TR 346 Rat Pathology Tables
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + I + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | I + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + M + + + + + + + + + + +|
Sarcoma, Metastatic, Tissue NOS | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Tissue NOS | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X |
Sarcoma, Metastatic, Bone | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | M M + + + M + + + + + I + + + + M + + + M + + M M|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | |
Sarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + I + M M + + + M + M + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + M + + + M + + + + M + +|
Adenoma | X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Bone | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | X |
Mesenteric, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + M + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Bone | X |
Mesenteric, Sarcoma, Metastatic, | |
Tissue NOS | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + M + + + + + + + + M I M +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + M + + + + + M + M + + + + + M + + M + + M + + I|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + M + + + +|
Adenoma | |
Fibroadenoma | X X X X X X|
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + M M + + + + + + + + + M + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
Periosteum, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X X X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Sarcoma, Metastatic, Tissue NOS | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 19 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 |
Leukemia Mononuclear | X X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Tissue NOS | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + M + +| 46 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Leukemia Mononuclear | X X | 6 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + M + + + + + + I + + + M + + + I + + M I| 35 |
Leukemia Mononuclear | X X X X X | 7 |
Pheochromocytoma Benign | X | 1 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + M M M + + + + + + + + M + M +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X | 26 |
Pars Distalis, Carcinoma | X X X | 6 |
Pars Distalis, Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
C-Cell, Adenoma | X X X | 5 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Adenoma | | 1 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Polyp Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mediastinal, Leukemia Mononuclear | X | 1 |
Mesenteric, Leukemia Mononuclear | X | 2 |
Mesenteric, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Leukemia Mononuclear | X X X X X X | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Bone | | 1 |
Mesenteric, Sarcoma, Metastatic, | | |
Tissue NOS | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + M M + + + + + + + + M M + + +| 39 |
Leukemia Mononuclear | X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 19 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + M + + + + + + M + + + M| 38 |
Leukemia Mononuclear | X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X | 2 |
Fibroadenoma | X X X X X | 11 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
Periosteum, Leukemia Mononuclear | X X X | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X X | 5 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X X X X X | 15 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 20 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + M A M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + M + + + + + + + A A + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Leukemia Lymphocytic | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
Schwannoma Malignant, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Leukemia Mononuclear | X X X |
Schwannoma Malignant, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Pharynx | + |
Palate, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Leukemia Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Leukemia Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | I M + + + + + + + + M + + + M + I M + M + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + M M M + + + + + + + M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X X |
Pars Distalis, Carcinoma, Metastatic,| |
Zymbal's Gland | |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + A + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + I + + M M + + + + + M + + M + +|
Adenoma | X X X|
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + M|
Leukemia Lymphocytic | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | M M + + + + + + M + + M + + M + + M + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Periosteum, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Skeletal Muscle | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X |
Meninges, Carcinoma, Metastatic, | |
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Lymphocytic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma, Metastatic, | |
Skin | X |
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Leukemia Mononuclear | X X X X X X X X X X|
Sarcoma, Metastatic, Ear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Lymphocytic | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Sarcoma | |
__________________________________________________________________________|
Eye | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Uncertain Primary Site | X |
Leukemia Lymphocytic | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Lymphocytic | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + M + + + + + + + + A + + + + + +| 43 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 25 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Schwannoma Malignant, Metastatic, | | |
Stomach | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Leukemia Mononuclear | X | 4 |
Schwannoma Malignant, Metastatic, | | |
Stomach | X | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 2 |
Palate, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Leukemia Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + I + + + + + + M +| 40 |
Leukemia Mononuclear | X X X | 6 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + M M M + + + I M + M + + M M + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X| 30 |
Pars Distalis, Carcinoma | X | 3 |
Pars Distalis, Carcinoma, Metastatic,| | |
Zymbal's Gland | X | 1 |
Pars Distalis, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + M + + + + + + + + + + + + + + + +| 43 |
Adenoma | X | 4 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X X X | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Mesenteric, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Leukemia Mononuclear | X X X X| 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + M M + + + + + + + + M + + + M| 43 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X X X X X X| 23 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M M M M + + + M + + + + + + + + + + +| 39 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 1 |
Adenoma | | 1 |
Fibroadenoma | X X X | 8 |
Fibroadenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Periosteum, Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Fibrous Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X X | 3 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
Leukemia Mononuclear | X X | 3 |
Meninges, Carcinoma, Metastatic, | | |
Zymbal's Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Leukemia Mononuclear | X X X X X X| 16 |
Sarcoma, Metastatic, Ear | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
Adenoma | | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Lymphocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + M + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + M + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + I + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
