) Fibrous Osteodystrophy 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) Gliosis 1 (2%) Hemorrhage, Focal 2 (4%) 2 (4%) Inflammation 1 (2%) Necrosis, Focal 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) Inflammation, Suppurative 10 (20%) 7 (14%) Metaplasia, Squamous 1 (2%) Epithelium, Hyperplasia 2 (4%) Submucosa, Inflammation 1 (2%) 1 (2%) Lung (50) (50) Congestion 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Edema 1 (2%) 2 (4%) Foreign Body 1 (2%) Hemorrhage 4 (8%) Infiltration Cellular, Histiocyte 8 (16%) 13 (26%) Inflammation, Chronic, Diffuse 1 (2%) 1 (2%) Inflammation, Chronic, Focal 4 (8%) 4 (8%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 4 (8%) 8 (16%) Bronchiole, Epithelium, Hyperplasia 1 (2%) Mediastinum, Infiltration Cellular, Mononuclear Cell 1 (2%) Perivascular, Infiltration Cellular, Mononuclear Cell 21 (42%) 19 (38%) Nose (50) (50) Inflammation, Suppurative 6 (12%) 6 (12%) Thrombosis 2 (4%) 5 (10%) Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 10 (20%) Respiratory Epithelium, Hyperplasia 4 (8%) 10 (20%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%) Submucosa, Inflammation 25 (50%) 34 (68%) Vomeronasal Organ, Inflammation, Suppurative 1 (2%) 1 (2%) Trachea (50) (49) Inflammation, Suppurative 2 (4%) 1 (2%) Epithelium, Hyperplasia 1 (2%) Submucosa, Inflammation 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (5) Cataract 1 (33%) 2 (40%) Hemorrhage 1 (20%) Inflammation, Chronic 1 (20%) Synechia 1 (33%) 1 (20%) Bilateral, Cataract 1 (33%) 1 (20%) Retina, Atrophy 1 (33%) 2 (40%) Harderian Gland (1) Inflammation, Suppurative 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Hydronephrosis 1 (2%) Inflammation, Suppurative 2 (4%) Mineralization 1 (2%) Nephropathy 47 (94%) 42 (84%) Renal Tubule, Hyperplasia, Focal 1 (2%) 2 (4%) Urinary Bladder (49) (49) Hemorrhage 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 Early Deaths Moribund Sacrifice 28 33 Natural Death 6 9 Survivors Terminal Sacrifice 16 8 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (49) (45) Parasite Metazoan 8 (16%) 4 (9%) Intestine Large, Colon (50) (45) Parasite Metazoan 5 (10%) 5 (11%) Intestine Large, Rectum (47) (43) Parasite Metazoan 4 (9%) 5 (12%) Serosa, Inflammation, Chronic 1 (2%) 1 (2%) Serosa, Thrombosis 1 (2%) Liver (50) (50) Angiectasis 1 (2%) Basophilic Focus 18 (36%) 7 (14%) Clear Cell Focus 3 (6%) 2 (4%) Congestion 2 (4%) Degeneration 2 (4%) 2 (4%) Degeneration, Cystic 3 (6%) 9 (18%) Degeneration, Fatty 9 (18%) 5 (10%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 3 (6%) Hemorrhage 1 (2%) Hepatodiaphragmatic Nodule 2 (4%) 2 (4%) Inflammation, Focal, Granulomatous 6 (12%) 5 (10%) Necrosis 7 (14%) 4 (8%) Pigmentation 1 (2%) Bile Duct, Hyperplasia 44 (88%) 34 (68%) Hepatocyte, Hyperplasia 3 (6%) 8 (16%) Pancreas (50) (49) Atrophy 24 (48%) 17 (35%) Cytomegaly 2 (4%) 1 (2%) Inflammation 1 (2%) Pigmentation, Hemosiderin 1 (2%) 1 (2%) Artery, Intima, Hyperplasia 1 (2%) Perivascular, Inflammation 3 (6%) Pharynx (2) (1) Inflammation, Suppurative 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Palate, Inflammation, Chronic 2 (100%) Salivary Glands (50) (50) Duct, Hyperplasia 10 (20%) 15 (30%) Duct, Inflammation, Suppurative 2 (4%) 1 (2%) Stomach, Forestomach (48) (49) Hyperkeratosis 1 (2%) Inflammation, Chronic 2 (4%) Inflammation, Suppurative 3 (6%) 1 (2%) Ulcer 4 (8%) 1 (2%) Epithelium, Hyperplasia 2 (4%) 2 (4%) Serosa, Inflammation, Chronic 1 (2%) Stomach, Glandular (50) (50) Erosion 3 (6%) Hyperplasia, Lymphoid 1 (2%) Mineralization 2 (4%) Epithelium, Hyperplasia 1 (2%) Serosa, Inflammation, Chronic 1 (2%) Tooth (3) Gingiva, Hyperplasia, Pseudoepitheliomatous 1 (33%) Peridontal Tissue, Inflammation, Chronic, Suppurative 2 (67%) Pulp, Inflammation, Suppurative 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) Inflammation, Chronic 43 (86%) 46 (92%) Artery, Mineralization 1 (2%) Atrium, Thrombosis 2 (4%) 2 (4%) Perivascular, Inflammation 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (50) Degeneration, Fatty 23 (46%) 26 (52%) Hematopoietic Cell Proliferation 2 (4%) 2 (4%) Hyperplasia 13 (26%) 6 (12%) Hypertrophy 2 (4%) Adrenal Gland, Medulla (36) (48) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 11 (31%) 16 (33%) Islets, Pancreatic (48) (48) Hyperplasia 3 (6%) 4 (8%) Parathyroid Gland (31) (41) Hyperplasia 3 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pituitary Gland (49) (50) Pars Distalis, Cyst 1 (2%) 2 (4%) Pars Distalis, Hemorrhage 1 (2%) 1 (2%) Pars Distalis, Hyperplasia 10 (20%) 10 (20%) Pars Distalis, Inflammation, Suppurative 1 (2%) Pars Distalis, Necrosis 1 (2%) Pars Distalis, Pigmentation, Hemosiderin 1 (2%) Thyroid Gland (49) (47) C-Cell, Hyperplasia 19 (39%) 23 (49%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) (4) Inflammation, Chronic 1 (100%) 1 (25%) Necrosis 1 (100%) 1 (25%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (37) (42) Granuloma Sperm 1 (2%) Inflammation, Chronic 1 (3%) Mineralization 1 (3%) Vacuolization Cytoplasmic 14 (38%) 15 (36%) Penis (1) Inflammation, Suppurative 1 (100%) Preputial Gland (47) (45) Cyst 1 (2%) 1 (2%) Inflammation, Suppurative 10 (21%) 3 (7%) Duct, Hyperplasia 1 (2%) Prostate (50) (48) Hyperplasia 4 (8%) 11 (23%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 16 (32%) 13 (27%) Seminal Vesicle (7) (6) Inflammation, Suppurative 7 (100%) 5 (83%) Testes (50) (50) Atrophy 27 (54%) 29 (58%) Interstitial Cell, Hyperplasia 12 (24%) 15 (30%) Perivascular, Inflammation 3 (6%) 8 (16%) Tunic, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) Hyperplasia 1 (2%) Myelofibrosis 1 (2%) 1 (2%) Lymph Node (49) (50) Mesenteric, Hematopoietic Cell Proliferation 1 (2%) Mesenteric, Inflammation, Granulomatous 1 (2%) Pancreatic, Hyperplasia 1 (2%) Renal, Hematopoietic Cell Proliferation 1 (2%) Lymph Node, Bronchial (42) (48) Hyperplasia 2 (5%) 2 (4%) Pigmentation, Hemosiderin 1 (2%) Lymph Node, Mandibular (45) (38) Angiectasis 1 (2%) 2 (5%) Hyperplasia 19 (42%) 11 (29%) Spleen (50) (50) Fibrosis 3 (6%) 9 (18%) Hematocyst 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 2 (4%) Thymus (39) (41) Epithelial Cell, Hyperplasia 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (13) (14) Galactocele 3 (21%) Hyperplasia 8 (62%) 10 (71%) Skin (49) (46) Acanthosis 1 (2%) Ectopic Tissue 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) Pigmentation, Hemosiderin 1 (2%) Prepuce, Abscess 1 (2%) Prepuce, Epithelium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (49) Fibrous Osteodystrophy 4 (8%) Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) Hemorrhage, Focal 3 (6%) 3 (6%) Hydrocephalus 1 (2%) Necrosis, Focal 2 (4%) Meninges, Hemorrhage 1 (2%) Meninges, Inflammation, Suppurative 1 (2%) Meninges, Pigmentation, Hemosiderin 1 (2%) Spinal Cord (1) Degeneration 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (44) Inflammation, Suppurative 14 (29%) 21 (48%) Metaplasia, Squamous 1 (2%) Lung (50) (50) Congestion 1 (2%) 5 (10%) Edema 1 (2%) 2 (4%) Erythrophagocytosis 1 (2%) Hemorrhage 4 (8%) 3 (6%) Infiltration Cellular, Histiocyte 5 (10%) 13 (26%) Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%) Inflammation, Chronic, Focal 4 (8%) 2 (4%) Metaplasia, Osseous 1 (2%) 2 (4%) Alveolar Epithelium, Hyperplasia 6 (12%) 7 (14%) Artery, Mediastinum, Mineralization 1 (2%) Bronchiole, Inflammation, Suppurative 1 (2%) Perivascular, Infiltration Cellular, Mononuclear Cell 9 (18%) 14 (28%) Nose (50) (49) Edema 1 (2%) Inflammation, Suppurative 12 (24%) 13 (27%) Thrombosis 8 (16%) 7 (14%) Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 8 (16%) Respiratory Epithelium, Hyperplasia 9 (18%) 14 (29%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) Submucosa, Inflammation 22 (44%) 23 (47%) Vomeronasal Organ, Inflammation, Suppurative 2 (4%) 1 (2%) Trachea (50) (49) Inflammation, Suppurative 2 (4%) 7 (14%) Epithelium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (7) Cataract 1 (14%) Degeneration 1 (100%) 1 (14%) Inflammation, Chronic 1 (14%) Synechia 4 (57%) Bilateral, Cataract 3 (43%) Retina, Atrophy 3 (43%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Fatty Change 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 3 (6%) Hydronephrosis 1 (2%) Inflammation, Suppurative 4 (8%) 3 (6%) Nephropathy 49 (98%) 49 (98%) Pelvis, Inflammation, Suppurative 2 (4%) Pelvis, Necrosis 1 (2%) Pelvis, Epithelium, Hyperplasia 1 (2%) 3 (6%) Urethra (1) Inflammation, Suppurative 1 (100%) Epithelium, Hyperplasia 1 (100%) Urinary Bladder (50) (49) Hemorrhage 1 (2%) Inflammation 1 (2%) Inflammation, Suppurative 2 (4%) 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 84392-84392/84392 --multipart-boundary--