TR 346 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ETHYL CHLORIDE
NTP Experiment-Test: 05078-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 19 24
Natural Death 4
Survivors
Terminal Sacrifice 31 22
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49)
Anus, Parasite Metazoan 1 (2%)
Intestine Large, Cecum (50) (48)
Parasite Metazoan 7 (14%) 6 (13%)
Intestine Large, Colon (50) (49)
Parasite Metazoan 4 (8%) 7 (14%)
Intestine Large, Rectum (48) (44)
Parasite Metazoan 6 (13%) 3 (7%)
Liver (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 29 (58%) 22 (44%)
Congestion 1 (2%)
Degeneration 2 (4%) 2 (4%)
Degeneration, Fatty 10 (20%) 6 (12%)
Hematopoietic Cell Proliferation 3 (6%) 5 (10%)
Hepatodiaphragmatic Nodule 3 (6%)
Inflammation, Focal, Granulomatous 19 (38%) 21 (42%)
Leukocytosis 3 (6%) 1 (2%)
Necrosis 2 (4%) 8 (16%)
Pigmentation 1 (2%)
Thrombosis 2 (4%)
Bile Duct, Hyperplasia 7 (14%) 12 (24%)
Hepatocyte, Hyperplasia 2 (4%)
Mesentery (1) (2)
Fat, Inflammation, Chronic 1 (100%) 1 (50%)
Pancreas (49) (50)
Atrophy 15 (31%) 9 (18%)
Cytomegaly 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Artery, Mineralization 1 (2%)
Pharynx (2)
Palate, Inflammation, Chronic 1 (50%)
Salivary Glands (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Suppurative 1 (2%)
Duct, Hyperplasia 4 (8%) 6 (12%)
Stomach, Forestomach (46) (50)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 6 (13%) 1 (2%)
Stomach, Glandular (50) (49)
Mineralization 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation 1 (100%)
Heart (50) (50)
Inflammation, Chronic 42 (84%) 41 (82%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Degeneration 1 (2%)
Degeneration, Fatty 13 (26%) 18 (36%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 6 (12%)
Hemorrhage 1 (2%)
Hyperplasia 6 (12%) 9 (18%)
Hypertrophy 1 (2%) 1 (2%)
Necrosis 1 (2%)
Adrenal Gland, Medulla (35) (40)
Hyperplasia 4 (11%) 3 (8%)
Necrosis 1 (3%)
Islets, Pancreatic (49) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (34) (31)
Hyperplasia 1 (3%)
Pituitary Gland (49) (50)
Pars Distalis, Cyst 3 (6%) 4 (8%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 10 (20%) 11 (22%)
Pars Distalis, Infiltration Cellular, Mixed
Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Metaplasia, Osseous 1 (2%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Thyroid Gland (49) (48)
Mineralization 1 (2%)
C-Cell, Hyperplasia 33 (67%) 31 (65%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (43)
Cyst 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Suppurative 4 (9%) 3 (7%)
Duct, Hyperplasia 1 (2%) 1 (2%)
Ovary (49) (50)
Atrophy 1 (2%) 4 (8%)
Cyst 2 (4%) 5 (10%)
Interstitium, Hyperplasia 2 (4%) 1 (2%)
Uterus (49) (50)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Infiltration Cellular, Histiocyte 1 (2%)
Myelofibrosis 2 (4%)
Lymph Node (48) (49)
Mesenteric, Angiectasis 1 (2%)
Mesenteric, Inflammation, Granulomatous 1 (2%)
Renal, Inflammation, Granulomatous 1 (2%)
Lymph Node, Bronchial (47) (47)
Congestion 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mandibular (39) (43)
Angiectasis 1 (3%)
Depletion Cellular 1 (2%)
Hyperplasia 9 (23%) 8 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (50)
Fibrosis 1 (2%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 7 (14%)
Inflammation, Focal, Granulomatous 1 (2%) 2 (4%)
Pigmentation, Hemosiderin 2 (4%)
Thymus (38) (39)
Epithelial Cell, Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50)
Hyperplasia 45 (94%) 47 (94%)
Skin (47) (49)
Acanthosis 2 (4%) 2 (4%)
Inflammation 1 (2%)
Inflammation, Suppurative 3 (6%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Gliosis 1 (2%)
Hemorrhage, Focal 2 (4%) 2 (4%)
Inflammation 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49)
Inflammation, Suppurative 10 (20%) 7 (14%)
Metaplasia, Squamous 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Submucosa, Inflammation 1 (2%) 1 (2%)