Lymphoma Malignant Histiocytic | X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + M + + M + + M M M + + + + + + + M +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | X X X|
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M M + + M M M M + + + + + + M + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Adenoma, Multiple | X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + M M + + M + + + + M + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + I + M + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + I + M + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + M M + + + + + M + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M M + + M M M M M M M M M M M M +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granular Cell Tumor Malignant | |
Leukemia Mononuclear | X X |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mediastinum, Mesothelioma Benign | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M + |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Lipoma, Moderate | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Lymphoma Malignant Histiocytic | X |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 31 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Pharynx | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + +| 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 12 |
Schwannoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + I + + + M I + + M + M + M M + + + + + + + + + +| 36 |
Leukemia Mononuclear | X X | 8 |
Pheochromocytoma Benign | X X X X | 7 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Adenoma | X X X | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + M + + + M + + + + + M + + + M M + + +| 31 |
Adenoma | X| 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 7 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 31 |
Pars Distalis, Carcinoma | X | 1 |
Pars Distalis, Leukemia Mononuclear | | 3 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X X X X | 6 |
C-Cell, Adenoma, Multiple | | 1 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + I + + M + + M + M M + + + + M + M + M + + + +| 37 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X| 19 |
Interstitial Cell, Adenoma | X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Mesenteric, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + M + + M + M + + + + M + + + +| 42 |
Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + M| 45 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 30 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + + + + M + + M M + + + + + M + +| 39 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M + M M M + + M M M M + + + +| 13 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Keratoacanthoma | X X X | 4 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granular Cell Tumor Malignant | X | 1 |
Leukemia Mononuclear | | 2 |
Oligodendroglioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Mesothelioma Benign | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 12 |
Lipoma, Moderate | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 33 |
Lymphoma Malignant Histiocytic | | 1 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M M + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A|
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M A A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + M + + + + + + + + + + + + + A A + M A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + A A + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
Mesothelioma Malignant, Metastatic, | |
Testes | |
Neoplastic Nodule, Multiple | |
__________________________________________________________________________|
Mesentery | |
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant, | |
Metastatic, Testes | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
Adenoma | X |
Adenoma, Multiple | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + M + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M A + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Chordoma | X |
Leukemia Mononuclear | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + M + M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + M + + + + + + M + M + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Mesenteric, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + M + + + + + + + I +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M + + + + + + + + + + M + + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M + M M + + M M + + M M + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Basal Cell Carcinoma | X |
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Trichoepithelioma | X |
Lip, Squamous Cell Carcinoma | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X X |
Oligodendroglioma Benign | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + + + + + + A + + A + + I +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Sarcoma, Metastatic | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant, Metastatic, | |
Testes | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + M M + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + A + + +| 45 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + M + + + + + + M + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + + M + + + + M + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 34 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
Neoplastic Nodule, Multiple | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 7 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Serosa, Mesothelioma Malignant, | | |
Metastatic, Testes | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 10 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X | 2 |
Bilateral, Pheochromocytoma Benign | X X X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Adenoma | X | 2 |
Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + M + + + M + M| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
Pars Distalis, Adenoma | X X X X X X X X X X | 25 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + +| 4 |
Chordoma | | 1 |
Leukemia Mononuclear | X | 1 |
Sarcoma | X| 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M M + + I + + + + + + + + + M + + +| 42 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 45 |
Adenoma | X | 1 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X| 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + +| 6 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X| 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X | 8 |
Interstitial Cell, Adenoma | X X X X X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Tunic, Mesothelioma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X| 1 |
Mesenteric, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M M + M + + + + + + + + M + M M + + + M| 38 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X | 35 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
__________________________________________________________________________|____________|
Thymus | I + M + + M + + + M + + + + + + M + + + + + + + +| 41 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M M M M M M M + + M M M M M M + M + M M| 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M M + + + + + + + + + + + M + +| 46 |
Basal Cell Carcinoma | X X | 3 |
Keratoacanthoma | X X | 2 |
Squamous Cell Carcinoma | X | 1 |
Trichoepithelioma | | 1 |
Lip, Squamous Cell Carcinoma | | 1 |
Sebaceous Gland, Adenoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
Subcutaneous Tissue, Lipoma | X | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05078-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X | 1 |
Leukemia Mononuclear | X X | 4 |
Oligodendroglioma Benign | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + + +| 44 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 27 |
Sarcoma, Metastatic | X| 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 14 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X| 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X | 36 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
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