TR 346 Rat Pathology Tables
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 Facility: Battelle Northwest Chemical CAS #: 75-00-3 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2| | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + + + + + + + + + + + + M M + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + I + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | I + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Small, Ileum | + + M + + + + + + + + + + M + + + + + + + + + + +| Sarcoma, Metastatic, Tissue NOS | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X X X X| Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Tissue NOS | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + M + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X | Sarcoma, Metastatic, Bone | X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2| | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | M M + + + M + + + + + I + + + + M + + + M + + M M| Leukemia Mononuclear | X X | Pheochromocytoma Benign | | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | M M + + + + + + + I + M M + + + M + M + M + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X| Pars Distalis, Carcinoma | X X X | Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant Undifferentiated | | Cell Type | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + + + + + + + M + + + M + + + + M + +| Adenoma | X | Carcinoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Bone | X | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2| | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | Mediastinal, Leukemia Mononuclear | | Mesenteric, Leukemia Mononuclear | X | Mesenteric, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Leukemia Mononuclear | X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + M + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Bone | X | Mesenteric, Sarcoma, Metastatic, | | Tissue NOS | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + M + + M + + + + + + + + M I M +| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leukemia Mononuclear | X X X X X X X X X| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + M + + + + + M + M + + + + + M + + M + + M + + I| Leukemia Mononuclear | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + + + + + + M + + + +| Adenoma | | Fibroadenoma | X X X X X X| Fibroadenoma, Multiple | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + M M + + + + + + + + + M + + + + + + +| Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | Periosteum, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2| | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X X X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X| Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| | | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + + M +| 45 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Sarcoma, Metastatic, Tissue NOS | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 19 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 | Leukemia Mononuclear | X X X X | 6 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Tissue NOS | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + M + + + + + + M + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + M + +| 46 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Lymphoma Malignant | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| | | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Leukemia Mononuclear | X X | 6 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + M + M + + + + + + I + + + M + + + I + + M I| 35 | Leukemia Mononuclear | X X X X X | 7 | Pheochromocytoma Benign | X | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + M M M + + + + + + + + M + M +| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X X | 26 | Pars Distalis, Carcinoma | X X X | 6 | Pars Distalis, Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | C-Cell, Adenoma | X X X | 5 | C-Cell, Carcinoma | X | 3 | Follicular Cell, Adenoma | X | 1 | Follicular Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Adenoma | | 1 | Carcinoma | | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 6 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| | | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Mediastinal, Leukemia Mononuclear | X | 1 | Mesenteric, Leukemia Mononuclear | X | 2 | Mesenteric, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 | Leukemia Mononuclear | X X X X X X | 8 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Bone | | 1 | Mesenteric, Sarcoma, Metastatic, | | | Tissue NOS | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + + + + M M + + + + + + + + M M + + +| 39 | Leukemia Mononuclear | X X X | 5 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 19 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + M M + + + + + + M + + + + + + M + + + M| 38 | Leukemia Mononuclear | X X X | 5 | Lymphoma Malignant Undifferentiated | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| | | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X X | 2 | Fibroadenoma | X X X X X | 11 | Fibroadenoma, Multiple | | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | Periosteum, Leukemia Mononuclear | X X X | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | X X | 5 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X X X X X | 15 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + M + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| | | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 6 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 20 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3| | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + M A M + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + M + + + + + + + A A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | Leukemia Lymphocytic | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | | Schwannoma Malignant, Metastatic, | | Stomach | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Leukemia Mononuclear | X X X | Schwannoma Malignant, Metastatic, | | Stomach | | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Leukemia Lymphocytic | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3| | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Leukemia Lymphocytic | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | I M + + + + + + + + M + + + M + I M + M + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + M + M M M + + + + + + + M M M M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | Pars Distalis, Carcinoma | X X | Pars Distalis, Carcinoma, Metastatic,| | Zymbal's Gland | | Pars Distalis, Leukemia Mononuclear | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + A + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + I + + M M + + + + + M + + M + +| Adenoma | X X X| Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3| | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesenteric, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + M| Leukemia Lymphocytic | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | M M + + + + + + M + + M + + M + + M + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Adenoma | X | Fibroadenoma | X X X X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| Basal Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | Periosteum, Leukemia Mononuclear | X X X | __________________________________________________________________________| Skeletal Muscle | | Fibrous Histiocytoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X | Meninges, Carcinoma, Metastatic, | | Zymbal's Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3| | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Lymphocytic | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma, Metastatic, | | Skin | X | Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | Leukemia Mononuclear | X X X X X X X X X X| Sarcoma, Metastatic, Ear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| Leukemia Lymphocytic | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Sarcoma | | __________________________________________________________________________| Eye | + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Uncertain Primary Site | X | Leukemia Lymphocytic | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Lymphocytic | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| | DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| | | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + A + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + M + + M + + + + + + + + A + + + + + +| 43 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | X | 1 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X X X X X X X X| 25 | __________________________________________________________________________|____________| Mesentery | + + | 2 | Schwannoma Malignant, Metastatic, | | | Stomach | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Leukemia Mononuclear | X | 4 | Schwannoma Malignant, Metastatic, | | | Stomach | X | 1 | __________________________________________________________________________|____________| Pharynx | + | 2 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Malignant | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| | DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| | | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X X | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Leukemia Lymphocytic | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | X | 1 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + I + + + + + + M +| 40 | Leukemia Mononuclear | X X X | 6 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + + M M M + + + I M + M + + M M + + +| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| 30 | Pars Distalis, Carcinoma | X | 3 | Pars Distalis, Carcinoma, Metastatic,| | | Zymbal's Gland | X | 1 | Pars Distalis, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X | 2 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + M + + + + + + + + + + + + + + + +| 43 | Adenoma | X | 4 | Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| | DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| | | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Malignant | | 1 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Polyp Stromal | X X X | 7 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Mesenteric, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | I + + + + + + + + + + + + + + + + + + + M + + + +| 47 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | X | 1 | Leukemia Mononuclear | X X X X| 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + M M + + + + + + + + M + + + M| 43 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic | | 1 | Leukemia Mononuclear | X X X X X X X X| 23 | __________________________________________________________________________|____________| Thymus | + + + + + + M M M M + + + M + + + + + + + + + + +| 39 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Adenoma | | 1 | Fibroadenoma | X X X | 8 | Fibroadenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basal Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| | DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| | | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | X | 1 | Periosteum, Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Fibrous Histiocytoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X X | 3 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 2 | Leukemia Mononuclear | X X | 3 | Meninges, Carcinoma, Metastatic, | | | Zymbal's Gland | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Lymphocytic | X | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma, Metastatic, | | | Skin | | 1 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | X | 1 | Leukemia Mononuclear | X X X X X X| 16 | Sarcoma, Metastatic, Ear | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 2 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Eye | + + | 5 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| | DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| | | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | Adenoma | | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Uncertain Primary Site | | 1 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Lymphocytic | X | 1 | Leukemia Mononuclear | X X X X X X X X X| 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7| DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2| | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + M + + + + + M + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + M + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Mesentery | + | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + I + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Schwannoma NOS | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X| Lymphoma Malignant Histiocytic | X | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + M + + + M + + M + + M M M + + + + + + + M +| Leukemia Mononuclear | X X X X X X| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7| DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2| | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| Adenoma | X X X| __________________________________________________________________________| Parathyroid Gland | M M M M + + M M + + M M M M + + + + + + M + + + +| Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | Pars Distalis, Carcinoma | | Pars Distalis, Leukemia Mononuclear | X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Adenoma, Multiple | X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + M + M M + + M + + + + M + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + I + M + + + + + + + + + + +| Adenoma | | Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesenteric, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M M + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7| DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2| | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + I + M + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | __________________________________________________________________________| Thymus | M + + M + + + + + + + + M M + + + + + M + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + M M M + M M M + + M M M M M M M M M M M M +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + M + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | | Leukemia Mononuclear | X X | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + I + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| Mediastinum, Mesothelioma Benign | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | M + | __________________________________________________________________________| Eye | +| __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Lipoma, Moderate | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7| DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2| | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Urethra | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant, Metastatic, | | Testes | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| Lymphoma Malignant Histiocytic | X | Mesothelioma Benign | | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| | DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| | | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 31 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Pharynx | + + | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + +| 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 12 | Schwannoma NOS | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X X X | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| | DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| | | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Lymphoma Malignant Histiocytic | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + I + + + M I + + M + M + M M + + + + + + + + + +| 36 | Leukemia Mononuclear | X X | 8 | Pheochromocytoma Benign | X X X X | 7 | Bilateral, Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Adenoma | X X X | 6 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M + + M + + + M + + + + + M + + + M M + + +| 31 | Adenoma | X| 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 7 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 31 | Pars Distalis, Carcinoma | X | 1 | Pars Distalis, Leukemia Mononuclear | | 3 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X X X | 6 | C-Cell, Adenoma, Multiple | | 1 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + I + + M + + M + M M + + + + M + M + M + + + +| 37 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 | Adenoma | X | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + | 7 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X| 19 | Interstitial Cell, Adenoma | X X