Lung (50) (50)
Congestion 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Edema 1 (2%) 2 (4%)
Foreign Body 1 (2%)
Hemorrhage 4 (8%)
Infiltration Cellular, Histiocyte 8 (16%) 13 (26%)
Inflammation, Chronic, Diffuse 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 4 (8%) 4 (8%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 8 (16%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Mediastinum, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 21 (42%) 19 (38%)
Nose (50) (50)
Inflammation, Suppurative 6 (12%) 6 (12%)
Thrombosis 2 (4%) 5 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 10 (20%)
Respiratory Epithelium, Hyperplasia 4 (8%) 10 (20%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%)
Submucosa, Inflammation 25 (50%) 34 (68%)
Vomeronasal Organ, Inflammation, Suppurative 1 (2%) 1 (2%)
Trachea (50) (49)
Inflammation, Suppurative 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Submucosa, Inflammation 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (5)
Cataract 1 (33%) 2 (40%)
Hemorrhage 1 (20%)
Inflammation, Chronic 1 (20%)
Synechia 1 (33%) 1 (20%)
Bilateral, Cataract 1 (33%) 1 (20%)
Retina, Atrophy 1 (33%) 2 (40%)
Harderian Gland (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Hydronephrosis 1 (2%)
Inflammation, Suppurative 2 (4%)
Mineralization 1 (2%)
Nephropathy 47 (94%) 42 (84%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 2 (4%)
Urinary Bladder (49) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 28 33
Natural Death 6 9
Survivors
Terminal Sacrifice 16 8
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (45)
Parasite Metazoan 8 (16%) 4 (9%)
Intestine Large, Colon (50) (45)
Parasite Metazoan 5 (10%) 5 (11%)
Intestine Large, Rectum (47) (43)
Parasite Metazoan 4 (9%) 5 (12%)
Serosa, Inflammation, Chronic 1 (2%) 1 (2%)
Serosa, Thrombosis 1 (2%)
Liver (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 18 (36%) 7 (14%)
Clear Cell Focus 3 (6%) 2 (4%)
Congestion 2 (4%)
Degeneration 2 (4%) 2 (4%)
Degeneration, Cystic 3 (6%) 9 (18%)
Degeneration, Fatty 9 (18%) 5 (10%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 2 (4%)
Inflammation, Focal, Granulomatous 6 (12%) 5 (10%)
Necrosis 7 (14%) 4 (8%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 44 (88%) 34 (68%)
Hepatocyte, Hyperplasia 3 (6%) 8 (16%)
Pancreas (50) (49)
Atrophy 24 (48%) 17 (35%)
Cytomegaly 2 (4%) 1 (2%)
Inflammation 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Artery, Intima, Hyperplasia 1 (2%)
Perivascular, Inflammation 3 (6%)
Pharynx (2) (1)
Inflammation, Suppurative 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Palate, Inflammation, Chronic 2 (100%)
Salivary Glands (50) (50)
Duct, Hyperplasia 10 (20%) 15 (30%)
Duct, Inflammation, Suppurative 2 (4%) 1 (2%)
Stomach, Forestomach (48) (49)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 3 (6%) 1 (2%)
Ulcer 4 (8%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 2 (4%)
Serosa, Inflammation, Chronic 1 (2%)
Stomach, Glandular (50) (50)
Erosion 3 (6%)
Hyperplasia, Lymphoid 1 (2%)
Mineralization 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Tooth (3)
Gingiva, Hyperplasia, Pseudoepitheliomatous 1 (33%)
Peridontal Tissue, Inflammation, Chronic,
Suppurative 2 (67%)
Pulp, Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Inflammation, Chronic 43 (86%) 46 (92%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 2 (4%) 2 (4%)
Perivascular, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Degeneration, Fatty 23 (46%) 26 (52%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Hyperplasia 13 (26%) 6 (12%)
Hypertrophy 2 (4%)
Adrenal Gland, Medulla (36) (48)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 11 (31%) 16 (33%)
Islets, Pancreatic (48) (48)
Hyperplasia 3 (6%) 4 (8%)
Parathyroid Gland (31) (41)
Hyperplasia 3 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (49) (50)