X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| | DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| | | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Mesenteric, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + M + + + + M + + M + M + + + + M + + + +| 42 | Leukemia Mononuclear | X X X X | 15 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + M| 45 | Leukemia Mononuclear | X X X X | 14 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 30 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Thymus | + + M + + + M + + + + + M + + M M + + + + + M + +| 39 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M M M M M M M M + M M M + + M M M M + + + +| 13 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Keratoacanthoma | X X X | 4 | Subcutaneous Tissue, Fibroma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granular Cell Tumor Malignant | X | 1 | Leukemia Mononuclear | | 2 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 24 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| | DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| | | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Mediastinum, Mesothelioma Benign | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 12 | Lipoma, Moderate | | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Urethra | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 33 | Lymphoma Malignant Histiocytic | | 1 | Mesothelioma Benign | X | 1 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7| DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0| | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M M + + + + + + + + + + + + + + M + M + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A| Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M A A + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + M + + + + + + + + + + + + + A A + M A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + A A + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| Mesothelioma Malignant, Metastatic, | | Testes | | Neoplastic Nodule, Multiple | | __________________________________________________________________________| Mesentery | | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X X| Pheochromocytoma Malignant | | Pheochromocytoma Benign | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7| DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0| | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| Adenoma | X | Adenoma, Multiple | X | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + M + M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| Pars Distalis, Leukemia Mononuclear | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M A + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Chordoma | X | Leukemia Mononuclear | | Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + M + + + M + M + + + + + + + + + + + + M +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | M + + + + + + + M + + + + + + M + M + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Seminal Vesicle | + + + + | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X | Interstitial Cell, Adenoma | X X X X X X X X X | Tunic, Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | | Mesenteric, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7| DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0| | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M M + + + + + M + + + + + + + I +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Thymus | + + + + + + M + + + M + + + + + + + + + + M + + M| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + M M M M M M M + M M + + M M + + M M + + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + M + + + + + + + +| Basal Cell Carcinoma | X | Keratoacanthoma | | Squamous Cell Carcinoma | | Trichoepithelioma | X | Lip, Squamous Cell Carcinoma | X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, | | Neurofibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | X X | Oligodendroglioma Benign | X | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + I + + + + + + + + + + A + + A + + I +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Sarcoma, Metastatic | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 _____________________________________________________________________________________________________________________ | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7| DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0| | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant, Metastatic, | | Testes | | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| | DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| | | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + M + + + + + + + + + + + M M + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + A + + +| 45 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + M + + + + + + + + + + + M + + + + + + M + + +| 43 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + M + + + + + + + M + + + + M + + + + A + + +| 40 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 34 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | Neoplastic Nodule, Multiple | X | 1 | __________________________________________________________________________|____________| Mesentery | + | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 7 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cortex, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Serosa, Mesothelioma Malignant, | | | Metastatic, Testes | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 14 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| | DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| | | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X | 15 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X | 10 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X | 2 | Bilateral, Pheochromocytoma Benign | X X X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Adenoma | X | 2 | Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + + + M + M + + + M + M| 41 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | Pars Distalis, Adenoma | X X X X X X X X X X | 25 | Pars Distalis, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + +| 4 | Chordoma | | 1 | Leukemia Mononuclear | X | 1 | Sarcoma | X| 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + M M + + I + + + + + + + + + M + + +| 42 | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 45 | Adenoma | X | 1 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Seminal Vesicle | + +| 6 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X | 8 | Interstitial Cell, Adenoma | X X X X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| | DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| | | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Tunic, Mesothelioma Malignant | X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + | 4 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | Mesenteric, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M M + M + + + + + + + + M + M M + + + M| 38 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X | 35 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | __________________________________________________________________________|____________| Thymus | I + M + + M + + + M + + + + + + M + + + + + + + +| 41 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M M M M M M M M M + + M M M M M M + M + M M| 14 | __________________________________________________________________________|____________| Skin | + + + + + + + + + M M + + + + + + + + + + + M + +| 46 | Basal Cell Carcinoma | X X | 3 | Keratoacanthoma | X X | 2 | Squamous Cell Carcinoma | X | 1 | Trichoepithelioma | | 1 | Lip, Squamous Cell Carcinoma | | 1 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 1 | Subcutaneous Tissue, | | | Neurofibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| | DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| | | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | Leukemia Mononuclear | X X | 4 | Oligodendroglioma Benign | | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + I + + + + + +| 44 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 27 | Sarcoma, Metastatic | X| 1 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 7 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 14 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 4 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 36 | Mesothelioma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 332888-332888/332888 --multipart-boundary--