Pars Distalis, Cyst 1 (2%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 10 (20%) 10 (20%)
Pars Distalis, Inflammation, Suppurative 1 (2%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%)
Thyroid Gland (49) (47)
C-Cell, Hyperplasia 19 (39%) 23 (49%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (4)
Inflammation, Chronic 1 (100%) 1 (25%)
Necrosis 1 (100%) 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (37) (42)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (3%)
Mineralization 1 (3%)
Vacuolization Cytoplasmic 14 (38%) 15 (36%)
Penis (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (47) (45)
Cyst 1 (2%) 1 (2%)
Inflammation, Suppurative 10 (21%) 3 (7%)
Duct, Hyperplasia 1 (2%)
Prostate (50) (48)
Hyperplasia 4 (8%) 11 (23%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 16 (32%) 13 (27%)
Seminal Vesicle (7) (6)
Inflammation, Suppurative 7 (100%) 5 (83%)
Testes (50) (50)
Atrophy 27 (54%) 29 (58%)
Interstitial Cell, Hyperplasia 12 (24%) 15 (30%)
Perivascular, Inflammation 3 (6%) 8 (16%)
Tunic, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48)
Hyperplasia 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (49) (50)
Mesenteric, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Inflammation, Granulomatous 1 (2%)
Pancreatic, Hyperplasia 1 (2%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Lymph Node, Bronchial (42) (48)
Hyperplasia 2 (5%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (45) (38)
Angiectasis 1 (2%) 2 (5%)
Hyperplasia 19 (42%) 11 (29%)
Spleen (50) (50)
Fibrosis 3 (6%) 9 (18%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Thymus (39) (41)
Epithelial Cell, Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (14)
Galactocele 3 (21%)
Hyperplasia 8 (62%) 10 (71%)
Skin (49) (46)
Acanthosis 1 (2%)
Ectopic Tissue 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Prepuce, Abscess 1 (2%)
Prepuce, Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49)
Fibrous Osteodystrophy 4 (8%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Hemorrhage, Focal 3 (6%) 3 (6%)
Hydrocephalus 1 (2%)
Necrosis, Focal 2 (4%)
Meninges, Hemorrhage 1 (2%)
Meninges, Inflammation, Suppurative 1 (2%)
Meninges, Pigmentation, Hemosiderin 1 (2%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (44)
Inflammation, Suppurative 14 (29%) 21 (48%)
Metaplasia, Squamous 1 (2%)
Lung (50) (50)
Congestion 1 (2%) 5 (10%)
Edema 1 (2%) 2 (4%)
Erythrophagocytosis 1 (2%)
Hemorrhage 4 (8%) 3 (6%)
Infiltration Cellular, Histiocyte 5 (10%) 13 (26%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 4 (8%) 2 (4%)
Metaplasia, Osseous 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 6 (12%) 7 (14%)
Artery, Mediastinum, Mineralization 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 9 (18%) 14 (28%)
Nose (50) (49)
Edema 1 (2%)
Inflammation, Suppurative 12 (24%) 13 (27%)
Thrombosis 8 (16%) 7 (14%)
Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 8 (16%)
Respiratory Epithelium, Hyperplasia 9 (18%) 14 (29%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Submucosa, Inflammation 22 (44%) 23 (47%)
Vomeronasal Organ, Inflammation, Suppurative 2 (4%) 1 (2%)
Trachea (50) (49)
Inflammation, Suppurative 2 (4%) 7 (14%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (7)
Cataract 1 (14%)
Degeneration 1 (100%) 1 (14%)
Inflammation, Chronic 1 (14%)
Synechia 4 (57%)
Bilateral, Cataract 3 (43%)
Retina, Atrophy 3 (43%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Fatty Change 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Hydronephrosis 1 (2%)
Inflammation, Suppurative 4 (8%) 3 (6%)
Nephropathy 49 (98%) 49 (98%)
Pelvis, Inflammation, Suppurative 2 (4%)
Pelvis, Necrosis 1 (2%)
Pelvis, Epithelium, Hyperplasia 1 (2%) 3 (6%)
Urethra (1)
Inflammation, Suppurative 1 (100%)
Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (50) (49)
Hemorrhage 1 (2%)
Inflammation 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 84392-84392/84392
--multipart-boundary--